Synthesis Of Aza Spirocyclic Dienones And Their Application Toward Natural Product Synthesis And Synthesis And Evaluation Of Anticancer Tetracyclic Indole Containing Compounds PDF Download
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Author | : William Laurence Montgomery |
Publisher | : |
Total Pages | : 1184 |
Release | : 2016 |
Genre | : |
ISBN | : |
Download Synthesis of Aza-spirocyclic Dienones and Their Application Toward Natural Product Synthesis and Synthesis and Evaluation of Anticancer Tetracyclic Indole Containing Compounds Book in PDF, ePub and Kindle
A novel route to access the aza-spirocyclic cross-conjugated dienone motif was developed utilizing an intramolecular phenolic C-alkylation and Suzuki coupling to form the key quaternary carbon center. A chemoselective addition of crotyl silane to the azaspirocyclic dienone motif was developed in an effort to synthesize the spirobicyclononane core of (±)-aspernomine and (±) sespenine. The structure-activity-relationship of anticancer tetracyclic indole containing compounds was developed via the synthesis and biological evaluation of 48 novel derivatives. Additionally, tool compounds containing a biotin and photoaffinity crosslinker were synthesized for use in future target identification studies.
Author | : Jie Jack Li |
Publisher | : Springer Science & Business Media |
Total Pages | : 292 |
Release | : 2013-03-14 |
Genre | : Science |
ISBN | : 3642340652 |
Download Total Synthesis of Natural Products Book in PDF, ePub and Kindle
'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author | : Paul M. Dewick |
Publisher | : John Wiley & Sons |
Total Pages | : 524 |
Release | : 2002-01-03 |
Genre | : Medical |
ISBN | : 9780471496410 |
Download Medicinal Natural Products Book in PDF, ePub and Kindle
This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Author | : Andrea Basso |
Publisher | : Frontiers Media SA |
Total Pages | : 150 |
Release | : 2019-03-22 |
Genre | : |
ISBN | : 2889457885 |
Download Diversity Oriented Synthesis Book in PDF, ePub and Kindle
Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee its shape in the next decade.
Author | : Jie Jack Li |
Publisher | : CRC Press |
Total Pages | : 222 |
Release | : 2016-10-03 |
Genre | : Medical |
ISBN | : 1498729096 |
Download Carbocation Chemistry Book in PDF, ePub and Kindle
Gives a comprehensive and up-to-date summary of carbocation chemistry. Discusses the widespread applications of carbocation chemistry, with an emphasis on organic synthesis. Contains the contributions of highly experienced authors. Provides a panoramic view of carbocation chemistry, which is part of the foundation of organic chemistry.
Author | : Gordon W. Gribble |
Publisher | : John Wiley & Sons |
Total Pages | : 704 |
Release | : 2016-08-08 |
Genre | : Science |
ISBN | : 0470512180 |
Download Indole Ring Synthesis Book in PDF, ePub and Kindle
Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
Author | : Tsutomu Ishikawa |
Publisher | : John Wiley & Sons |
Total Pages | : 336 |
Release | : 2009-01-26 |
Genre | : Science |
ISBN | : 9780470740866 |
Download Superbases for Organic Synthesis Book in PDF, ePub and Kindle
Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.
Author | : Lutz F. Tietze |
Publisher | : John Wiley & Sons |
Total Pages | : 631 |
Release | : 2006-12-13 |
Genre | : Science |
ISBN | : 3527608680 |
Download Domino Reactions in Organic Synthesis Book in PDF, ePub and Kindle
Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.
Author | : Vishnu Ji Ram |
Publisher | : Elsevier |
Total Pages | : 500 |
Release | : 2019-06-05 |
Genre | : Science |
ISBN | : 0081011911 |
Download The Chemistry of Heterocycles Book in PDF, ePub and Kindle
Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described. Gives in-depth, clear information about various systems of nomenclature along with widely acceptable IUPAC system for naming various classes of heterocycles Provides complete information about natural occurrences, synthesis, chemical reactivity, pharmacological importance of heterocycles and their application in material science Highly relevant for graduate students and researchers, providing updated information about various isolated and fused N,O and,S containing heterocycles
Author | : Mohammad Hossein Keshavarz |
Publisher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 143 |
Release | : 2020-05-05 |
Genre | : Technology & Engineering |
ISBN | : 311067775X |
Download Energetic Compounds Book in PDF, ePub and Kindle
This book discusses methods for the assessment of energetic compounds through heat of detonation, detonation pressure, velocity and temperature, Gurney energy and power. The authors focus on the detonation pressure and detonation velocity of non-ideal aluminized energetic compounds. This 2nd Edition includes an updated and improved presentation of simple, reliable methods for the design, synthesis and development of novel energetic compounds.