Synthesis Characterization And Surface Functionalization Of Polyisobutylene Based Biomaterials PDF Download
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| Author | : Elizabeth Anne Orlowski |
| Publisher | : |
| Total Pages | : 223 |
| Release | : 2009 |
| Genre | : Biomedical materials |
| ISBN | : |
Download Synthesis, Characterization, and Surface Functionalization of Polyisobutylene Based Biomaterials Book in PDF, ePub and Kindle
"Synthesis of the inimer (initiator-monomer) 4-(1,2-oxirane-isopropyl)styrene (EPOIM) and copolymerization of this inimer with isobutylene (IB) to form arborescent polyisobutylene (arb_PIB) was carried out using TiCl4 coinitiator. The effect of reaction conditions was investigated. Size exclusion chromatography (SEC) was used to show incorporation of EPOIM across the molecular weight distribution. The average number of branches was measured by selective link destruction. Polymer architecture analysis was carried out using branching parameters based on the radii of gyration (Rg) and hydrodynamic radii (Rh) determined by multidetector SEC. In situ FTIR was utilized to monitor the polymerization of EPOIM. Block copolymers were synthesized by the blocking of arb_PIB with p-methylstyrene to form novel 4th generation SIBS materials, arb_poly[isobutylene(OH)-b-(isobutylene-co-pmethylstyrene] [arb_IB(OH)-MS]. Proof of the presence of hydroxyl groups in the polymer was obtained using 1H-NMR spectroscopy and by silylation with chlorotrimethylsilane. The reinforcement and surface functionalization of thermoplastic elastomers (TPEs) for soft tissue replacement was investigated. The materials investigated were soft TPE based PIBs, with surfaces more hydrophilic than poly(styrene-b-isobutylene-b-styrene) (SIBS) and silicone rubber. The material reinforced with carbon black (CB) [arb_IB(OH)-MS_CB] had an interpenetrating network structure, in which the Tg of the dispersed phase increased to 126 oC, making the material steam-sterilizable. It also had the lowest water contact angle at 82o, and superior mechanical properties in comparison with silicone rubber. After 180 days implantation into rabbits arb_IB(OH)-MS_CB displayed the thinnest capsule around the implant in comparison to arb_IB(OH)-MS and silicone. A new method of surface functionalization to increase the hydrophilicity of arb_IB(OH)-MS was developed. Using a low molecular weight thymine-functionalized polyisobutylene (PIB-T), a layer of PIB-T was spin coated on top of a layer of arb_IB(OH)-MS. This resulted in the "gluing" of the low molecular weight PIB-T onto the surface of the arb_IB(OH)-MS, and showed a 15° decrease in contact angle indicating an increase in hydrophilicity. Evidence of nitrogen and oxygen near the surface of the polymers containing thymine was obtained by XPS. These low molecular weight PIB-Ts will be electrosprayed onto the surface of the arb_IB(OH)-MS; the products are expected to show properties similar to those obtained by spin coating. Surfaces with PIB-T will allow for hydrogen bonding of various proteins to allow the surface to be modified."--Abstract.
| Author | : Alejandra Alvarez Albarran |
| Publisher | : |
| Total Pages | : 262 |
| Release | : 2014 |
| Genre | : Biomedical materials |
| ISBN | : |
Download Modular Surface Functionalization of Polyisobutylene-based Biomaterials Book in PDF, ePub and Kindle
Polyisobutylene (PIB) has a unique combination of properties including chemical/oxidative resistance, low Tg (~70 °C) and hydrophobicity.1 PIB-based materials have also been found to have excellent biocompatibility and biostability: a PIB-based triblock copolymer thermoplastic elastomer (TPE) [poly(styrene-b-isobutylene-b-styrene)] (SIBS) is FDA-approved as a drug eluting coating for coronary stents.2 A new generation of PIB-based TPEs, with an arborescent or tree-like core (arbPIB) and plastic phases composed of blocks of polystyrene or poly(p-methyl styrene) (MS) has been developed in Professor Puskas group. These materials display unique TPE properties to make them very attractive for biomedical applications.3 The biocompatibility of these novel block copolymers has already been demonstrated in vitro and in vivo in rabbits.4 The Puskas group proposed to modify the surface properties of PIB-based TPEs using a modular approach. Using this approach it is possible to modify the surface chemistry and topology independently. The surface chemistry can be modified by "gluing" low molecular weight functionalized PIBs (PIB-X) to the surface of the TPEs. This "modular" approach will give unprecedented control over surface chemistry and topology and will contribute to new fundamental understanding of the effects of surface properties on the biocompatibility of polymeric materials. In this work PIB with a primary hydroxy head group (HO-PIB) was made in situ by living carbocationic polymerization using propylene oxide as initiator and titanium tetrachloride (TiCl4) as coinitiator. PIB functionalized with non-fouling moieties (PIB-X) was then synthesized from HO-PIB using Candida antarctica Lipase B (CALB) as enzymatic catalyst and spin coated onto the surface of the TPE. Protein adsorption studies using Surface Plasmon Resonance (SPR) demonstrated decreased fibrinogen (Fg) adsorption to the modified surface. XPS analyses provided clear evidence of the effectiveness of the modular approach in modifying the surface chemistry of the TPE revealing that the polar groups of PIB-X migrated to the surface of the film. This modular approach is much simpler than attaching functional groups covalently to surfaces; therefore it holds great promise in practical applications to improve the tissue-implant interaction.
| Author | : Maria Cristina Tanzi |
| Publisher | : Woodhead Publishing |
| Total Pages | : 503 |
| Release | : 2017-06-20 |
| Genre | : Technology & Engineering |
| ISBN | : 0081007434 |
Download Characterization of Polymeric Biomaterials Book in PDF, ePub and Kindle
Characterization of Polymeric Biomaterials presents a comprehensive introduction on the topic before discussing the morphology and surface characterization of biomedical polymers. The structural, mechanical, and biological characterization is described in detail, followed by invaluable case studies of polymer biomaterial implants. With comprehensive coverage of both theoretical and experimental information, this title will provide scientists with an essential guide on the topic of these materials which are regularly used for clinical applications, such as implants and drug delivery devices. However, a range of novel polymers and the development and modification of existing medical polymers means that there is an ongoing need to satisfy particular design requirements. This book explains the critical and fundamentals methods to characterize polymer materials for biomedical applications. Presents a self-contained reference on the characterization of polymeric biomaterials Provides comprehensive information on how to characterize biomedical polymers in order to improve design and synthesis Includes useful case studies that demonstrate the characterization of biomaterial implants
| Author | : Buddy D. Ratner |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 200 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 1489919538 |
Download Surface Modification of Polymeric Biomaterials Book in PDF, ePub and Kindle
Applications of synthetic materials in medicine date back over 4000 year2. The Egyptians used linen as sutures. In the Roman Empire, gold was used in dentistry. Perhaps even earlier, ivory and bone may have been used in the body by practitioners of the healing arts. The historical origins of modem biomaterials science are also hard to precisely trace, but many of the ideas that define biomaterials as we know them today evolved in the late 1950s and early 1960s. Surface modification technology has played a prominent role in biomaterials science, and has paralleled the evolution of the modem field. In a symposium organized by the Artifical Heart Program of the NIH National Heart Institute and the Artificial Kidney program of the NIH National Institute of Arthritis and Metabolic Diseases, held in Atlantic City, New Jersey, in 1968, there were already a number of presentations on surface modification. Surface characterization at that time included scanning electron microscopy, ellipsometry, contact angle methods, and infrared internal reflection methods.
| Author | : Jianxun Ding |
| Publisher | : Frontiers Media SA |
| Total Pages | : 457 |
| Release | : 2021-08-18 |
| Genre | : Science |
| ISBN | : 2889711935 |
Download Synthesis, Functionalization, and Clinical Translation of Pharmaceutical Biomaterials Book in PDF, ePub and Kindle
| Author | : Andreas Lendlein |
| Publisher | : John Wiley & Sons |
| Total Pages | : 65 |
| Release | : 2011-09-19 |
| Genre | : Technology & Engineering |
| ISBN | : 3527635823 |
Download Handbook of Biodegradable Polymers Book in PDF, ePub and Kindle
A comprehensive overview of biodegradable polymers, covering everything from synthesis, characterization, and degradation mechanisms while also introducing useful applications, such as drug delivery systems and biomaterial-based regenerative therapies. An introductory section deals with such fundamentals as basic chemical reactions during degradation, the complexity of biological environments and experimental methods for monitoring degradation processes. The result is a reliable reference source for those wanting to learn more about this important class of polymer materials, as well as scientists in the field seeking a deeper insight.
| Author | : Luigia Sabbatini |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 403 |
| Release | : 2022-01-19 |
| Genre | : Technology & Engineering |
| ISBN | : 311070109X |
Download Polymer Surface Characterization Book in PDF, ePub and Kindle
This fully updated edition provides a broad approach to the surface analysis of polymers being of high technological interest. Modern analytical techniques, potential applications and recent advances in instrumental apparatus are discussed. The self-consistent chapters are devoted to techniques from photoelectron spectroscopy to electron microscopies and wettability.
| Author | : Stuart L. Cooper |
| Publisher | : VSP |
| Total Pages | : 1174 |
| Release | : 1995-03 |
| Genre | : Science |
| ISBN | : 9789067641807 |
Download Polymer Biomaterials in Solution, As Interfaces And As Solids Book in PDF, ePub and Kindle
The articles collected in this publication have previously been published in eight special issues of the Journal of Biomaterials Science, Polymer Edition, in honour of Dr. Allan S. Hoffman, who is known as a pioneer, a leader and a mentor in the field of biomaterials. The papers from renowned scientists from all parts of the world, representing the state-of-the-art in polymeric biomaterials today, have been rearranged into a logical order of sections, each having a distinct focus. The topics covered are: Surface Modification, Characterization and Properties; Protein Adsorption; Blood Interactions; Cell Interactions; Immobilized Cell Receptor Ligands and Immobilized Cells; Immobilized Biomolecules and Synthetic Derivatives of Biomolecules; New Polymers and Applications; Biodegradable Polymers and Drug Delivery; Water-Soluble Biomolecules, Sunthetic Polymers, and their Conjugates; Hydrogels.
| Author | : Hriday Bera |
| Publisher | : Woodhead Publishing |
| Total Pages | : 789 |
| Release | : 2021-07-28 |
| Genre | : Medical |
| ISBN | : 0128214570 |
Download Tailor-Made and Functionalized Biopolymer Systems Book in PDF, ePub and Kindle
Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists. Provides a concise overview of tailor-made and functionalized biopolymer systems for biomedical applications Covers a range of modified biopolymers, biopolymeric composites and biopolymer-based systems in drug delivery, development of artificial organs, diagnostic applications, and more Describes characterization, synthesis and functionalization of biopolymers and biopolymers systems
| Author | : Matthias Häußler |
| Publisher | : Springer |
| Total Pages | : 244 |
| Release | : 2007-06-02 |
| Genre | : Technology & Engineering |
| ISBN | : 3540715096 |
Download Functional Materials and Biomaterials Book in PDF, ePub and Kindle
This book has the highest impact factor of all publications ranked by ISI within polymer science. It contains short and concise reports on physics and chemistry of polymers, each written by the world renowned experts. It remains valid and useful after 5 or 10 years. The electronic version is available free of charge for standing order customers at: springer.com/series/12/.
