Synthesis And Characterization Of Drug Carrier Based On Polysaccharides PDF Download
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Author | : Prof. (Dr.) Nirmal K. Patel |
Publisher | : GRIN Verlag |
Total Pages | : 255 |
Release | : 2023-01-09 |
Genre | : Science |
ISBN | : 3346788253 |
Download Synthesis and characterization of drug carrier based on polysaccharides Book in PDF, ePub and Kindle
Doctoral Thesis / Dissertation from the year 2022 in the subject Chemistry - Other, , language: English, abstract: The title of this thesis “Synthesis and Characterization of Drug Carrier Based on Polysaccharides” clearly reflects the objective, which is an approach towards preparation of excipients, defined as ‘the substance used as a medium for giving a medicament’, that is to say with simply the functions of an inert support of the active principle or principles. Okra gum, obtained from the fruits of Hibiscus esculents, is a polysaccharide consisting of D-galactose, L-rhamnose and L-galacturonic acid. It is used as a binder. In studies okra gum has been evaluated as a binder in paracetamol tablet formulations. These formulations containing okra gum as a binder showed a faster onset and higher amount of plastic deformation than those containing gelatin. The crushing strength and disintegration times of the tablets increased with higher binder concentration, while their friability decreased. Although gelatin produced four tablets with higher crushing strength, okra gum produced tablets with longer disintegration times than those containing gelatin. It was finally concluded from the results that okra gum may be a useful hydrophilic matrixing agent in sustained drug delivery system. Various strategies were developed in order to overcome these issues, offering the opportunity to tailor the physical and chemical properties of okra gum thus yielding materials that may find a wide range of applications. Extraction and purification of okra gum was carried out from okra pods. Followed by carboxymethylated and phosphorylation of extracted okra gum, which was carried out along with optimization of reaction parameter of the primary derivatives that is carboxymethylated okra gum and hydroxyl propyl okra phosphate, followed by drug carriers preparation. By the second modification carboxymethylated okra gum and hydroxyl propyl okra phosphate were carried out by cross linking acrylic acid, N, N-methylene acryl amide, hydroxyethyl methacrylate (HEMA) respectively synthesized cross-linked polymer were further investigated as drug carriers by formulating as tablet for sustained drug release. The drug release of different formulations were measured in relation to time and also compared with the standard drugs. Further mathematical modeling was implemented to know the order of release behavior of formulated tables.
Author | : Tapan Kumar Giri |
Publisher | : CRC Press |
Total Pages | : 371 |
Release | : 2018-09-03 |
Genre | : Medical |
ISBN | : 0429830661 |
Download Polysaccharide based Nano-Biocarrier in Drug Delivery Book in PDF, ePub and Kindle
This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.
Author | : Amit Kumar Nayak |
Publisher | : Academic Press |
Total Pages | : 416 |
Release | : 2022-09-02 |
Genre | : Business & Economics |
ISBN | : 012821287X |
Download Tailor-Made Polysaccharides in Drug Delivery Book in PDF, ePub and Kindle
Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications.The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery. Provides methodologies for the design, development and selection of tailor-made, natural polysaccharides in drug delivery for particular therapeutic applications Includes illustrations that demonstrate the mechanism of biological interaction of tailor-made polysaccharides Discusses the regulatory aspects and demonstrates the clinical efficacy of tailor-made polysaccharides
Author | : Shakeel Ahmed |
Publisher | : Elsevier |
Total Pages | : 675 |
Release | : 2023-09-05 |
Genre | : Technology & Engineering |
ISBN | : 0323993427 |
Download Polysaccharides-Based Hydrogels Book in PDF, ePub and Kindle
Polysaccharide-Based Hydrogels: Synthesis, Characterization and Applications looks at the synthesis, characterization and application of polysaccharide-based materials in a broad array of fields. The book discusses the role of polysaccharides in the preparation of hydrogels, the use of hydrogel-based green materials, and their applications in biomedical applications, drug delivery, water purification techniques, food industries, agricultural fields, and pharmaceuticals applications. Written by leading experts in this field, this book will be a valuable reference for scientists, academicians, researchers, technologists, consultants and policymakers. Explains origin, extraction, processing, structural analysis and applications of polysaccharides-based hydrogels Includes chapters that specifically focus on a particular hydrogel Provides specific applications of polysaccharide hydrogels
Author | : Sabyasachi Maiti |
Publisher | : Woodhead Publishing |
Total Pages | : 802 |
Release | : 2019-06-14 |
Genre | : Medical |
ISBN | : 0081025548 |
Download Polysaccharide Carriers for Drug Delivery Book in PDF, ePub and Kindle
Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented is scattered, therefore becoming difficult for readers and researchers to digest in a concise manner. This gathering of information will help readers easily comprehend the subject matter. Focuses on biopolysaccharide-based, distinct approaches for drug delivery applications Illustrates new concepts and highlights future scope for clinical development Provides comprehensive, up-to-date information on different aspects of drug delivery technology
Author | : Jayachandran Venkatesan |
Publisher | : Elsevier |
Total Pages | : 410 |
Release | : 2017-05-30 |
Genre | : Science |
ISBN | : 0128098171 |
Download Seaweed Polysaccharides Book in PDF, ePub and Kindle
Seaweed Polysaccharides: Isolation, Biological, and Biomedical Applications examines the isolation and characterization of algal biopolymers, including a range of new biological and biomedical applications. In recent years, significant developments have been made in algae-based polymers (commonly called polysaccharides), and in biomedical applications such as drug delivery, wound dressings, and tissue engineering. Demand for algae-based polymers is increasing and represent a potential—very inexpensive—resource for these applications. The structure and chemical modification of algal polymers are covered, as well as the biological properties of these materials – including antithrombic, anti-inflammatory, anticoagulant, and antiviral aspects. Toxicity of algal biopolymers is also covered. Finally, the book introduces and explains real world applications of algal-based biopolymers in biomedical applications, including tissue engineering, drug delivery, and biosensors. This is the first book to cover the extraction techniques, biomedical applications, and the economic perspective of seaweed polysaccharides. It is an essential text for researchers and industry professionals looking to work with this renewable resource. Provides comprehensive coverage of the research currently taking place in biomedical applications of algae biopolymers Includes practical guidance on the isolation, extraction, and characterization of polysaccharides from sustainable marine sources Covers the extraction techniques, biomedical applications, and economic outlook of seaweed polysaccharides
Author | : Jayachandran Venkatesan |
Publisher | : Elsevier |
Total Pages | : 692 |
Release | : 2022-01-11 |
Genre | : Technology & Engineering |
ISBN | : 0128223561 |
Download Polysaccharide Nanoparticles Book in PDF, ePub and Kindle
Polysaccharide Nanoparticles: Preparation and Biomedical Applications provides detailed information on polysaccharides nanoparticles in terms of their synthesis and applications. Naturally occurring polysaccharides are widely used as food materials, particularly in Asia. Different kinds of polysaccharide materials are available from nature with various resources such as crustaceans and algae. The exploration and exploitation of polysaccharides nanoparticles from natural resource is at the heart of this book, which also explores the synthesis, preparation and applications of polysaccharides nanoparticles for tissue engineering and food applications. This is an important reference for materials scientists and bioengineers who are looking to gain a greater understanding on how polysaccharides nanoparticles are being used for a variety of biomedical applications. Explains the major synthesis and preparation methods of polysaccharide-based nanoparticles Demonstrates how polysaccharides nanoparticles are being used for a range of biomedical applications, including tissue engineering, drug delivery and biosensors Assesses the major challenges and risks of using polysaccharides nanoparticles safely and effectively
Author | : R. H. Marchessault |
Publisher | : |
Total Pages | : 392 |
Release | : 2006 |
Genre | : Language Arts & Disciplines |
ISBN | : |
Download Polysaccharides for Drug Delivery and Pharmaceutical Applications Book in PDF, ePub and Kindle
Cellulose and starch are dry binders for tablets. They are essential for drug formulation and for slow-release to maintain drug concentration in the blood. Unusual excipient uses are described such as protein separation and purification, gene delivery and iron content in human physiology.
Author | : Inamuddin |
Publisher | : John Wiley & Sons |
Total Pages | : 786 |
Release | : 2021-06-29 |
Genre | : Technology & Engineering |
ISBN | : 111971138X |
Download Polysaccharides Book in PDF, ePub and Kindle
This book provides the whole spectrum of polysaccharides from basic concepts to commercial market applications. Chapters cover various types of sources, classification, properties, characterization, processing, rheology and fabrication of polysaccharide-based materials and their composites and gels. The applications of polysaccharides include in cosmetics, food science, drug delivery, biomedicine, biofuel production, marine, packaging, chromatography and environmental remediation. It also reviews the fabrication of inorganic and carbon nanomaterials from polysaccharides. The book incorporates industrial applications and will fill the gap between the exploration works in the laboratory and viable applications in related ventures.
Author | : Hans F. Linskens |
Publisher | : Springer Science & Business Media |
Total Pages | : 402 |
Release | : 2013-03-09 |
Genre | : Science |
ISBN | : 3662027836 |
Download Plant Toxin Analysis Book in PDF, ePub and Kindle
Chemical defence by means of toxins poisonous to other organisms, be they animals or plants, is widespread amongst the plant kingdom - including microorganisms as well. This book embraces the analysis of a wide range of plant toxins and this fills a gap in the plant pathology and ecological biochemistry fields. The topics covered include toxic extracellular enzymes, host selective toxins, elicitors, phototoxins, aflatoxins, mycotoxins, and ecotoxic substance tests by pollen germination and growth. The analytical procedures, which are used to evaluate the toxins, are covered in such a way that the reader is able to carry them out mostly solely by following the detailed descriptions.