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Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions

Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions
Author: Ang Yan Shan
Publisher: Springer
Total Pages: 188
Release: 2018-09-21
Genre: Technology & Engineering
ISBN: 9811321884

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This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules – a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally – which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.


DNA Computing and Molecular Programming

DNA Computing and Molecular Programming
Author: Robert Brijder
Publisher: Springer
Total Pages: 278
Release: 2017-08-22
Genre: Computers
ISBN: 3319667998

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This book constitutes the refereed proceedings of the 23th International Conference on DNA Computing and Molecular Programming, DNA 23, held Austin, TX, USA, in September 2017. The 16 full papers presented were carefully selected from 23 submissions. Research in DNA computing aims to draw together mathematics, computerscience, physics, chemistry, biology, and nanotechnology to address the analysis, design, and synthesis of information-based molecular systems. The papers address all areas related to biomolecular computing such as: algorithms and models for computation with biomolecular systems; computational processes in vitro and in vivo; molecular motors and molecular robotics; studies of fault-tolerance and error correction; software tools for analysis, simulation, and design; synthetic biology and in vitro evolution; applications in engineering, physics, chemistry, biology, and medicine.


Structural DNA Nanotechnology

Structural DNA Nanotechnology
Author: Nadrian C. Seeman
Publisher: Cambridge University Press
Total Pages: 269
Release: 2015
Genre: Computers
ISBN: 0521764483

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Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.


Design of DNA Strand Displacement Based Circuits

Design of DNA Strand Displacement Based Circuits
Author: Aby Konampurath George
Publisher:
Total Pages: 145
Release: 2017
Genre: Nanoscience
ISBN:

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The reduction in the number of unique strands will consequently reduce the leakage reactions, circuit complexity, and cost associated with the DNA circuits. The real world biological inputs are analog in nature. If we can use those analog signals directly in the circuits, it can considerably reduce the resources required. Even though analog circuits are highly prone to noise, they are a perfect candidate for performing computations in the resource-limited environments, such as inside the cell. In the analog domain, we are developing a novel fuzzy inference engine using analog circuits such as the minimum gate, maximum gate, and fan-out gates. All the circuits discussed in this research were designed and tested in the Visual DSD software. The biological inputs are inherently fuzzy in nature, hence a fuzzy based system can play a vital role in future decision-making circuits. We hope that our research will be the first step towards realizing these larger goals. The ultimate aim of our research is to develop novel approaches for the design of circuits which can be used with the future biological devices to tackle many medical problems such as genetic disorders.


DNA in Supramolecular Chemistry and Nanotechnology

DNA in Supramolecular Chemistry and Nanotechnology
Author: Eugen Stulz
Publisher: John Wiley & Sons
Total Pages: 538
Release: 2015-07-14
Genre: Technology & Engineering
ISBN: 111869693X

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This book covers the emerging topic of DNA nanotechnology and DNA supramolecular chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has become a very versatile building block in materials chemistry, supramolecular chemistry and bio-nanotechnology. Many novel structures have been realized in the past decade, which are now being used to create molecular machines, drug delivery systems, diagnosis platforms or potential electronic devices. The book combines many aspects of DNA nanotechnology, including formation of functional structures based on covalent and non-covalent systems, DNA origami, DNA based switches, DNA machines, and alternative structures and templates. This broad coverage is very appealing since it combines both the synthesis of modified DNA as well as designer concepts to successfully plan and make DNA nanostructures. Contributing authors have provided first a general introduction for the non-specialist reader, followed by a more in-depth analysis and presentation of their topic. In this way the book is attractive and useful for both the non-specialist who would like to have an overview of the topic, as well as the specialist reader who requires more information and inspiration to foster their own research.


2020 59th Annual Conference of the Society of Instrument and Control Engineers of Japan (SICE)

2020 59th Annual Conference of the Society of Instrument and Control Engineers of Japan (SICE)
Author: IEEE Staff
Publisher:
Total Pages:
Release: 2020-09-23
Genre:
ISBN: 9781728110905

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The scope includes research in the area of Measurement, Control Theory and Applications, Mechatronics, Industrial Automation, Transportation, Biological and Medical Systems, Artificial Intelligence, Cyber Physical Systems, Smart Grids, Educational and Social Contributions


21st Century Nanoscience – A Handbook

21st Century Nanoscience – A Handbook
Author: Klaus D. Sattler
Publisher: CRC Press
Total Pages: 345
Release: 2020-04-22
Genre: Science
ISBN: 1000702537

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This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This eighth volume in a ten-volume set covers nanopharmaceuticals, nanomedicine, and food nanoscience. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in the field. Emphasises presentation and real results and applications. This handbook distinguishes itself from other works by its breadth of coverage, readability and timely topics. The intended readership is very broad, from students and instructors to engineers, physicists, chemists, biologists, biomedical researchers, industry professionals, governmental scientists, and others whose work is impacted by nanotechnology. It will be an indispensable resource in academic, government, and industry libraries worldwide. The fields impacted by nanophysics extend from materials science and engineering to biotechnology, biomedical engineering, medicine, electrical engineering, pharmaceutical science, computer technology, aerospace engineering, mechanical engineering, food science, and beyond.


Theory and Practice of Natural Computing

Theory and Practice of Natural Computing
Author: Carlos Martín-Vide
Publisher: Springer
Total Pages: 319
Release: 2017-12-12
Genre: Computers
ISBN: 3319710699

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This book constitutes the refereed proceedings of the 6th International Conference,on Theory and Practice of Natural Computing, TPNC 2017, held in Prague, Czech Republic, December 2017. The 22 full papers presented in this book, together with one invited talk, werecarefully reviewed and selected from 39 submissions. The papers are organized around the following topical sections: applications of natural computing; evolutionary computation; fuzzy logic; Molecular computation; neural networks; quantum computing.