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Author | : Committee on the Assessment of Future Scientific Needs for Variola Virus |
Publisher | : National Academies Press |
Total Pages | : 126 |
Release | : 1999-05-14 |
Genre | : Medical |
ISBN | : 030959698X |
Download Assessment of Future Scientific Needs for Live Variola Virus Book in PDF, ePub and Kindle
In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.
Author | : Mervyn Henry Gordon |
Publisher | : |
Total Pages | : 158 |
Release | : 1925 |
Genre | : Medicine |
ISBN | : |
Download Studies of the Viruses of Vaccinia and Variola Book in PDF, ePub and Kindle
Author | : Stuart N. Isaacs |
Publisher | : Springer Science & Business Media |
Total Pages | : 402 |
Release | : 2008-02-03 |
Genre | : Science |
ISBN | : 1592597890 |
Download Vaccinia Virus and Poxvirology Book in PDF, ePub and Kindle
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Author | : Andrew Mercer |
Publisher | : Springer Science & Business Media |
Total Pages | : 447 |
Release | : 2007-02-15 |
Genre | : Medical |
ISBN | : 3764375574 |
Download Poxviruses Book in PDF, ePub and Kindle
This monograph provides a comprehensive review of the poxvirus family with a particular emphasis on current developments. It includes the latest insights into poxviral molecular biology, diagnosis, therapy, vaccine development and the beneficial exploitation of these viruses in biomedical research. Each chapter is written by a leader in the field, and the book includes historical perspectives and summaries of recent advances in the field.
Author | : Centers for Disease Control and Prevention CDC |
Publisher | : Oxford University Press |
Total Pages | : 705 |
Release | : 2017-04-17 |
Genre | : Medical |
ISBN | : 0190628634 |
Download CDC Yellow Book 2018: Health Information for International Travel Book in PDF, ePub and Kindle
THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 126 |
Release | : 1999-05-30 |
Genre | : Medical |
ISBN | : 0309064414 |
Download Assessment of Future Scientific Needs for Live Variola Virus Book in PDF, ePub and Kindle
In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 1925 |
Genre | : |
ISBN | : |
Download Studies of the Viruses of Vaccinia and Variola Book in PDF, ePub and Kindle
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 170 |
Release | : 2009-11-14 |
Genre | : Medical |
ISBN | : 0309136903 |
Download Live Variola Virus Book in PDF, ePub and Kindle
Smallpox was a devastating disease that decimated human populations for centuries, and its eradication in 1980 was a monumental achievement for the global health community. Since then the remaining known strains of its causative agent, variola virus, have been contained in two World Health Organization (WHO)-approved repositories. In 1999, the World Health Assembly (WHA) debated the issue of destroying these remaining strains. Arguments were presented on the need to retain the live virus for use in additional important research, and the decision to destroy the virus was deferred until this research could be completed. In that same year, the Institute of Medicine (IOM) convened a consensus committee to explore scientific needs for the live virus. In the ten years since the first IOM report, the scientific, political, and regulatory environments have changed. In this new climate, the IOM was once again tasked to consider scientific needs for live variola virus. The committee evaluated the scientific need for live variola virus in four areas: development of therapeutics, development of vaccines, genomic analysis, and discovery research.
Author | : Universität München. Institut für Infektions- und Tropenmedizin |
Publisher | : |
Total Pages | : 48 |
Release | : 1963* |
Genre | : |
ISBN | : |
Download Experimental Studies Concerning Transformation of the Variola Virus Into the Vaccinia Virus Book in PDF, ePub and Kindle
Author | : World Health Organization |
Publisher | : World Health Organization |
Total Pages | : 74 |
Release | : 2023-09-12 |
Genre | : Medical |
ISBN | : 924007631X |
Download WHO Advisory Committee on Variola Virus Research: report of the twenty-fourth meeting, Geneva, 29–30 November 2022 Book in PDF, ePub and Kindle