Studies Of Some Platinum Ii Complexes By Nmr PDF Download
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Author | : Joyce Margaret Edward |
Publisher | : |
Total Pages | : |
Release | : 1976 |
Genre | : Complex compounds |
ISBN | : |
Download Studies of Some Platinum II Complexes by N.M.R. Book in PDF, ePub and Kindle
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author | : Joyce Margaret Edward |
Publisher | : |
Total Pages | : 0 |
Release | : 1976 |
Genre | : Complex compounds |
ISBN | : |
Download Studies of Some Platinum II Complexes by N.M.R. Book in PDF, ePub and Kindle
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author | : Patricia Aileen Cronin |
Publisher | : |
Total Pages | : 450 |
Release | : 1966 |
Genre | : Nuclear magnetic resonance |
ISBN | : |
Download NMR and Kinetic Studies of Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : Emi Miyoshi |
Publisher | : |
Total Pages | : |
Release | : 2008 |
Genre | : DNA-ligand interactions |
ISBN | : |
Download Platinum(II) Complexes Book in PDF, ePub and Kindle
Author | : Stephen B. Howell |
Publisher | : Springer Science & Business Media |
Total Pages | : 563 |
Release | : 1991 |
Genre | : Medical |
ISBN | : 030644027X |
Download Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Book in PDF, ePub and Kindle
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Author | : Catherine T. Hunt |
Publisher | : |
Total Pages | : 380 |
Release | : 1981 |
Genre | : Nuclear magnetic resonance spectroscopy |
ISBN | : |
Download Proton and Phosphorus-31 NMR Studies of Tertiary Phosphine Complexes of Palladium and Platinum Book in PDF, ePub and Kindle
Author | : Lori L. Bennett Slavin |
Publisher | : |
Total Pages | : 542 |
Release | : 1992 |
Genre | : Nuclear magnetic resonance spectroscopy |
ISBN | : |
Download Multinuclear NMR Studies of Platinum (II) Nucleotides Book in PDF, ePub and Kindle
Author | : Stephen Frederick Ralph |
Publisher | : |
Total Pages | : 632 |
Release | : 1987 |
Genre | : Platinum compounds |
ISBN | : |
Download 15N and 195Pt NMR Studies of Platinum Ammine Complexes Book in PDF, ePub and Kindle
Author | : Henry Alexander Raethel |
Publisher | : |
Total Pages | : 380 |
Release | : 1969 |
Genre | : Complex compounds |
ISBN | : |
Download Synthetic and Kinetic Studies of Some Platinum (II) Complexes Book in PDF, ePub and Kindle
Author | : G A Webb |
Publisher | : Royal Society of Chemistry |
Total Pages | : 378 |
Release | : 2007-10-31 |
Genre | : Science |
ISBN | : 1847553680 |
Download Nuclear Magnetic Resonance Book in PDF, ePub and Kindle
As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.