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Structure-based Study Of Viral Replication (With Cd-rom)

Structure-based Study Of Viral Replication (With Cd-rom)
Author: R Holland Cheng
Publisher: World Scientific
Total Pages: 663
Release: 2008-01-11
Genre: Science
ISBN: 9814476439
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This book addresses the innovative themes in characterizing the cellular membrane platforms and intracellular networking, as well as the architectural aspects of cell compartments mediated by the entry and replication cycles of viruses. The instrumentation of modern molecular and cellular biology provides a potent array of wave packets to image, detect and manipulate major dynamics of macromolecular and subviral assemblies as in the host cellular context.The book includes case studies presented with highly coherent and structured illuminations, including microscopy, spectroscopy and scanning probes. The compilation and integration of the methodology provides time-resolved observations on the reactivity of structures from near-atomic resolution to various molecular or cellular levels of descriptors. The book provides a broad introduction to the various fascinating virus systems and may be used as an advanced textbook by graduate students in biomedicine. It provides adequate background material to explore further the research problems of epidemics in the 21st century.

SARS, MERS and other Viral Lung Infections

SARS, MERS and other Viral Lung Infections
Author: David S. Hui
Publisher: European Respiratory Society
Total Pages: 148
Release: 2016-06-01
Genre: Medical
ISBN: 1849840709
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Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.

Structure-based Study of Viral Replication

Structure-based Study of Viral Replication
Author: R. Holland Cheng
Publisher: World Scientific
Total Pages: 663
Release: 2008
Genre: Science
ISBN: 9812790853
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Ch. 1. Human rhinovirus cell entry and uncoating / Renate Fuchs and Dieter Blaas -- ch. 2. Role of lipid microdomains in influenza virus multiplication / Makoto Takeda -- ch. 3. Functions of integrin alpha2beta1, a collagen receptor, in the internalization of echovirus 1 / Varpu Marjomäki [und weitere] -- ch. 4. Entry mechanism of murine and SARS coronaviruses - similarity and dissimilarity / Fumihiro Taguchi -- ch. 5. Hepatitis viruses, signaling events, and modulation of the innate host response / Syed Mohammad Moin, Anindita Kar-Roy and Shahid Jameel -- ch. 6. Virus-cell interaction of HCV / Hideki Tani [und weitere] -- ch. 7. RNA replication of hepatitis C virus / Hideki Aizaki and Tetsuro Suzuki -- ch. 8. Structure and dynamics in viral RNA packaging / Thorsten Dieckmann and Marta Zumwalt -- ch. 9. Rational design of viral protein structures with predetermined immunological properties / James Lara and Yury Khudyakov -- ch. 10. Bioinformatics resources for the study of viruses at the Virginia Bioinformatics Institute / Anjan Purkayastha [und weitere] -- ch. 11. Virus architecture probed by atomic force microscopy / A.J. Malkin [und weitere] -- ch. 12. Filovirus assembly and budding / Takeshi Noda and Yoshihiro Kawaoka -- ch. 13. Challenges in designing HIV Env immunogens for developing a vaccine / Indresh K. Srivastava and R. Holland Cheng -- ch. 14. Insights into the Caliciviridae family / Grant Hansman -- ch. 15. Mathematical approaches for stoichiometric quantification in studies of viral assembly and DNA packaging / Peixuan Guo, Jeremy Hall and Tae Jin Lee -- ch. 16. Virus-like particles of fish nodavirus / Chan-Shing Lin -- ch. 17. The assembly of the double-layered capsids of phytoreoviruses / Toshihiro Omura [und weitere] -- ch. 18. Structure and assembly of human herpesviruses: new insights from cryo-electron microscopy and tomography / Z. Hong Zhou and Pierrette Lo -- ch. 19. Human papillomavirus type 16 capsid proteins: immunogenicity and possible use as prophylactic vaccine antigens / Tadahito Kanda, Kei Kawana and Hiroyuki Yoshikawa -- ch. 20. Chimeric recombinant Hepatitis E virus-like particles presenting foreign epitopes as a novel vector of vaccine by oral administration / Yasuhiro Yasutomi -- ch. 21. Nucleocapsid protein of hantaviruses (Bunyaviridae): structure and functions / Alexander Plyusnin [und weitere] -- ch. 22. Astrovirus replication: an overview / Susana Guix, Albert Bosch and Rosa M. Pintó -- ch. 23. DNA vaccines against viruses / Britta Wahren and Margaret Liu -- ch. 24. Life cycles of polyomaviridae - DNA tumor virus / Masaaki Kawano, Hiroshi Handa and R. Holland Cheng

Structure and Physics of Viruses

Structure and Physics of Viruses
Author: Mauricio G. Mateu
Publisher: Springer Science & Business Media
Total Pages: 734
Release: 2013-06-04
Genre: Medical
ISBN: 9400765525
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This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.

Structural Biology for Virus Research

Structural Biology for Virus Research
Author: Akio Adachi
Publisher: Frontiers Media SA
Total Pages: 104
Release:
Genre:
ISBN: 2889190242
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Viruses are absolutely and strictly dependent on target host cells for their replication. However, they have their own unique strategies at each replication step from the entry into cells, transcription, translation, assembly of viral genome/proteins, and up to the release of progeny virions from cells. We virologists have to understand these complex biological interactions between viruses and host cells. Importantly, extensive studies based on bio-structural technology have revealed in succession the detailed and bottom line mechanisms of viral replication processes otherwise impossible. We now know the highly dynamic nature of viral genome/proteins, and are impressed by their ingeniously organized functionality in hostile host environments. For characterization of viruses as a unique genetic entity and pathogenic agent, it has been critical to investigate thoroughly the individual viral components and host factors involved in the virus replication cycle. Because many viral and cellular factors essential for viral replication and pathogenicity have been newly discovered through the efforts of virologists, the necessity of contribution to the progress of virology by the structural biology is now greatly increasing. To fully understand precise mechanisms underlying the functional interaction of viral and host molecules, needless to say, it is crucially required to have their structural information. We need to know molecular details of the nucleic acids, proteins, and interacting molecules. The information indispensable for understanding certain biological phenomena may only be provided by high-resolution three-dimensional structures. Of note, a number of anti-viral drugs have been generated based on the structural information. The interacting interfaces between virus and host components, which are important for viral replication, can be potent targets for anti-viral drugs. Their structural characterization would lead to designing rigid anti-viral drugs and/or vaccines. In this Research Topic, we wish to summarize and review what the structural biology has accomplished so far to resolve the important virological issues. We also wish to describe the perspective of the structural biology for the future virology. Finally, the presentation of ongoing original works is greatly encouraged.

Essential Human Virology

Essential Human Virology
Author: Jennifer Louten
Publisher: Academic Press
Total Pages: 412
Release: 2022-05-28
Genre: Science
ISBN: 0323914926
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Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays. Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology. Focuses on human diseases and the cellular pathology that viruses cause Highlights current and cutting-edge technology and associated issues Presents real case studies and current news highlights in each chapter Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses

Virus Structure

Virus Structure
Author:
Publisher: Elsevier
Total Pages: 610
Release: 2003-10-02
Genre: Science
ISBN: 0080493777
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Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. Covers viral assembly using heterologous expression systems and cell extracts Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment Includes information on structural studies on antibody/virus complexes

Assessment of Future Scientific Needs for Live Variola Virus

Assessment of Future Scientific Needs for Live Variola Virus
Author: Committee on the Assessment of Future Scientific Needs for Variola Virus
Publisher: National Academies Press
Total Pages: 126
Release: 1999-05-14
Genre: Medical
ISBN: 030959698X
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In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.

Human Herpesviruses

Human Herpesviruses
Author: Ann Arvin
Publisher: Cambridge University Press
Total Pages: 1325
Release: 2007-08-16
Genre: Medical
ISBN: 1139461648
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This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Viruses: Essential Agents of Life

Viruses: Essential Agents of Life
Author: Günther Witzany
Publisher: Springer Science & Business Media
Total Pages: 432
Release: 2012-11-13
Genre: Science
ISBN: 940074899X
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A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.