Structure And Shape Transitions In Pegylated Paclitaxel Loaded Cationic Liposomes Enhances Delivery And Cytotoxicity To Human Cancer Cells PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Structure And Shape Transitions In Pegylated Paclitaxel Loaded Cationic Liposomes Enhances Delivery And Cytotoxicity To Human Cancer Cells PDF full book. Access full book title Structure And Shape Transitions In Pegylated Paclitaxel Loaded Cationic Liposomes Enhances Delivery And Cytotoxicity To Human Cancer Cells.
| Author | : Cyrus R Safinya |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : |
Download Structure and Shape Transitions in PEGylated Paclitaxel-loaded Cationic Liposomes Enhances Delivery and Cytotoxicity to Human Cancer Cells Book in PDF, ePub and Kindle
Cationic Liposomes (CLs) are synthetic vectors for nucleic acid (NA) and drug delivery applications. CLs may be complexed with nucleic acids (DNA or short interfering RNA) for gene delivery and silencing, or used as vectors of cytotoxic hydrophobic drugs in cancer therapeutics. Primary among hydrophobic drugs is paclitaxel (PTX) a mitotic inhibitor that halts the proliferation of tumor cells during the cell cycle and induces cell death. We will describe the effect of PEGylation of paclitaxel-loaded cationic liposome (CLPTX) nanoparticles (NPs) on structure and NP shape, which, in turn, lead to modified interactions with human cancer cells and a dramatic enhancement of PTX delivery and cytotoxicity compared to bare CLPTX NPs. This enhancement occurs even though the PEG-chain coating the NP is in the mushroom to brush transition regime. These results are in contrast to PEGylated CL-DNA NPs employed in gene therapeutics, where the PEG coat suppresses cell entry.
| Author | : Vinod Kumar Yata |
| Publisher | : Springer Nature |
| Total Pages | : 340 |
| Release | : 2020-08-19 |
| Genre | : Technology & Engineering |
| ISBN | : 3030471209 |
Download Nanopharmaceuticals: Principles and Applications Vol. 3 Book in PDF, ePub and Kindle
This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
| Author | : Abdelbary Elhissi |
| Publisher | : Springer |
| Total Pages | : 92 |
| Release | : 2019-11-28 |
| Genre | : Science |
| ISBN | : 9783319012964 |
Download Proliposomes: A Manufacturing Technology of Liposomes for Pulmonary Delivery via Nebulization Book in PDF, ePub and Kindle
Proliposome technologies are stable phospholipid formulations that provide an approach to generating liposomes upon addition of aqueous phase prior to administration. In this monograph, the authors review the potential of proliposomes for pulmonary delivery of liposomes via nebulization using air-jet, ultrasonic and vibrating-mesh nebulizers. They explore both proliposome types, particulate-based and solvent-based. The book concludes that both types are capable of exploiting the energy of nebulization to generate liposomes within nebulizers.
| Author | : Norton B. Gilula |
| Publisher | : |
| Total Pages | : 242 |
| Release | : 1980 |
| Genre | : Science |
| ISBN | : |
Download Membrane-membrane Interactions Book in PDF, ePub and Kindle
| Author | : AlexanderT. Florence |
| Publisher | : Routledge |
| Total Pages | : 278 |
| Release | : 2017-10-05 |
| Genre | : Medical |
| ISBN | : 1351435043 |
Download Liposomes in Drug Delivery Book in PDF, ePub and Kindle
First Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.
| Author | : M. Reza Mozafari |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 238 |
| Release | : 2006-09-24 |
| Genre | : Medical |
| ISBN | : 1402050410 |
Download Nanocarrier Technologies Book in PDF, ePub and Kindle
Designed as an advanced survey of the field, this book describes the key research parameters of nanocarrier technologies. It is the first book with this topic. It comprises a collection of scientific articles from top research people in the field and provides an up-to-date source containing recent citation and bibliography. The book is an indispensable source of information for new researchers and scientists.
| Author | : Challa S. S. R. Kumar |
| Publisher | : Wiley-VCH |
| Total Pages | : 448 |
| Release | : 2006-07-24 |
| Genre | : Medical |
| ISBN | : |
Download Nanomaterials for Cancer Therapy Book in PDF, ePub and Kindle
This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.
| Author | : American Cancer Society |
| Publisher | : Jones & Bartlett Learning |
| Total Pages | : 596 |
| Release | : 2004 |
| Genre | : Cancer |
| ISBN | : 9780763732769 |
Download A Cancer Source Book for Nurses Book in PDF, ePub and Kindle
Covers the most common cancers and strategies for nursing care.
| Author | : Thomas J. Webster |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 245 |
| Release | : 2008-11-18 |
| Genre | : Technology & Engineering |
| ISBN | : 0387786082 |
Download Safety of Nanoparticles Book in PDF, ePub and Kindle
In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected. The aim of this book is to provide one of the first (if not the first) detailed views of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body through the skin. Only by compiling research at the intersection of nanoparticles and biological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications.
| Author | : Monika Schäfer-Korting |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 506 |
| Release | : 2010-03-10 |
| Genre | : Medical |
| ISBN | : 3642004776 |
Download Drug Delivery Book in PDF, ePub and Kindle
In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.
