Structural And Functional Imaging Of The Human And Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography PDF Download
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| Author | : Woo Jhon Choi |
| Publisher | : |
| Total Pages | : 225 |
| Release | : 2014 |
| Genre | : |
| ISBN | : |
Download Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography Book in PDF, ePub and Kindle
Optical coherence tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid noninvasively and in vivo, which have led OCT to be a clinical standard for the diagnosis of a variety of retinal diseases. Although current commercial Fourier domain OCT systems have high imaging speeds of 20-100kHz A-scan rates, these imaging speeds are not sufficient for more advanced structural and functional imaging techniques. Current state-of-the-art spectral domain and swept source OCT provide ultrahigh imaging speeds of >200kHz A-scan rates. These speeds enable functional imaging of retinal blood flow, OCT angiography of the retinal and choroidal microvasculature, and wide field volumetric structural imaging of the retina and choroid. In this thesis, advances in structural and functional ophthalmic imaging techniques for the human and small animal eyes are investigated using ultrahigh speed Fourier domain OCT. The following topics are discussed: (1) a method for numerically extracting and compensating dispersion mismatch in ultrahigh resolution spectral domain OCT, (2) ultrahigh speed spectral domain imaging in the small animal eye for measuring total retinal blood flow, (3) development of ultrahigh speed phase stable swept source OCT system for human retinal imaging, (4) OCT angiography of the choriocapillaris in the human eye, (5) clinical applications of OCT angiography in retinal diseases, including diabetic retinopathy and age-related macular degeneration, (6) small animal anesthesia protocol for functional hemodynamic imaging, and (7) imaging of neurovascular coupling in small animals using ultrahigh speed OCT.
| Author | : Vivek Jay Srinivasan |
| Publisher | : |
| Total Pages | : 468 |
| Release | : 2008 |
| Genre | : |
| ISBN | : |
Download High-speed Fourier Domain Optical Coherence Tomography for Structural and Functional Imaging of the Retina Book in PDF, ePub and Kindle
Optical Coherence Tomography (OCT) is an emerging optical biomedical imaging technology that enables cross-sectional imaging of scattering tissue with high sensitivity and micron-scale resolution. In conventional OCT, the reference arm path length in a Michelson interferometer is scanned in time to generate a profile of backscattering versus depth from the sample arm. In conventional OCT, a broadband, low coherence light source is used to achieve high axial resolution. However, clinical and research applications of conventional OCT have been limited by low imaging speeds. Recently, new Fourier domain OCT detection methods have enabled speeds of ~20,000-40,000 axial scans per second, which are ~50-100x faster than conventional OCT. These methods are called "Fourier domain" because they detect the interference spectrum and do not require mechanical scanning of the reference arm path length in time. In this thesis, two different technologies for Fourier domain OCT are investigated. The first technology, called spectral OCT, uses a broadband light source and a spectrometer to measure the interference spectrum. The second technology, called swept source OCT, uses a rapidly tunable narrowband laser to measure the interference spectrum over time. Applications of these new technologies for retinal imaging are illustrated, including three-dimensional retinal imaging in animal models, clinical imaging of retinal pathologies, quantification of photoreceptor morphology, and functional imaging of intrinsic stimulus-induced scattering changes in the retina. Finally, using a rapidly tunable laser, ultrahigh-speed swept source OCT imaging at 249,000 axial scans per second, roughly three orders of magnitude faster than conventional OCT, is demonstrated. This technology is applied for three-dimensional snapshots of the retina and optic nerve head and unprecedented visualization of retinal anatomy.
| Author | : Jonathan Jaoshin Liu |
| Publisher | : |
| Total Pages | : 142 |
| Release | : 2014 |
| Genre | : |
| ISBN | : |
Download Ultrahigh Speed Optical Coherence Tomography for Ophthalmic Imaging Applications Book in PDF, ePub and Kindle
Optical coherence tomography (OCT) is a non-contact, non-invasive, micron-scale optical imaging technology that has become a standard clinical tool in ophthalmology. Fourier domain OCT detection methods have enabled higher sensitivity and imaging speeds compared to previous generation timedomain OCT. Spectral / Fourier domain OCT (SD-OCT) detects the interference spectrum using a broadband light source and spectrometer. Swept-source / Fourier domain OCT (SS-OCT) detects the interference spectrum over time using a wavelength-swept laser. Current standard commercial ophthalmic clinical systems based on SD-OCT technology have imaging speeds of 20,000 - 40,000 axial scans per second and axial resolutions of 5 - 7 ptm. In this thesis, ultrahigh speed OCT for ophthalmic imaging applications are presented. SD-OCT systems using high speed CMOS camera technology can achieve imaging speeds over 70,000 axial scans per second. Axial resolutions better than 3 ptm can be achieved with multiplexed broadband superluminescent diodes. A novel registration motion-correction algorithm for volumetric OCT datasets reducing motion artifacts and improving signal quality is investigated. Ultrahigh speed, ultrahigh resolution SD-OCT ophthalmic imaging applications including small animal retinal imaging and clinical imaging of age-related macular degeneration (AMD) are illustrated. SS-OCT systems using short cavity wavelength-swept laser light sources can achieve imaging speeds over 100,000 axial scans per second with 6 pm axial resolution for small animal and clinical imaging. The high sensitivity of SS-OCT enables enhanced vitreous imaging, visualizing features in the vitreous and vitreoretinal interface. Finally, a new vertical cavity surface-emitting (VCSEL) technology based wavelength-swept laser light source SS-OCT system with tunable speed and wavelength range as well as long coherence length enabling ultrahigh speed and ultralong range OCT imaging applications is demonstrated. In addition to comprehensive structural imaging, the emergence of functional OCT imaging of retinal blood flow using ultrahigh speed OCT may also improve the understanding of ocular disease pathogenesis. Therefore, ultrahigh speed OCT is a promising tool for the diagnosis and management of diseases in ophthalmology.
| Author | : David Huang |
| Publisher | : SLACK Incorporated |
| Total Pages | : 290 |
| Release | : 2010 |
| Genre | : Medical |
| ISBN | : 1556429630 |
Download Imaging the Eye from Front to Back with RTVue Fourier-domain Optical Coherence Tomography Book in PDF, ePub and Kindle
Fourier-Domain optical coherence tomography (OCT) is the latest technology available to provide high-speed, high-resolution imaging of the cornea, anterior chamber angle, macula, and optic nerve head. It is uniquely suited for ophthalmologists that treat diseases from the front to the back of the eye. Inside Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography, Drs. David Huang, Jay S. Duker, James G. Fujimoto, Bruno Lumbroso, Joel S. Schuman, and Robert N. Weinreb cover up-to-date OCT technology and diagnostic software of the RTVue. It is the first book that covers clinical applications from the front to the back of the eye, as opposed to concentrating either on posterior segment imaging or anterior segment imaging. Inside you'll find: * Explanation of Fourier-Domain OCT technology * Teaching of scan pattern selection * Step-by-step instruction for scan acquisition * Teaching of the interpretations of OCT images and measurements by many case examples * Interpretation of en face images Some chapters covered: * Anterior segment * Cornea * Posterior segment * Retina * Age-related macular degeneration * Diabetic retinopathy * Glaucoma Imaging the Eye from Front to Back with RTVue Fourier-Domain Optical Coherence Tomography is the must-have book for general ophthalmologists, glaucoma specialists, retina specialists, cornea specialists, and refractive surgeons, as well as biomedical engineers.
| Author | : Fabian Kiessling |
| Publisher | : Springer |
| Total Pages | : 871 |
| Release | : 2017-05-22 |
| Genre | : Medical |
| ISBN | : 3319422022 |
Download Small Animal Imaging Book in PDF, ePub and Kindle
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
| Author | : Josef F. Bille |
| Publisher | : Springer |
| Total Pages | : 407 |
| Release | : 2019-08-13 |
| Genre | : Medical |
| ISBN | : 3030166384 |
Download High Resolution Imaging in Microscopy and Ophthalmology Book in PDF, ePub and Kindle
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
| Author | : Wolfgang Drexler |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1346 |
| Release | : 2008-12-10 |
| Genre | : Medical |
| ISBN | : 3540775501 |
Download Optical Coherence Tomography Book in PDF, ePub and Kindle
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
| Author | : Anand Vinekar |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 509 |
| Release | : 2012-10-30 |
| Genre | : Medical |
| ISBN | : 8131235823 |
Download Spectral-domain Optical Coherence Tomography Imaging of the Eye Book in PDF, ePub and Kindle
Spectral-domain Optical Coherence Tomography Imaging of the Eye is the first case-based atlas in its class: Covering over 120 clinical entities from the anterior to the posterior segment of the eye, from the most common to the rarest conditions Over 1000 descriptive high-resolution OCT images with clinical correlation Case report format for 'easy reading’ Over 100 Internationally reputed contributors Separate sections on Cornea, Lens, Glaucoma, Retina, Pediatric Retina, and Uvea
| Author | : Mark E. Brezinski |
| Publisher | : Elsevier |
| Total Pages | : 645 |
| Release | : 2006-08-25 |
| Genre | : Science |
| ISBN | : 0080464947 |
Download Optical Coherence Tomography Book in PDF, ePub and Kindle
Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.
| Author | : DaeYu Kim |
| Publisher | : |
| Total Pages | : |
| Release | : 2011 |
| Genre | : |
| ISBN | : 9781267028877 |
Download Fourier-domain Optical Coherence Tomography for in Vivo Human Retinal Imaging Book in PDF, ePub and Kindle
