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Strategies for Designing, Testing and Demonstrating Safety

Strategies for Designing, Testing and Demonstrating Safety
Author: Neelima Yeddanapudi
Publisher:
Total Pages: 101
Release: 2009
Genre:
ISBN:

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Synthetic biology is an emerging technology field within the realm of genetic engineering, differing from traditional genetic engineering in that it focuses on the modularization of genetic parts and the creation of de novo organisms. Significant concerns over safety have been expressed. This research explores traditional engineering and biotechnology practices for overarching principles of design, testing and demonstration that address safety concerns. The information is used to assess the current state of design, testing and demonstration in current synthetic biology projects addressing safety. Component and system design literature provide an engineering backbone of safety systems however, biological attributes such as mutation, growth, and multiplication create safety gaps, where biological engineering practices are needed. These principles are organized into categories of design and testing, and testing and demonstration to gain greater insight on where gaps in the literature might lie. Retrospective cases of traditional engineering and current cases of biotechnologies provide external validation and further illustrate which practices address which design, testing and demonstration needs. While most of the traditional engineering cases addressed safety through design and testing, when they were faced with questions of safety, they presented specific efforts to gain public confidence. The pro-biotics case was different in that the safety concerns came from the scientific community since history is being used as the convincing demonstration of safety. The three synthetic biology research projects cross the divide between traditional engineering and biotechnologies, but theses efforts are firmly in the area of design and testing. These efforts begin to show the tradeoff between implementing safety and faster technical results. Strategies for further research are explored.


An Effective Strategy for Safe Design in Engineering and Construction

An Effective Strategy for Safe Design in Engineering and Construction
Author: Andy Painting
Publisher: John Wiley & Sons
Total Pages: 212
Release: 2022-01-07
Genre: Technology & Engineering
ISBN: 1119832055

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AN EFFECTIVE STRATEGY FOR SAFE DESIGN IN ENGINEERING AND CONSTRUCTION Practically and efficiently implement the Construction (Design and Management) Regulations in any project In An Effective Strategy for Safe Design, safety and risk professionals David England and Dr Andy Painting provide a comprehensive exploration of the design process, from initial idea to the validation of the product in service, from a product and project safety perspective. In that context, the authors show how the appropriate implementation of the requirements of the Construction (Design and Management) Regulations 2015 can not only improve health and safety on a project but can also improve the project’s output as well as offering savings in both capital and operational expenditure. Readers will discover how the seemingly complex matters of regulation and risk management can be practically applied to projects via examples, illustrations, and real-world references. They will find out how safety regulation, standards, and initiatives all converge on the same goal—the safest output from any given project. The book achieves three primary goals: To improve the understanding and implementation of the Construction (Design and Management) Regulations 2015 To reduce errors during the design process via the effective implementation of design management strategy To embed the concept of safety in design Perfect for designers, design managers and supervisors, project managers, surveyors, and insurers, An Effective Strategy for Safe Design is also an invaluable addition to the libraries of principal designers, specifiers, and building control officers.


Design for Safety

Design for Safety
Author: Louis J. Gullo
Publisher: John Wiley & Sons
Total Pages: 532
Release: 2018-02-20
Genre: Technology & Engineering
ISBN: 1118974298

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A one-stop reference guide to design for safety principles and applications Design for Safety (DfSa) provides design engineers and engineering managers with a range of tools and techniques for incorporating safety into the design process for complex systems. It explains how to design for maximum safe conditions and minimum risk of accidents. The book covers safety design practices, which will result in improved safety, fewer accidents, and substantial savings in life cycle costs for producers and users. Readers who apply DfSa principles can expect to have a dramatic improvement in the ability to compete in global markets. They will also find a wealth of design practices not covered in typical engineering books—allowing them to think outside the box when developing safety requirements. Design Safety is already a high demand field due to its importance to system design and will be even more vital for engineers in multiple design disciplines as more systems become increasingly complex and liabilities increase. Therefore, risk mitigation methods to design systems with safety features are becoming more important. Designing systems for safety has been a high priority for many safety-critical systems—especially in the aerospace and military industries. However, with the expansion of technological innovations into other market places, industries that had not previously considered safety design requirements are now using the technology in applications. Design for Safety: Covers trending topics and the latest technologies Provides ten paradigms for managing and designing systems for safety and uses them as guiding themes throughout the book Logically defines the parameters and concepts, sets the safety program and requirements, covers basic methodologies, investigates lessons from history, and addresses specialty topics within the topic of Design for Safety (DfSa) Supplements other books in the series on Quality and Reliability Engineering Design for Safety is an ideal book for new and experienced engineers and managers who are involved with design, testing, and maintenance of safety critical applications. It is also helpful for advanced undergraduate and postgraduate students in engineering. Design for Safety is the second in a series of “Design for” books. Design for Reliability was the first in the series with more planned for the future.


Structure in Nature Is a Strategy for Design

Structure in Nature Is a Strategy for Design
Author: Peter Pearce
Publisher: MIT Press
Total Pages: 268
Release: 1990
Genre: Architecture
ISBN: 9780262660457

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"The structural designs that occur in nature - in molecules, in crystals, in living cells - appear in this fully illustrated book as a source of inspiration and study of design of man-made structures" -- BOOK JACKET.


Vaccine Design

Vaccine Design
Author: Gregory Gregoriadis
Publisher: Springer Science & Business Media
Total Pages: 205
Release: 2013-12-11
Genre: Medical
ISBN: 1489900624

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Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1996


Energy and Water Development Appropriations for 1985

Energy and Water Development Appropriations for 1985
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on Energy and Water Development
Publisher:
Total Pages: 1944
Release: 1984
Genre: Power resources
ISBN:

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Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry
Author: David J. am Ende
Publisher: John Wiley & Sons
Total Pages: 1431
Release: 2011-03-10
Genre: Technology & Engineering
ISBN: 1118088107

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This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.