Steroid Enzymes And Cancer Volume 1155 PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Steroid Enzymes And Cancer Volume 1155 PDF full book. Access full book title Steroid Enzymes And Cancer Volume 1155.

Steroid Enzymes and Cancer, Volume 1155

Steroid Enzymes and Cancer, Volume 1155
Author: H. Leon Bradlow
Publisher: Wiley-Blackwell
Total Pages: 360
Release: 2009-03-30
Genre: Family & Relationships
ISBN:
GET BOOK

Download Steroid Enzymes and Cancer, Volume 1155 Book in PDF, ePub and Kindle

The expression and activity of key enzymes of sex steroid metabolism have major implications in both development and progression of various human hormone-related tumors, including breast, prostate, lung, and liver cancer. This volume explores the role of local synthesis of steroid hormones, a process that has assumed an increasing importance in our understanding about several malignancies originating from steroid target tissues, wherein abnormal levels of individual steroids may promote tumor growth. In this framework, a divergent expression and/or activity of key gonadal steroid enzymes (including dehydrogenases, hydroxylases, sulfotransferases, sulfatases, and aromatase) may eventually lead to a differential accumulation of hormone derivatives with divergent biological activities in individual target tissues. This is of crucial importance in predicting the overall biological impact that sex steroids have on peripheral target tissues and, hence, on their potential role in cancer development and/or progression. The volume focuses on five key enzymes in the metabolism of sex steroids: (1) 17βhydroxysteroid dehydrogenase; (2) 5αreductase; (3) hydroxylases and catechol-oxy methyltransferase; (4) sulfatase, sulfotransferases, and glucuronidase; and (5) aromatase. The organization of the volume is designed to provide an updated picture of the existing knowledge about the association between steroid enzyme expression/function and the development and/or progression of major human cancers, including classical (breast, prostate) and nonclassical (lung, liver) hormone-related tumors. The resulting inferences for diagnosis, prognosis, and treatment are also presented, along with the experimental basis for developing preventive measures. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Anti-Aging Therapeutics Volume XV

Anti-Aging Therapeutics Volume XV
Author: A4M American Academy of Anti-Aging Medicine
Publisher: A4M American Academy of Anti-Aging Medicine
Total Pages: 230
Release: 2014-08-07
Genre: Medical
ISBN: 1934715158
GET BOOK

Download Anti-Aging Therapeutics Volume XV Book in PDF, ePub and Kindle

Proceedings of the Twentieth World Congress on Anti-Aging Medicine & Regenerative Biomedical Technologies, Spring and Winter Sessions

Sex Hormones

Sex Hormones
Author: Raghvendra Dubey
Publisher: BoD – Books on Demand
Total Pages: 446
Release: 2012-02-08
Genre: Medical
ISBN: 9533078561
GET BOOK

Download Sex Hormones Book in PDF, ePub and Kindle

Sex Hormones not only regulate reproductive function, but they also play a prominent role in the biology and physiology of several organs/tissues and in the pathophysiology of several diseases. During the last two decades, the information on the mechanisms of action of sex hormones, such as estrogens and androgens, has rapidly evolved from the conventional nuclear receptor dependent mechanisms to include additional non-nuclear, non-genomic and receptor-independent mechanisms. This highlights the need to update the current knowledge on sex hormones and their mode of action. Increasing evidence that exogenous/epigenetic factors can influence sex hormone production and action highlights the need to update our knowledge on the mechanisms involved. This book provides a systematic and updated overview of the male/female sex-hormones and their impact in the biology and physiology of various organs. Additionally, the book discusses their positive and negative association with the pathophysiology of various diseases (e.g. osteoporosis, cardiovascular-disease, hypogonadism, reproduction, cancer) and their therapeutic potential.

Pediatric Surgery, 2-Volume Set

Pediatric Surgery, 2-Volume Set
Author: Arnold G. Coran
Publisher: Elsevier Health Sciences
Total Pages: 1886
Release: 2012-02-14
Genre: Medical
ISBN: 0323072550
GET BOOK

Download Pediatric Surgery, 2-Volume Set Book in PDF, ePub and Kindle

Pediatric Surgery, 7th Edition - edited by Arnold G. Coran, Anthony Caldamone, N. Scott Adzick, Thomas M. Krummel, Jean-Martin Laberge, and Robert Shamberger - features comprehensive, up-to-date guidance on all aspects of childhood surgery, including congenital malformations, tumors, trauma, and urologic problems. Apply the latest developments in fetal surgery, adolescent bariatric surgery, minimally invasive surgery in children, and tissue engineering for the repair of congenital anomalies, such as the separation of conjoined twins. you can also access the fully searchable text online at www.expertconsult.com, making this definitive resource more accessible than ever. Get comprehensive coverage of cutting-edge technology in pediatric surgical diseases, including imaging concepts, minimally invasive techniques, robotics, diagnostic and therapeutic advances, and molecular biology and genetics. Find information quickly and easily with an intuitive organization by body region and organs. Apply the guidance of world-renowned experts in pediatric surgery. Access the fully searchable text online at www.expertconsult.com. Stay current on recent developments in fetal surgery, adolescent bariatric surgery, minimally invasive surgery in children, and tissue engineering for the repair of congenital anomalies, such as the separation of conjoined twins. Master the latest surgeries available for fetal and neonatal patients and provide life-saving options at birth. Tap into the expertise of new editors who bring fresh perspectives to cutting-edge techniques.

The Neuroendocrine Regulation of Behavior

The Neuroendocrine Regulation of Behavior
Author: Jay Schulkin
Publisher: Cambridge University Press
Total Pages: 340
Release: 1999
Genre: Science
ISBN: 9780521459853
GET BOOK

Download The Neuroendocrine Regulation of Behavior Book in PDF, ePub and Kindle

In this text Jay Schulkin discusses and emphasizes the important roles of steroids and neuropeptides in the regulation of behavior. The guiding principle behind much of the research and insights that are presented in the book is the concept of using certain model animal systems to study how hormones influence the brain. The results from these model systems can then be used to generalize the information obtained and apply it to other animals and humans. Senior undergraduate and graduate students in neuroscience, endocrinology, psychology, and physiology will find this text a useful guide to the role of hormones in behavior. It should be of use to colleagues in the field and medical health-care professionals.

Withrow and MacEwen's Small Animal Clinical Oncology

Withrow and MacEwen's Small Animal Clinical Oncology
Author: Stephen J. Withrow
Publisher: Elsevier Health Sciences
Total Pages: 775
Release: 2012-11-13
Genre: Medical
ISBN: 1437723624
GET BOOK

Download Withrow and MacEwen's Small Animal Clinical Oncology Book in PDF, ePub and Kindle

With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.

Proteostasis and Disease

Proteostasis and Disease
Author: Rosa Barrio
Publisher: Springer Nature
Total Pages: 350
Release: 2020-04-09
Genre: Science
ISBN: 3030382664
GET BOOK

Download Proteostasis and Disease Book in PDF, ePub and Kindle

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Enzyme Inhibition - Environmental and Biomedical Applications

Enzyme Inhibition - Environmental and Biomedical Applications
Author: G. Baskar
Publisher: Bentham Science Publishers
Total Pages: 321
Release: 2020-08-17
Genre: Science
ISBN: 9811460809
GET BOOK

Download Enzyme Inhibition - Environmental and Biomedical Applications Book in PDF, ePub and Kindle

Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for developing new therapeutic drugs. Most drugs treat various chronic and life threatening diseases owing to their specificity and the potency of enzymes which they can inhibit. Enzyme inhibitors are used to screen various levels of diseases which propel the growth of inhibitors. The potential for enzyme inhibitors in the therapeutics market is very high as the biochemical properties and classes of enzyme inhibiting products are readily available. The other broad aspect of enzyme inhibition is their application in analytical sensors. These sensors assist in monitoring various environmental factors. Understanding the mechanism of inhibition and regeneration of enzymes is a general problem of great importance for many biochemists and biotechnologists especially when using immobilized enzymes. This reference compiles applied information about enzyme inhibitors used in medicine and environmental monitoring applications. Chapters presented in this volume cover special topics including biosensors, crop improvements in agriculture, biofuel production, pesticide and heavy metal detection, and drug therapy for human diseases such as breast cancer, neurological diseases and viral infections. The collection of topics in this volume makes it an informative resource for readers at all academic levels on the applications of enzyme inhibitors in medicine and environmental sciences.

Transgender Medicine

Transgender Medicine
Author: Leonid Poretsky
Publisher: Springer
Total Pages: 481
Release: 2019-02-22
Genre: Medical
ISBN: 303005683X
GET BOOK

Download Transgender Medicine Book in PDF, ePub and Kindle

Although transgender persons have been present in various societies throughout human history, it is only during the last several years that they have become widely acknowledged in our society and their right to quality medical care has been established. In the United States, endocrinologists have been providing hormonal therapy for transgender individuals for decades; however, until recently, there has been only limited literature on this subject, and non-endocrine aspects of medical care for transgender individual have not been well addressed in the endocrine literature. The goal of this volume is not only to address the latest in hormonal therapy for transgender individuals (including pediatric and geriatric age groups), but also to familiarize the reader with other aspects of transgender care, including primary and surgical care, fertility preservation, and the management of HIV infection. In addition to medical issues, psychological, social, ethical and legal issues pertinent to transgender individuals add to the complexities of successful treatment of these patients. A final chapter includes extensive additional resources for both transgender patients and providers. Thus, an endocrinologist providing care to a transgender person will be able to use this single resource to address most of the patient’s needs. While Transgender Medicine is intended primarily for endocrinologists, this book will be also useful to primary care physicians, surgeons providing gender-confirming procedures, mental health professionals participating in the care of transgender persons, and medical residents and students.

Clinical Gynecology

Clinical Gynecology
Author: Eric J. Bieber
Publisher: Cambridge University Press
Total Pages: 1127
Release: 2015-04-23
Genre: Medical
ISBN: 1107040396
GET BOOK

Download Clinical Gynecology Book in PDF, ePub and Kindle

Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.