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Stereoselectivity of Pesticides

Stereoselectivity of Pesticides
Author: Everhardus Jacobus Ariëns
Publisher: Elsevier Publishing Company
Total Pages: 564
Release: 1988
Genre: Technology & Engineering
ISBN:

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Recently there has been growing concern about the hazards for man and his environment due to exposure to chemicals. One aspect receiving particular attention is that of the neglect of stereoselectivity in bioactive agents such as pesticides, drugs, etc. Mixtures of stereoisomers often contain 50 percent inactive material in the form of isomeric ballast. This ballast is pure environmental pollutant. Decisions as to whether the use of mixtures of stereoisomers is acceptable are only possible and acceptable if they are based on sound scientific information. It is the purpose of this volume to contribute to, and to disseminate, knowledge in this field. Written for workers in the field of pesticides, the book contains concise and basic information on stereoselectivity as a notable source of problems. Attention is paid to the involvement of stereoselectivity in important classes of pesticides as well as to pheromones and compounds derived from insect hormones with potential use in crop protection. Fundamentals of stereochemistry, stereoselective analytical methods, stereoselective synthesis and stereochemical aspects of the design of new compounds are also discussed.


Chiral Pesticides

Chiral Pesticides
Author: A. Wayne Garrison
Publisher: OUP USA
Total Pages: 0
Release: 2012-07-12
Genre: Science
ISBN: 9780841226791

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An examination of chirality as an environmental phenomenon


Chirality in Drug Design and Development

Chirality in Drug Design and Development
Author: Indra K. Reddy
Publisher: CRC Press
Total Pages: 406
Release: 2004-03-15
Genre: Science
ISBN: 0824751094

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Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.


Chirality in Agrochemicals

Chirality in Agrochemicals
Author: Norio Kurihara
Publisher: John Wiley & Sons
Total Pages: 292
Release: 1998-10-20
Genre: Technology & Engineering
ISBN: 0471981214

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Bisher gab es kein Buch, das sich speziell mit der Chiralität von Agrochemikalien beschäftigte, obwohl dieses Gebiet zunehmende Beachtung in der Industrie findet. Diese Darstellung der Chiralität bei Insektiziden, Fungiziden, Herbiziden und anderen Klassen von Agrochemikalien schließt diese Lücke. Synthese, Analytik, biologische Aktivität, Wirkprinzip, Toxikologie, Metabolismus und Umweltschicksal jeder besprochenen Verbindung werden diskutiert. (8/98)


Handbook of Chiral Chemicals

Handbook of Chiral Chemicals
Author: David Ager
Publisher: CRC Press
Total Pages: 632
Release: 2005-10-21
Genre: Medical
ISBN: 1420027301

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As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir


Basic Organic Stereochemistry

Basic Organic Stereochemistry
Author: Ernest L. Eliel
Publisher: Wiley-Interscience
Total Pages: 712
Release: 2001-04-11
Genre: Science
ISBN:

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A Practical Introduction to Stereochemistry Stereoisomers are compounds with the same chemical formula and connectivity but with different arrangements of their atoms in 3-dimensional space. Stereochemistry encompasses the study of stereoisomers and their properties. Despite having an identical chemical formula, stereoisomers can have drastically different biological, medicinal, and chemical properties. Basic Organic Stereochemistry explains in clear, concise terms the concepts and properties of stereoisomers. Ideal both as a text for advanced undergraduate or graduate students and as a handy guide for researchers in industry, this superb text covers: * Polarimetry and optical rotation * Internal coordinates, configuration, and conformation * Nature of stereoisomers * Barriers between stereoisomers and residual stereoisomers * Symmetry operators and symmetry point groups * Properties of stereoisomers and stereoisomer discrimination * Separation of stereoisomers, resolution, and racemization Suitable for students in organic and biological chemistry, Basic Organic Stereochemistry is unparalleled as a convenient text.


Chiral Environmental Pollutants

Chiral Environmental Pollutants
Author: Roland Kallenborn
Publisher: Springer Nature
Total Pages: 331
Release: 2021-01-29
Genre: Science
ISBN: 3030624560

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This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.


C-H Activation for Asymmetric Synthesis

C-H Activation for Asymmetric Synthesis
Author: Françoise Colobert
Publisher: John Wiley & Sons
Total Pages: 294
Release: 2019-11-11
Genre: Science
ISBN: 3527343407

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Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.


Chiral Organic Pollutants

Chiral Organic Pollutants
Author: Edmond Sanganyado
Publisher: CRC Press
Total Pages: 397
Release: 2020-12-30
Genre: Science
ISBN: 1000298884

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Chiral Organic Pollutants introduces readers to the growing challenges of chirality in synthetic chemicals. In this volume, contributors brilliantly summarize the characteristics of chiral pollutants to provide tools and techniques for effectively assessing their environmental and human health risks. Chapters cover recent research on the physicochemical properties, sources, exposure pathways, environmental fate, toxicity, and enantioselective analysis of chiral organic pollutants. Chiral Organic Pollutants also provides comprehensive discussions on the current trends in the synthesis and legislation of chiral chemicals. Key Features: Includes sampling and analytical methods for the enantioselective analysis of a wide array of chiral organic pollutants in food and the environment Summarizes recent research on the sources, fate, transport, and toxicity of chiral organic pollutants in the environment Critically examines the sources and pathways of chiral organic pollutants such as pesticides, pharmaceuticals, and flame retardants in food Includes a comprehensive discussion on current trends in the enantioselective synthesis and chiral switching of pesticides and pharmaceuticals Provides analysis of current national and international regulations of chiral synthetic chemicals The use of chiral synthetic chemicals such as pesticides, pharmaceuticals, personal care products, and halogenated flame retardants has significantly grown in the past 60 years. Hence, understanding the human and environmental health effects of chiral organic pollutants is crucial in the industry, academia, and policymaking. Chiral Organic Pollutants is an excellent textbook and reference for students, scientists, engineers, and policymakers interested in food quality, environmental pollution, chemical analysis, organic synthesis, and toxicology. Also available in the Food Analysis and Properties Series: Analysis of Nanoplastics and Microplastics in Food, edited by Leo. M.L. Nollet and Khwaja Salahuddin Siddiqi (ISBN: 9781138600188) Proteomics for Food Authentication, edited by Leo M.L. Nollet, and Semih Ötleş (ISBN: 9780367205058) Mass Spectrometry Imaging in Food Analysis, edited by Leo M.L. Nollet (ISBN: 9781138370692) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO