Stem Cell Migration PDF Download
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Author | : Marie-Dominique Filippi |
Publisher | : Humana Press |
Total Pages | : 0 |
Release | : 2011-06-01 |
Genre | : Science |
ISBN | : 9781617791444 |
Download Stem Cell Migration Book in PDF, ePub and Kindle
The migration of stem cells has been found to be critical during early development for the organization of the embryonic body as well as during adult life with tissue homeostasis and regeneration of organ function. Due to the low frequency of these cells in vivo, problems in identifying and prospectively purifying tissue specific stem cells near homogeneity, and, most importantly, a lack of adequate technologies and protocols to study stem cell migration in vivo, this vital research has been quite difficult until recently. In Stem Cell Migration: Methods and Protocols, experts in the field compile and highlight the standard and novel techniques that allow the studying of the migration of stem cells in one succinct manual. Including protocols on germ, neuronal, and hematopoietic stem cells, during development and adulthood with a clear emphasis on in vivo technologies, the volume also extends its coverage to in vitro approaches toward several developmentally-conserved signaling pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and convenient, Stem Cell Migration: Methods and Protocols provides key, state-of the art information on experimental techniques for studying stem cell migration both at a cellular and molecular level in development, regeneration, and disease.
Author | : Jenna Rose Fransioli |
Publisher | : |
Total Pages | : 78 |
Release | : 2007 |
Genre | : |
ISBN | : |
Download Tracking Stem Cell Migration in Pathologically Challenged Hearts Using GFP Tagged Stem Cells Book in PDF, ePub and Kindle
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 112 |
Release | : 2002-01-25 |
Genre | : Science |
ISBN | : 0309170427 |
Download Stem Cells and the Future of Regenerative Medicine Book in PDF, ePub and Kindle
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Author | : Hubert Wartenberg |
Publisher | : Springer |
Total Pages | : 90 |
Release | : 2018-12-12 |
Genre | : Science |
ISBN | : 3030020509 |
Download The Origin of a New Progenitor Stem Cell Group in Human Development Book in PDF, ePub and Kindle
This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs. The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets. These newly detected stem cells represent a specific developmental step which is found only in humans.
Author | : Grigorios Tsaknakis |
Publisher | : |
Total Pages | : 512 |
Release | : 2008 |
Genre | : Stem cells |
ISBN | : |
Download Molecular mechanisms of stem cell migration homing and engraftment Book in PDF, ePub and Kindle
Author | : Frank Entschladen |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 185 |
Release | : 2010 |
Genre | : Science |
ISBN | : 380559321X |
Download Cell Migration Book in PDF, ePub and Kindle
Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis. Covering extracellular regulatory signals and intracellular signal transduction pathways as well as the molecular mechanisms of migration in stem cells, leukocytes and tumor cells in the adult human organism, this book summarizes the current state of knowledge about cell migration. In the first part, the major aspects of different migratory cells in health and disease are covered, with special emphasis on T lymphocytes. The second part provides a comprehensive overview of the principal molecular mechanisms of migration such as adhesion receptors, cytoskeletal rearrangements and locomotor force generation, which, together, can be referred to as a cell's 'migrosome'.With contributions by eminent international scientists from different disciplines this book will serve as a valuable resource not only for researchers in cell biology, immunology and oncology, but also for clinicians who wish to learn more about the role of migratory processes in health and disease.
Author | : Ludovic Guillaume Jean-Marc Vincent |
Publisher | : |
Total Pages | : 198 |
Release | : 2014 |
Genre | : |
ISBN | : 9781321239096 |
Download Cell-matrix Interactions Regulate Adult Stem Cell Migration and Differentiation Book in PDF, ePub and Kindle
Stem cell therapies have shown promise in the treatment of musculoskeletal diseases by integrating with host tissue, remodeling diseased environments, and recruiting other cells through paracrine signaling. However, clinical trials have yielded limited success in part because the role of the extracellular matrix (ECM) has been underappreciated. The physiochemical properties of this protein network, notably the density, composition, and degree of crosslinking, all influence the Young's modulus, i.e. 'stiffness,' of this matrix. Cells 'feel' changes in their local environment by contracting against this material, integrating physical cues that guide cell function. In this thesis, we aim to elucidate how cell-matrix mechanosensing guides stem cell migration and differentiation. Our studies have employed synthetic hydrogels to decouple specific ECM properties, allowing us to study how each component independently regulates cell behavior. After fabricating hydrogels with mechanical gradients, we observed that stem cell migration velocity scaled with gradient strength over a given stiffness range as long as the cytoskeleton remained intact. This mechanical regulation of migration in normal and disease pathologies suggests that stem cells may better contribute to repairs in stiffer regions of tissues where they may preferentially accumulate. Mechanical step gradients provided a means to mechanically confine stem cells, which readily aligned and robustly underwent myogenic differentiation and fused, and could serve as a synthetic platform for micro tissue engineering constructs. Subsequent studies focused on cell-sensing in geometrically constrained environments. Tuning cell shape revealed that focal adhesion formation and cell-generated traction stresses follow opposing trends over a range of stiffness. Our contractility-based observations suggest that differentiation may be possible in non-permissive environments and could prove beneficial to treat fibrotic diseases. Further investigation on a microscopic scale of how cells interact with synthetic materials in vitro revealed that the substrate stiffness of our systems, and not the attached cell-adhesive ligands nor their configuration, was the most important factor to determine differentiation of stem cells. Taken together, these data imply that the mechanics of the environment drive biased cell migration and differentiation and that stem cell clinical trials may have higher chances of success if ECM mechanics are factored into the therapy design.
Author | : Yaoliang Tang |
Publisher | : Academic Press |
Total Pages | : 287 |
Release | : 2015-09-02 |
Genre | : Science |
ISBN | : 0128004975 |
Download Mesenchymal Stem Cell Derived Exosomes Book in PDF, ePub and Kindle
Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Author | : Douglas Ellis Wright |
Publisher | : |
Total Pages | : 288 |
Release | : 2001 |
Genre | : |
ISBN | : |
Download Hematopoietic Stem Cell Migration Book in PDF, ePub and Kindle
Author | : Krishnarao Appasani |
Publisher | : Springer Science & Business Media |
Total Pages | : 632 |
Release | : 2010-11-01 |
Genre | : Science |
ISBN | : 1607618605 |
Download Stem Cells & Regenerative Medicine Book in PDF, ePub and Kindle
Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.