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Stem Cell Biology in Normal Life and Diseases

Stem Cell Biology in Normal Life and Diseases
Author: Kamran Alimoghaddam
Publisher: BoD – Books on Demand
Total Pages: 198
Release: 2013-05-08
Genre: Science
ISBN: 9535111078

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Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).


Stem Cell Biology in Health and Disease

Stem Cell Biology in Health and Disease
Author: Thomas Dittmar
Publisher: Springer Science & Business Media
Total Pages: 428
Release: 2009-10-13
Genre: Medical
ISBN: 9048130409

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Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.


The Real Life Story of Stem Cells

The Real Life Story of Stem Cells
Author: Dr. Bhaskar Vyas & Dr. Rajni Vyas
Publisher: Dr. Bhaskar Vyas
Total Pages: 116
Release: 2020-08-10
Genre: Biography & Autobiography
ISBN:

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This book is an autobiographical narration of the research activities, with penchant and passion, by two leading clinicians who turned towards stem cell research in later years of their life. The book is about facts as they happened, it also includes fiction as it should be a part of any novel and there is fantasizing as well as what one would like to be in the future. Facts, fiction and fantasy are frequently flavoured with philosophy as well. The authors axiomatically classify themselves as philosophers. Advocating that philosophy is the mother of all disciplines, they narrate how they jumped into deep waters of expensive stem cell research. The book describes how did they blunder at times and also cites the appearance of guardian angels to salvage them. Floundering from cell biology to different kinds of stem cell applications, the book describes where they have now parked at a far horizon, on the edge of new discovery of a wonderful drug. They ignite a spark of caution with restrictive regulations. The book ends with reframing the poem by Rabindranath Tagore, ‘Into that heaven of regenerative medicine, my Father, let my country awake.’


Cell Biology and Translational Medicine, Volume 5

Cell Biology and Translational Medicine, Volume 5
Author: Kursad Turksen
Publisher: Springer
Total Pages: 172
Release: 2019-05-22
Genre: Science
ISBN: 3030175898

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Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fifth volume of a continuing series.


Adult Stem Cells

Adult Stem Cells
Author: Donald G. Phinney
Publisher: Springer Science & Business Media
Total Pages: 282
Release: 2011-02-11
Genre: Science
ISBN: 1617790028

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This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells, while it also describes and critically evaluates the methods currently used to assess stem cell self-renewal. The chapters also seek to distinguish this process from other aspects of cell survival, such as the regulation of life span, senescence, and immortalization at a molecular level. The monograph begins with a section that examine the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up. The second section details in-vivo lineage tracing of tissue-specific stem cells, explores the neural stem cell paradigm, and considers the function of ABC transporters and aldehyde dehydrogenase in adult stem-cell biology. The final section shifts the focus to the life-span regulation and immortalization and features a chapter on the cancer stem cell paradigm. This is an authoritative volume on one of the frontiers of genetic research, and will serve as a valuable resource, not just for established scientists but also for those now entering the field of stem cell biology.


Stem Cells and the Future of Regenerative Medicine

Stem Cells and the Future of Regenerative Medicine
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 112
Release: 2002-01-25
Genre: Science
ISBN: 0309170427

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Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.


Stem Cell Now

Stem Cell Now
Author: Christopher Thomas Scott
Publisher: Penguin
Total Pages: 273
Release: 2006-08-29
Genre: Science
ISBN: 1101213345

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THE STEM CELL IS SET TO DOMINATE POPULAR AWARENESS OF SCIENCE LIKE THE ATOM BOMB DID A GENERATION AGO. No area of science holds such immediate promise for treating disease and improving human lives as stem cell research. But no area of science also causes such fundamental ethical concern and such ferocious political conflict.


Stem Cells: Biology and Diseases

Stem Cells: Biology and Diseases
Author: Rex Turner
Publisher:
Total Pages: 0
Release: 2015-03-12
Genre:
ISBN: 9781632413611

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This book comprehensively discusses topics like biology and diseases related to the field of stem cells. Stem cells play an important role in our normal life as well as in the pathogenesis of disorders. Currently, these cells are clinically applicable in


Stem Cells and Cancer Stem Cells, Volume 7

Stem Cells and Cancer Stem Cells, Volume 7
Author: M.A. Hayat
Publisher: Springer Science & Business Media
Total Pages: 285
Release: 2012-06-12
Genre: Medical
ISBN: 9400742851

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The seventh in Springer’s landmark series of edited volumes on one of the highest-profile subjects in contemporary medicine and scientific endeavour, this volume sets out to cover a staggering range of research into the medical applications of stem cell research. While stem cells are the very stuff of life for multicellular organisms, including us humans, the cancer stem cell is a morbid entity with a robust resistance to therapies including conventional chemotherapy. This authoritative publication explains the regenerative potential of stem cells and their mesenchymal progeny, reviewing clinical applications of the latter in the treatment of cancer, diabetes and neurodegenerative pathologies. It covers the entire range of stem cells with known potential for therapeutic use, from human embryonic to germ cell-derived pluripotent stem cells and hematopoietic stem cells. The chapters also deal with the role of TGF-beta in propagating human embryonic stem cells, and in facilitating their differentiation. Featuring discussions of molecular signaling pathways that modulate mesenchymal stem cell self-renewal and much more, this book is certain to have broad appeal among academicians and physicians alike.


Essentials of Stem Cell Biology

Essentials of Stem Cell Biology
Author: Robert Lanza
Publisher: Academic Press
Total Pages: 681
Release: 2009-06-05
Genre: Science
ISBN: 0080884970

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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references