Stem And Progenitor Cells In The Central Nervous System PDF Download
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| Author | : R.S. Nowakowski |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 212 |
| Release | : 2004 |
| Genre | : Medical |
| ISBN | : 3805578709 |
Download Stem and Progenitor Cells in the Central Nervous System Book in PDF, ePub and Kindle
This publication focuses on the biology of stem and progenitor cells in the developing and mature central nervous system, their response to trauma and potential uses in therapy. The authors, who are leading experts in the field, address topical questions from both basic and clinical neuroscience perspectives such as: non-invasive imaging of stem cell division; the origins of regional diversity in cell types and cell numbers in the stem cell progeny; factors that regulate generation of neurons and glial cells from stem cells during normal development; the role of genetic and environmental factors in the regulation of stem cell function; the role of stem cells in mediating the effects of brain trauma and its recovery, and the therapeutic uses of stem cells. Offering a unique compilation of articles on the biology and the therapeutic applications of stem cells in the embryonic and mature nervous systems, this volume will be of great value to neuroscientists, developmental biologists, cancer biologists and clinical neurologists.
| Author | : F. Gage |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 203 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642803083 |
Download Isolation, Characterization and Utilization of CNS Stem Cells Book in PDF, ePub and Kindle
This volume is based on a meeting of the Fondation IPSEN, held in Paris on Sep tember 18, 1995 to address the main issues of nervous system stem cells biology. Cell replacement in the adult mammals is not unusual outside the nervous sys tem. In fact, the nervous system is unique in lacking the ability to replace cells, following damage. Most neurons, in the adult central nervous system are termin of the organism and are not replaced ally differentiated, exist through the life when they die. There are, however, regions of the postnatal brain that continue to produce new neurons, but the fate and longevity of those cells are not well known. Evidence exists that small populations of neurons continue to be born in the adult ventricular zone, olfactory epithelium and hippocampus. In the adult hippocampus, newly born neurons originate from putative stem cells that exist in the sub granular zone of the dentate gyrus. Progeny of these putative stem cells differentiate into neurons in the granular layer within a month of the cells' birth, and this late neurogenesis continues throughout the adult life of the rodent. By understanding the nature of progenitor cells present in the embryonic and adult brains, the change in their population dynamics during development, and the factors that influence their proliferation, fate choice and differentiation, it may be possible to develop a strategy to manipulate cells in situ to treat neuro degenerative diseases or the injured adult brain.
| Author | : Loic P. Deleyrolle |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2022-10-08 |
| Genre | : Medical |
| ISBN | : 9781071617854 |
Download Neural Progenitor Cells Book in PDF, ePub and Kindle
This updated edition collects cutting-edge techniques used to study neural stem and progenitor cells as well as the brain microenvironment. Featuring a wide range of technological advances in the study of neural stem cells, the volume highlights the promises of stem cell-based therapeutic applications for central nervous system ailments. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neural Progenitor Cells: Methods and Protocols, Second Edition serves as an invaluable resource for the next generation of neuroscientists as they develop innovative experimental paradigms and progress toward therapeutic applications in the field of neurobiology.
| Author | : Mahendra S. Rao |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 373 |
| Release | : 2001-02-20 |
| Genre | : Medical |
| ISBN | : 1592591078 |
Download Stem Cells and CNS Development Book in PDF, ePub and Kindle
Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.
| Author | : Damir Janigro |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 555 |
| Release | : 2008-01-23 |
| Genre | : Medical |
| ISBN | : 1597450219 |
Download The Cell Cycle in the Central Nervous System Book in PDF, ePub and Kindle
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
| Author | : Fred H. Gage |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 191 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642188834 |
Download Stem Cells in the Nervous System: Functional and Clinical Implications Book in PDF, ePub and Kindle
After 40 years of research, scientists have confirmed that persistent neurogenesis occurs in the adult mammalian brain. The obvious next question is: "Are the newly generated neurons functional?" If so, "What are the functions of these new neurons?" This volume intends to clarify both questions by providing the latest data available.
| Author | : Tanja Zigova |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 438 |
| Release | : 2002-11-05 |
| Genre | : Medical |
| ISBN | : 1592592988 |
Download Neural Stem Cells for Brain and Spinal Cord Repair Book in PDF, ePub and Kindle
Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
| Author | : Guilherme Lepski |
| Publisher | : |
| Total Pages | : 270 |
| Release | : 2012 |
| Genre | : |
| ISBN | : |
Download Stem Cells for Restoration of the Central Nervous System Book in PDF, ePub and Kindle
| Author | : Marie Vidal |
| Publisher | : |
| Total Pages | : 181 |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
Download In Search of the Optimal Cell for Central Nervous System Remyelination Book in PDF, ePub and Kindle
The development of therapies promoting myelin repair (by stimulation of endogenous remyelination and/or by transplantation of exogenous cells) would be a major advance for the treatment of multiple sclerosis, a demyelinating disease of the central nervous system (CNS). The present project explores the potential of peripheral nervous system (PNS) stem/progenitor cells for these innovative approaches in mouse models. Boundary cap cells (BCs) are embryonic PNS stem cells that are interesting candidates for cell therapy since they are highly competitive for CNS remyelination. However, their use is limited due to their difficult isolation. Therefore, we further investigated the potential presence of BC remnants in the adult PNS. We evidenced that adult dorsal root ganglia contain cells able to form multipotent spheres in vitro and exhibiting great differentiation plasticity in vivo. When grafted away from a demyelinated lesion in the spinal cord, they migrate to the lesion and differentiate into remyelinating Schwann cells as efficiently as BCs. Upon transplantation in the developing brain, they differentiate into pericytes. Finally, in order to identify these cells in situ we combined BrdU pulse chase assay and analysis of different transgenic tools. We identified a subpopulation of satellite glial cells exhibiting specific stem cells features. Fate-tracing experiments of these potential persistent adult PNS stem cells should provide crucial knowledge for the future development of therapies directed towards myelin repair.
| Author | : Jane E. Bottenstein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 479 |
| Release | : 2007-05-08 |
| Genre | : Medical |
| ISBN | : 0306483564 |
Download Neural Stem Cells Book in PDF, ePub and Kindle
Neural Stem Cells: Development and Transplantation provides comprehensive, critical and insightful reviews by leading experts in this exciting field of research. This volume will provide the latest data on neural stem cell properties and their therapeutic applications. This volume will be particularly useful for students, basic scientists, and clinicians in the academic or industrial sectors who have an interest in understanding neural development and its application to repairing the nervous system.
