Statistical Methods For Biodosimetry In The Presence Of Both Berkson And Classical Measurement Error PDF Download
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| Author | : Austin Miller |
| Publisher | : |
| Total Pages | : 239 |
| Release | : 2009 |
| Genre | : |
| ISBN | : |
Download Statistical Methods for Biodosimetry in the Presence of Both Berkson and Classical Measurement Error Book in PDF, ePub and Kindle
In radiation epidemiology, the true dose received by those exposed cannot be assessed directly. Physical dosimetry uses a deterministic function of the source term, distance and shielding to estimate dose. For the atomic bomb survivors, the physical dosimetry system is well established. The classical measurement errors plaguing the location and shielding inputs to the physical dosimetry system are well known. Adjusting for the associated biases requires an estimate for the classical measurement error variance, for which no data-driven estimate exists. In this case, an instrumental variable solution is the most viable option to overcome the classical measurement error indeterminacy. Biological indicators of dose may serve as instrumental variables. Specification of the biodosimeter dose-response model requires identification of the radiosensitivity variables, for which we develop statistical definitions and variables. More recently, researchers have recognized Berkson error in the dose estimates, introduced by averaging assumptions for many components in the physical dosimetry system. We show that Berkson error induces a bias in the instrumental variable estimate of the dose-response coefficient, and then address the estimation problem. This model is specified by developing an instrumental variable mixed measurement error likelihood function, which is then maximized using a Monte Carlo EM Algorithm. These methods produce dose estimates that incorporate information from both physical and biological indicators of dose, as well as the first instrumental variable based data-driven estimate for the classical measurement error variance.
| Author | : United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) |
| Publisher | : United Nations |
| Total Pages | : 512 |
| Release | : 2017-04-25 |
| Genre | : Political Science |
| ISBN | : 9210600029 |
Download Sources, Effects and Risks of Ionizing Radiation, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2016 Report Book in PDF, ePub and Kindle
This report assesses the levels and effects of exposure to ionizing radiation. Scientific findings underpin radiation risk evaluation and international protection standards. This report comprises a report with two underpinning scientific annexes. The first annex recapitulates and clarifies the philosophy of science as well as the scientific knowledge for attributing observed health effects in individuals and populations to radiation exposure, and distinguishes between that and inferring risk to individuals and populations from an exposure. The second annex reviews the latest thinking and approaches to quantifying the uncertainties in assessments of risk from radiation exposure, and illustrates these approaches with application to examples that are highly pertinent to radiation protection.
| Author | : Kory M. Ward |
| Publisher | : Amer. Assoc. for Clinical Chemistry |
| Total Pages | : 206 |
| Release | : 2003 |
| Genre | : Clinical Laboratory Techniques |
| ISBN | : 9781890883898 |
Download Clinical Diagnostic Technology Book in PDF, ePub and Kindle
| Author | : Wolfgang Ahrens |
| Publisher | : Springer |
| Total Pages | : 2498 |
| Release | : 2014-03-21 |
| Genre | : Medical |
| ISBN | : 9780387098357 |
Download Handbook of Epidemiology Book in PDF, ePub and Kindle
This 5-volume reference covers the entire field of epidemiology, from statistical methods and study design, to specialized areas such as molecular epidemiology, and applications in clinical medicine and health services research. This updated edition of the Handbook of Epidemiology adds 20 new chapters on: History of Epidemiological Methods and Concepts, Cluster Randomized Trials, Internet-Based Epidemiology, Misclassification, Sensitivity Analysis and Bias Analysis, Emergency and Disaster Health Surveillance, Statistical Inference, Data Management in Epidemiology, Bayesian Methods in Epidemiology, Generalized Estimating Equations, Directed Acyclic Graphs, Life Course Epidemiology, Physical Activity Epidemiology, Radiation Epidemiology, Epidemiology of Obesity, Epidemiology of Respiratory Allergies and Asthma, Epidemiology of Dental Diseases, Epidemiology of Digestive Diseases, Epidemiology of Psychiatric Disorders, Epidemiology of Diabetes. All other chapters are extensively revised from the 1st edition. This is a reference for epidemiological researchers and graduate students in public health.
| Author | : Peter Congdon |
| Publisher | : John Wiley & Sons |
| Total Pages | : 446 |
| Release | : 2005-12-13 |
| Genre | : Mathematics |
| ISBN | : 0470092386 |
Download Bayesian Models for Categorical Data Book in PDF, ePub and Kindle
The use of Bayesian methods for the analysis of data has grown substantially in areas as diverse as applied statistics, psychology, economics and medical science. Bayesian Methods for Categorical Data sets out to demystify modern Bayesian methods, making them accessible to students and researchers alike. Emphasizing the use of statistical computing and applied data analysis, this book provides a comprehensive introduction to Bayesian methods of categorical outcomes. * Reviews recent Bayesian methodology for categorical outcomes (binary, count and multinomial data). * Considers missing data models techniques and non-standard models (ZIP and negative binomial). * Evaluates time series and spatio-temporal models for discrete data. * Features discussion of univariate and multivariate techniques. * Provides a set of downloadable worked examples with documented WinBUGS code, available from an ftp site. The author's previous 2 bestselling titles provided a comprehensive introduction to the theory and application of Bayesian models. Bayesian Models for Categorical Data continues to build upon this foundation by developing their application to categorical, or discrete data - one of the most common types of data available. The author's clear and logical approach makes the book accessible to a wide range of students and practitioners, including those dealing with categorical data in medicine, sociology, psychology and epidemiology.
| Author | : Eugene Demidenko |
| Publisher | : John Wiley & Sons |
| Total Pages | : 880 |
| Release | : 2019-11-12 |
| Genre | : Mathematics |
| ISBN | : 1118387988 |
Download Advanced Statistics with Applications in R Book in PDF, ePub and Kindle
Advanced Statistics with Applications in R fills the gap between several excellent theoretical statistics textbooks and many applied statistics books where teaching reduces to using existing packages. This book looks at what is under the hood. Many statistics issues including the recent crisis with p-value are caused by misunderstanding of statistical concepts due to poor theoretical background of practitioners and applied statisticians. This book is the product of a forty-year experience in teaching of probability and statistics and their applications for solving real-life problems. There are more than 442 examples in the book: basically every probability or statistics concept is illustrated with an example accompanied with an R code. Many examples, such as Who said π? What team is better? The fall of the Roman empire, James Bond chase problem, Black Friday shopping, Free fall equation: Aristotle or Galilei, and many others are intriguing. These examples cover biostatistics, finance, physics and engineering, text and image analysis, epidemiology, spatial statistics, sociology, etc. Advanced Statistics with Applications in R teaches students to use theory for solving real-life problems through computations: there are about 500 R codes and 100 datasets. These data can be freely downloaded from the author's website dartmouth.edu/~eugened. This book is suitable as a text for senior undergraduate students with major in statistics or data science or graduate students. Many researchers who apply statistics on the regular basis find explanation of many fundamental concepts from the theoretical perspective illustrated by concrete real-world applications.
| Author | : Advisory Group on Ionising Radiation. Subgroup on Tritium Internal Dosimetry |
| Publisher | : |
| Total Pages | : 112 |
| Release | : 2007 |
| Genre | : Epidemiology |
| ISBN | : |
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| Author | : W. G. Eisert |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 343 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642693342 |
Download Biological Dosimetry Book in PDF, ePub and Kindle
In October 1982, a small international symposium was held at the Gesellschaft fUr Strahlen- und Umweltforschung mbH (GSF) in Munich as a satellite meeting of the IX International Conference on Analytical Cytology. The symposium focussed on cytometric approaches to biological dosimetry, and was, to the best of our knowledge, the first meeting on this subject ever held. There was strong encouragement from the 75 attendees and from others to publish a proceedings of the symposium. Hence this book, containing 30 of the 36 presentations, has been assembled. Dosimetry, the accurate and systematic determination of doses, usually refers to grams of substance administered or rads of ionization or some such measure of exposure of a patient, a victim or an experimental system. The term also can be used to describe the quantity of an ultimate, active agent as delivered to the appropriate target material within a biological system. Thus, for mutagens, one can speak of DNA dosimetry, meaning the number of adducts produced in the DNA of target cells such as bone-mar row stem cells or spermatogonia.
| Author | : Michael R. Hamblin |
| Publisher | : SPIE-International Society for Optical Engineering |
| Total Pages | : |
| Release | : 2017-11 |
| Genre | : Lasers |
| ISBN | : 9781510614154 |
Download Low-level Light Therapy Book in PDF, ePub and Kindle
"Low-level laser therapy (or photobiomodulation therapy) is a rapidly growing approach to treating a wide range of diseases and disorders that afflict humanity. This Tutorial Text covers the basic molecular and cellular mechanisms of action, applications for treating diseases in animal models, and its use in clinical trials and therapeutic practice in patients. Other topics include the two basic chromophores and how they trigger the signaling pathways, activation of transcription factors, and mobilization of stem cells; how the light-source design and the relevant energy parameters can affect the outcome of therapy; and the physics and tissue-optics principles that concern LLLT"--
| Author | : |
| Publisher | : |
| Total Pages | : 324 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : |
Download Sources and Effects of Ionizing Radiation Book in PDF, ePub and Kindle
