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Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis

Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis
Author: Charles C. Capen
Publisher:
Total Pages: 244
Release: 1999
Genre: Medical
ISBN:

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In November 1997, an expert group was convened to discuss available knowledge on the epidemiology, pathology and mechanisms related to certain tumors that are commonly seen in essays for carcinogenicity in rodents in order that their importance in human hazard evaluation might be assessed. The tumors of interest were urinary bladder carcinomas associated with urolithiasis, microcrystalluria and certain urinary precipitates; renal corticol tumors in male rats associated with alpha-2 urinary globulin nephropathy; and thyroid follicular cell tumors associated with imbalances in thyroid stimulating hormone. Included in the book are a series of individually authored papers on these various topics, as well as a Concensus Report including consideration of how such data may be used within the evalation process in the IARC Monographs on the Evaluation of Carcinogenic risks to Humans.


Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances

Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
Total Pages: 696
Release: 1999
Genre: Medical
ISBN:

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Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine


Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
Author: Wai Nang Choy
Publisher: CRC Press
Total Pages: 441
Release: 2001-08-31
Genre: Medical
ISBN: 113555420X

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Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard ide


Carcinogenicity

Carcinogenicity
Author: Kirk T. Kitchin
Publisher: CRC Press
Total Pages: 918
Release: 2021-12-17
Genre: Science
ISBN: 1000105466

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Offers comprehensive coverage of currently available cancer predictors, the most recent research on carcinogenicity, and the design and interpretation of carcinogenicity experiments. Presents mouse, rat, and human carcinogenicity data for the liver, kidney, breast, cervix, prostate, hematopoietic system, colon, skin, urinary bladder, mouth, stomach, thyroid, and pancreas.


Some Thyrotropic Agents

Some Thyrotropic Agents
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: World Health Organization
Total Pages: 774
Release: 2001
Genre: Health & Fitness
ISBN: 9283212797

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This publication represents the views and expert opinions of an IARC Working Group which met in Lyon, 10-17 October 2000.


Epigenetics and Human Health

Epigenetics and Human Health
Author: Alexander Haslberger
Publisher: John Wiley & Sons
Total Pages: 322
Release: 2011-08-24
Genre: Science
ISBN: 352764475X

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After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.


Disinfection By-Products and Human Health

Disinfection By-Products and Human Health
Author: Steve E. Hrudey
Publisher: IWA Publishing
Total Pages: 327
Release: 2012-04-30
Genre: Science
ISBN: 1843395193

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Disinfection By-Products and Human Health is based on contributions from speakers who participated in May 2011 workshops on Disinfection By-Products (DBPs) and Human Health at Ozwater 11 in Adelaide, Australia or at an AWA sponsored workshop at the Curtin Water Quality Research Centre, Perth, Australia. The contributions are prepared to facilitate communication with practitioners, rather than researchers, making use of overview illustrations rather than dense text or data tables. Each chapter concludes with up to 5 key findings that are take-home messages for practitioners. Disinfection By-Products and Human Health is aimed specifically at drinking water professionals (engineers, chemists and public health professionals) working on the front lines of drinking water issues where they must encounter actual day-to-day issues of risk management concerning DBPs in relation to all the other regulatory and water quality issues they must manage. Although a topic this complex is certainly not amenable to simplistic explanations, this book aims to provide drinking water professionals with a pragmatic assessment of the current evidence and emerging issues concerning DBPs and public health. Disinfection By-Products and Human Health is an essential, practical and accessible guide for drinking water professionals, engineers, chemists and public health professionals. Editors: Steve E. Hrudey, Professor Emeritus, Analytical & Environmental Toxicology, University of Alberta, Canada, Jeffrey W.A. Charrois, Director and Associate Professor, Curtin Water Quality Research Centre, Curtin University of Technology, Australia, Steve Hrudey is professor emeritus in analytical and environmental toxicology in the University of Alberta's Faculty of Medicine & Dentistry. He spent 13 years as a cabinet-appointed member of the Alberta Environmental Appeals Board, the last four as chair, and was the first non-lawyer to hold this position. During this period, he served on 36 public hearing panels, 19 as chair of the panel. In addition he has testified before senate committees in Canada and the Legislative Council in Western Australia. Hrudey has served on a number of high-profile expert panels, including the Research Advisory Panel to the Walkerton Inquiry (2000-2002), the Expert Panel on Safe Drinking Water for First Nations (2006), the Technical Advisory Committee to the B.C. Minister of Health on turbidity and microbial risk in drinking water (2007-2008, as chair), the Expert Advisory Panel on Water Quality for Washington, D.C., to the U.S. Army Corps of Engineers (2009-2011) and chair of the Royal Society of Canada Expert Panel on Environmental and Health Impacts of Canada's Oil Sands Industry (2009-2010). He has also co-authored or edited nine books, including the widely acclaimed book inspired by the Walkerton tragedy: Safe Drinking Water - Lessons from Recent Outbreaks in Affluent Nations (IWA Publishing, 2004). He has written 26 book chapters, 19 expert panel reports, 163 refereed journal articles, 15 science discussions, six media op-eds and 73 conference proceeding papers. Hrudey is the 2012 winner of the American Water Works Association A.P. Black Research Award for contributions to water science and water supply. This book is sponsored by Australian Water Association (AWA)


Toxicologic Pathology

Toxicologic Pathology
Author: Pritam S. Sahota
Publisher: CRC Press
Total Pages: 1019
Release: 2013-04-09
Genre: Medical
ISBN: 1439872104

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As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.


Cancer Risk Assessment

Cancer Risk Assessment
Author: Ching-Hung Hsu
Publisher: John Wiley & Sons
Total Pages: 727
Release: 2010-12-08
Genre: Science
ISBN: 1118035127

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With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.