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Species and Specificity

Species and Specificity
Author: Pauline M. H. Mazumdar
Publisher: Cambridge University Press
Total Pages: 480
Release: 2002-07-18
Genre: Science
ISBN: 9780521525237

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An account of scientific disputes over the core problems of research and practice in immunology.


Species and Specificity

Species and Specificity
Author: Pauline Margaret Hodgson Mazumdar
Publisher:
Total Pages: 457
Release: 1995
Genre: Immunology
ISBN:

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Their science was designed only in part to wrest an answer from nature: it was at least as important to wring an admission of defeat from their opponents. One of the key figures in the debate was the Austrian immunochemist Karl Landsteiner, whose career provides the central focus for Mazumdar's account. His unitarian views excluded him from promotion within European institutions, where the specificity and pluralism espoused by Robert Koch and Paul Ehrlich were entrenched. Landsteiner himself was forced into a kind of exile at Rockefeller University in New York. Though Landsteiner won a Nobel prize for his work, his inability to gain more widespread acceptance of his views caused him to view his life as a failure.


Janeway's Immunobiology

Janeway's Immunobiology
Author: Kenneth Murphy
Publisher: Garland Science
Total Pages:
Release: 2010-06-22
Genre: Medical
ISBN: 9780815344575

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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.


Immunology and Evolution of Infectious Disease

Immunology and Evolution of Infectious Disease
Author: Steven A. Frank
Publisher: Princeton University Press
Total Pages: 364
Release: 2002-07-21
Genre: Medical
ISBN: 9780691095950

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The Specificity of Serological Reactions

The Specificity of Serological Reactions
Author: Karl Landsteiner
Publisher: Courier Corporation
Total Pages: 348
Release: 2013-09-25
Genre: Science
ISBN: 0486151441

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Nobel prizewinner's account of experiments he and colleagues carried out on antigens and serological reactions with simple compounds. Exceptionally broad coverage of basic immunology. Extensive bibliography.


The Pangenome

The Pangenome
Author: Hervé Tettelin
Publisher: Springer Nature
Total Pages: 311
Release: 2020-04-30
Genre: Science
ISBN: 3030382818

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This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.


Joint Species Distribution Modelling

Joint Species Distribution Modelling
Author: Otso Ovaskainen
Publisher: Cambridge University Press
Total Pages: 389
Release: 2020-06-11
Genre: Nature
ISBN: 1108492460

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A comprehensive account of joint species distribution modelling, covering statistical analyses in light of modern community ecology theory.


Organ and Species Specificity in Chemical Carcinogenesis

Organ and Species Specificity in Chemical Carcinogenesis
Author: Robert Langenbach
Publisher: Springer Science & Business Media
Total Pages: 680
Release: 2013-11-21
Genre: Medical
ISBN: 146844400X

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The Symposium on Organ and Species Specificity in Chemical Carcinogenesis was held March 1981 in Raleigh, North Carolina. Dr. James Miller concluded this Symposium with these remarks: "Without a doubt all of us would agree this has been a very successful symposium in illustrating a very wide range of chemical, stereochemical, biochemical, metabolic, molecular, and biological factors in chemical carcinogenesis. I think it is noteworthy that many of the discussions have dealt with pharmacodynamic, or toxicodynamic, factors that can influence the biological activities of the extremely wide range of structures that we choose to call chemical carcinogens. I sincerely hope that after this symposium everyone here will realize the very great need we have for further information on these agents in the species we profess to be working for, the human species. We badly need an adequate data base on human organs, human tissues, human cells, human subcellular preparations, and human body fluids. I don't think we can rely on extrapolations of data on chemical carcinogenesis from experimental animals to humans, no matter how sophisticated or plausible these extrapolations may seem, until we know far more about chemical carcinogenesis in humans. Now, I'd like to add a somewhat personal note. As many of you know, my wife and I have shared a joint career of some 40 years in this field, and I'd like to emphasize in these closing remarks the factor of youth.


Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment
Author: National Research Council
Publisher: National Academies Press
Total Pages: 348
Release: 2000-12-21
Genre: Nature
ISBN: 0309070864

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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.