Somatic Genome Variation PDF Download
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Author | : Xiu-Qing Li |
Publisher | : John Wiley & Sons |
Total Pages | : 455 |
Release | : 2017-04-20 |
Genre | : Science |
ISBN | : 1118647025 |
Download Somatic Genome Variation Book in PDF, ePub and Kindle
Written by an international team of experts, Somatic Genome Variation presents a timely summary of the latest understanding of somatic genome development and variation in plants, animals, and microorganisms. Wide-ranging in coverage, the authors provide an updated view of somatic genomes and genetic theories while also offering interpretations of somatic genome variation. The text provides geneticists, bioinformaticians, biologist, plant scientists, crop scientists, and microbiologists with a valuable overview of this fascinating field of research.
Author | : |
Publisher | : |
Total Pages | : 450 |
Release | : 2013 |
Genre | : |
ISBN | : |
Download Somatic Genome Variation Book in PDF, ePub and Kindle
Author | : National Academies of Sciences, Engineering, and Medicine |
Publisher | : National Academies Press |
Total Pages | : 329 |
Release | : 2017-08-13 |
Genre | : Medical |
ISBN | : 0309452880 |
Download Human Genome Editing Book in PDF, ePub and Kindle
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
Author | : Thomas C. A. Smith |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
Download Within Genome Variation of Germ-line and Somatic Mutation Book in PDF, ePub and Kindle
Author | : Pierre Pontarotti |
Publisher | : Springer Nature |
Total Pages | : 389 |
Release | : 2020-10-29 |
Genre | : Science |
ISBN | : 3030572463 |
Download Evolutionary Biology—A Transdisciplinary Approach Book in PDF, ePub and Kindle
This book includes 16 selected contributions presented at the 23rd Evolutionary Biology Meeting, which took place in Marseille in September 2019. The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g. for medical research. The aim of these meetings is to promote the exchange of ideas to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
Author | : José María Frade |
Publisher | : Humana Press |
Total Pages | : 382 |
Release | : 2017-09-09 |
Genre | : Medical |
ISBN | : 9781493972791 |
Download Genomic Mosaicism in Neurons and Other Cell Types Book in PDF, ePub and Kindle
This volume presents methods for the analysis of genomic variability in vertebrate neurons and broadens our knowledge in the ways we understand the brain and its neurons. The chapters in this book are divided into 5 parts, and cover the following topics: principles and approaches for discovery of somatic mosaicism in the brain, aneuploidy and ploidy variation, DNA copy number variation, LINE-1 retrotransposition, and genetic and genomic mosaicism in aging and disease. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Genomic Mosaicism in Neurons and Other Cell Types is a valuable resource for learning about the latest techniques for the analysis of genome and genetic mosaicism in vertebrate neurons.
Author | : The Royal Society |
Publisher | : National Academies Press |
Total Pages | : 239 |
Release | : 2021-01-16 |
Genre | : Medical |
ISBN | : 0309671132 |
Download Heritable Human Genome Editing Book in PDF, ePub and Kindle
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author | : Thomas Curran |
Publisher | : Springer Science & Business Media |
Total Pages | : 171 |
Release | : 2010-12-16 |
Genre | : Medical |
ISBN | : 3642166024 |
Download Two Faces of Evil: Cancer and Neurodegeneration Book in PDF, ePub and Kindle
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
Author | : Antonio Morata |
Publisher | : BoD – Books on Demand |
Total Pages | : 298 |
Release | : 2019-09-04 |
Genre | : Technology & Engineering |
ISBN | : 1789846129 |
Download Advances in Grape and Wine Biotechnology Book in PDF, ePub and Kindle
Advances in Grape and Wine Biotechnology is a collection of fifteen chapters that addresses different issues related to the technological and biotechnological management of vineyards and winemaking. It focuses on recent advances in the field of viticulture with interesting topics such as the development of a microvine model for research purposes, the mechanisms of cultivar adaptation and evolution in a climate change scenario, and the consequences of vine water deficit on yield components. Other topics include the metabolic profiling of different Saccharomyces and non-Saccharomyces yeast species and their contribution in modulating the sensory quality of wines produced in warm regions, the use of new natural and sustainable fining agents, and available physical methods to reduce alcohol content. This volume will be of great interest to researchers and vine or wine professionals.
Author | : Elena Helman |
Publisher | : |
Total Pages | : 144 |
Release | : 2014 |
Genre | : |
ISBN | : |
Download Somatic Retrotransposition in the Cancer Genome Book in PDF, ePub and Kindle
Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput identification and characterization of these events genome-wide using computational algorithms. Retrotransposons comprise 42% of the human genome and have the capacity to "jump" across the genome in a copy-and-paste manner. Recent studies have identified families of retrotransposable elements that are currently active. In fact, retrotransposons constitute a major source of human genetic variation, and somatic retrotransposon insertions have been implicated in several cancers, including an insertion into the APC tumor suppressor in a colorectal tumor. Because of the highly repetitive nature of these elements, however, the full extent of somatic retrotransposon movement across cancer remains largely unexplored. To this end, we developed TranspoSeq, a computational framework that identifies retrotransposon insertions from paired-end whole genome sequencing data, and TranspoSeq- Exome, a tool that localizes these insertions from whole-exome data. TranspoSeq identifies novel somatic retrotransposon insertions with high sensitivity and specificity in simulated data and with a 94% validation rate via site-specific PCR. Next, we applied these methods to wholegenomes from 200 tumor/normal pairs and whole-exomes from 767 tumor/normal pairs across 11 tumor types as part of The Cancer Genome Atlas (TCGA) Pan-Cancer Project. We discover more than 800 somatic retrotransposon insertions primarily in lung squamous, head and neck, colorectal and endometrial carcinomas, while glioblastoma multiforme and acute myeloid leukemia show no evidence of somatic retrotransposition. Moreover, many somatic retrotransposon insertions occur in known cancer genes. TranspoSeq-Exome uncovers 35 additional somatic retrotransposon insertions into exonic regions, including an insertion into an exon of the PTEN tumor suppressor in endometrial cancer. Finally, we integrate orthogonal genomic and clinical data to characterize features of retrotransposon insertion and samples that exhibit extensive somatic retrotransposition. We present a large-scale, comprehensive analysis of retrotransposon movement across tumor types using next-generation sequencing data. Our results suggest that somatic retrotransposon insertions may represent an important class of tumor-specific structural variation in cancer and future studies should incorporate this form of somatic genome aberration.