Solubility And Solubilization In Aqueous Media PDF Download
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Author | : Samuel Hyman Yalkowsky |
Publisher | : Acs Professional Reference Boo |
Total Pages | : 0 |
Release | : 1999 |
Genre | : Medical |
ISBN | : 9780841235762 |
Download Solubility and Solubilization in Aqueous Media Book in PDF, ePub and Kindle
This book aims to provide the reader with a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium. The book begins with the factors which govern solubility in general and then looks at aqueous solubility in particular, including the properties of liquid mixtures and the thermodynamics of solutions formed from mixing two components. The bulk of the book is then devoted to techniques for altering solubility and dissolution rate of organic compounds in aqueous media. It discusses in detail the most commonly used solubility enhancers: buffers, cosolvents, surfactants, and complexants. Each chapter is self-contained and emphasizes the details for applying the techniques.
Author | : Gregory K. Webster |
Publisher | : CRC Press |
Total Pages | : 728 |
Release | : 2017-01-06 |
Genre | : Medical |
ISBN | : 9814745464 |
Download Poorly Soluble Drugs Book in PDF, ePub and Kindle
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Author | : Robert O. Williams III |
Publisher | : Springer Science & Business Media |
Total Pages | : 656 |
Release | : 2011-12-04 |
Genre | : Medical |
ISBN | : 1461411440 |
Download Formulating Poorly Water Soluble Drugs Book in PDF, ePub and Kindle
This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.
Author | : Amit Chaudhary |
Publisher | : LAP Lambert Academic Publishing |
Total Pages | : 52 |
Release | : 2012 |
Genre | : |
ISBN | : 9783659211577 |
Download Enhancement of Solubilization & Bioavailability of Poorly Soluble Drug Book in PDF, ePub and Kindle
The aim of this work is to improve the solubilization and bioavailability of poorly soluble drugs by using various approaches like physical, chemical and others modifications or techniques. The solubility of a solute is the maximum quantity of solute that can dissolve in a certain quantity of solvent or quantity of solution at a specified temperature. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parenterally, topically and orally administered solutions. Physical modifications techniques like media milling/ nanocrystal technology, cryogenic technology, supercritical fluid process, modification of the crystal habit, complexation, micellar technologies, chemical modifications etc.
Author | : Peter Howard Elworthy |
Publisher | : |
Total Pages | : 340 |
Release | : 1968 |
Genre | : Solubility |
ISBN | : |
Download Solubilization by Surface-active Agents and Its Applications in Chemistry and the Biological Sciences Book in PDF, ePub and Kindle
Author | : Abolghasem Jouyban |
Publisher | : CRC Press |
Total Pages | : 554 |
Release | : 2009-08-26 |
Genre | : Medical |
ISBN | : 1439804885 |
Download Handbook of Solubility Data for Pharmaceuticals Book in PDF, ePub and Kindle
Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab
Author | : Zhenbo Xu |
Publisher | : BoD – Books on Demand |
Total Pages | : 140 |
Release | : 2017-11-29 |
Genre | : Science |
ISBN | : 9535136496 |
Download Solubility of Polysaccharides Book in PDF, ePub and Kindle
Sugars, with a scientific term as saccharides, are involved in various aspects in the lives of human beings, including the sense of taste, energy for daily life, etc. Recent development in polysaccharides, as well as the background knowledge in this field, further deepens insight into their roles as healthy supplements. In this book, the principles on polysaccharides' solubility and structure, methodologies and application of polysaccharides have been reviewed. The chapters in this book include the relationship between structure and solubility of polysaccharide, the experimental and computational researches on polysaccharide solubility and the common polysaccharide, which may further aid scholars and researchers in regard to solubility of polysaccharides, methodologies and modification.
Author | : G. T. Hefter |
Publisher | : John Wiley & Sons |
Total Pages | : 657 |
Release | : 2003-08-01 |
Genre | : Science |
ISBN | : 0471497088 |
Download The Experimental Determination of Solubilities Book in PDF, ePub and Kindle
* Guidelines are provided on the reliability of various methods, as well as information for selecting the appropriate technique. * Unique coverage of the whole range of solubility measurements. * Very useful for investigators interested in embarking upon solubility measurements.
Author | : Gregory K. Webster |
Publisher | : Jenny Stanford Publishing |
Total Pages | : 0 |
Release | : 2016-12-16 |
Genre | : Bioavailability |
ISBN | : 9789814745451 |
Download Poorly Soluble Drugs Book in PDF, ePub and Kindle
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Author | : Navnit Shah |
Publisher | : Springer |
Total Pages | : 702 |
Release | : 2014-11-21 |
Genre | : Medical |
ISBN | : 1493915983 |
Download Amorphous Solid Dispersions Book in PDF, ePub and Kindle
This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.