Signaling Pathways And Molecular Mediators In Metastasis PDF Download
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Author | : Alessandro Fatatis |
Publisher | : Springer Science & Business Media |
Total Pages | : 373 |
Release | : 2012-01-02 |
Genre | : Medical |
ISBN | : 9400725582 |
Download Signaling Pathways and Molecular Mediators in Metastasis Book in PDF, ePub and Kindle
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
Author | : |
Publisher | : Springer |
Total Pages | : 388 |
Release | : 2012-01-21 |
Genre | : |
ISBN | : 9789400725591 |
Download Signaling Pathways and Molecular Mediators in Metastasis Book in PDF, ePub and Kindle
Author | : Antonella Zannetti |
Publisher | : Frontiers Media SA |
Total Pages | : 566 |
Release | : 2021-09-30 |
Genre | : Medical |
ISBN | : 2889714489 |
Download Tumor Microenvironment: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression Book in PDF, ePub and Kindle
Author | : Alessandro Fatatis |
Publisher | : Springer Science & Business Media |
Total Pages | : 373 |
Release | : 2012-01-03 |
Genre | : Medical |
ISBN | : 9400725574 |
Download Signaling Pathways and Molecular Mediators in Metastasis Book in PDF, ePub and Kindle
This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
Author | : Anna Mourskaia |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : |
ISBN | : |
Download Molecular Mediators of Breast Cancer Bone Metastasis Book in PDF, ePub and Kindle
"Breast cancer is the most frequently diagnosed and the second leading cause of cancer deaths in Canadian women. The most devastating and deadly feature of the disease is the emergence of metastases. Breast cancer most commonly metastasizes to bone, often leading to a significantly decreased quality of life in affected patients. Despite progress in understanding the underlying molecular biology of breast tumors that relapse to bone, to date there are no therapies capable of curing the disease. Hence, it is essential to gain a more in-depth knowledge of the molecular mechanisms that underlie the emergence and growth of breast cancer skeletal metastases. Consequently, it was attempted to: 1) examine the efficacy of targeting a known pathway important for breast cancer metastasis to bone, 2) identify novel mediators of this process and 3) develop a stratification tool capable of identifying patients with breast cancer that possesses a high likelihood of spreading to bone. Transforming growth factor-beta (TGF-[beta]) signaling is a potent modulator of the invasive and metastatic behavior of breast cancer cells. The work in this thesis demonstrates that expression of a TGF-[beta] ligand trap, which neutralizes TGF-[beta]1 and TGF-[beta]3 in breast cancer cells, diminished their outgrowth in bone and reduced the severity of osteolytic lesion formation. It is further shown that a reduction or loss of host-derived TGF-[beta]1 reduced the incidence of breast tumor outgrowth in the skeleton. Moreover, tumor cells capable of growing within the bone of a TGF-[beta]1 deficient host up-regulated expression of all three TGF-[beta] isoforms within the tumor cells themselves, effectively bypassing the host-deficiency. Next, a gene discovery approach was undertaken to identify novel candidate mediators of breast cancer skeletal metastasis. Invasive breast epithelium was selectively isolated by laser capture microdissection (LCM) performed on bone metastases and primary tumors from patients displaying breast cancer with subsequent recurrence to the skeleton. In this search, ABCC5 was found to be overexpressed in osseous metastases compared to primary mammary tumors metastatic to bone. Furthermore, this protein was detected at substantially higher levels in human and mouse breast cancer cells, which metastasize to bone in animal models. Importantly, removal of this protein from these cells resulted in their decreased ability to induce osteolytic bone lesions, which was correlated with a decreased recruitment of osteoclasts, cells responsible for the bone resorption process. Finally, the molecular changes occurring within the primary breast tumor were investigated in an attempt to identify a prognostic bone metastatic signature. Gene expression profiling was performed on estrogen receptor (ER)-positive primary breast tumors metastastatic to bone and breast cancers, which spread to soft tissue. A 25-gene signature was derived from the top 100 differentially expressed probes and was found to be capable of discriminating breast tumors metastatic to bone from cancers recurring to visceral sites in an independent gene expression dataset." --
Author | : David A. Frank |
Publisher | : Springer Science & Business Media |
Total Pages | : 358 |
Release | : 2002-12-31 |
Genre | : Medical |
ISBN | : 1402073402 |
Download Signal Transduction in Cancer Book in PDF, ePub and Kindle
One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Author | : Bharat B. Aggarwal |
Publisher | : Springer |
Total Pages | : 489 |
Release | : 2014-05-12 |
Genre | : Medical |
ISBN | : 3034808372 |
Download Inflammation and Cancer Book in PDF, ePub and Kindle
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author | : Sam Thiagalingam |
Publisher | : Cambridge University Press |
Total Pages | : 597 |
Release | : 2015-04-09 |
Genre | : Mathematics |
ISBN | : 0521493390 |
Download Systems Biology of Cancer Book in PDF, ePub and Kindle
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author | : Rahul Jandial |
Publisher | : CRC Press |
Total Pages | : 312 |
Release | : 2013-08-08 |
Genre | : Medical |
ISBN | : 9781587066597 |
Download Metastatic Cancer: Clinical and Biological Perspectives Book in PDF, ePub and Kindle
Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Author | : Adriano Rossi |
Publisher | : Springer Science & Business Media |
Total Pages | : 246 |
Release | : 2008-03-17 |
Genre | : Medical |
ISBN | : 376437506X |
Download The Resolution of Inflammation Book in PDF, ePub and Kindle
This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.