Rnai Technologies PDF Download
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Author | : R. K. Gaur |
Publisher | : CRC Press |
Total Pages | : 0 |
Release | : 2011-04-28 |
Genre | : Science |
ISBN | : 9781578087167 |
Download RNAi Technology Book in PDF, ePub and Kindle
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA interference in microorganisms, plants, and animals, this book reviews the selective and robust effect of RNAi on gene expression. This process is essential both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest.
Author | : Prerna Pandey |
Publisher | : Delve Publishing |
Total Pages | : 0 |
Release | : 2017-11 |
Genre | : Gene silencing |
ISBN | : 9781773611471 |
Download RNAi Technologies Book in PDF, ePub and Kindle
RNA interference (RNAi), one of the most exciting discoveries of the last decade, is also known as Post-Transcriptional Gene Silencing (PTGS). It is a conserved host defense response via double-stranded RNA against both endogenous and foreign nucleic acids, and occurs at the levels of transcription, post-transcription and translation. RNA induced gene silencing has been used, with considerable success as a reverse genetics tool for the study of gene function. This technology has revolutionized the gene expression analysis studies because of the specificity and speed it offers. The small RNA molecules central to RNAi are microRNA (miRNA) and small interfering RNA (siRNA). These molecules bind to other RNAs specifically, such as messenger RNA (mRNA), to regulate their activities.In this book, we will discuss how gene silencing methodology has been successfully applied as therapeutic tool against metabolic disorders, cancer, and infectious diseases. This tool has also been successfully used to improve crops resistance against plant pathogens. In contrast to conventional knock-out mutagenesis techniques, the "gene-silencing" vectors, that allow the study of functions of genes whose complete knock-out would otherwise be lethal to the plant.
Author | : R. K. Gaur |
Publisher | : CRC Press |
Total Pages | : 380 |
Release | : 2016-04-19 |
Genre | : Science |
ISBN | : 1439873259 |
Download RNAi Technology Book in PDF, ePub and Kindle
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
Author | : Volker A. Erdmann |
Publisher | : Springer Science & Business Media |
Total Pages | : 460 |
Release | : 2010-09-02 |
Genre | : Medical |
ISBN | : 3642121683 |
Download RNA Technologies and Their Applications Book in PDF, ePub and Kindle
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Author | : Kamel A Abd-Elsalam |
Publisher | : Elsevier |
Total Pages | : 842 |
Release | : 2021-02-27 |
Genre | : Technology & Engineering |
ISBN | : 0128219114 |
Download CRISPR and RNAi Systems Book in PDF, ePub and Kindle
Plants are vulnerable to pathogens including fungi, bacteria, and viruses, which cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is frequently cited as the most encouraging application of CRISPR/Cas9 technology in agriculture. Nanobiotechnology has harnessed the power of genome editing to develop agricultural crops. Nanosized DNA or RNA nanotechnology approaches could contribute to raising the stability and performance of CRISPR guide RNAs. This book brings together the latest research in these areas. CRISPR and RNAi Systems: Nanobiotechnology Approaches to Plant Breeding and Protection presents a complete understanding of the RNAi and CRISPR/Cas9 techniques for controlling mycotoxins, fighting plant nematodes, and detecting plant pathogens. CRISPR/Cas genome editing enables efficient targeted modification in most crops, thus promising to accelerate crop improvement. CRISPR/Cas9 can be used for management of plant insects, and various plant pathogens. The book is an important reference source for both plant scientists and environmental scientists who want to understand how nano biotechnologically based approaches are being used to create more efficient plant protection and plant breeding systems. Shows how nanotechnology is being used as the basis for new solutions for more efficient plant breeding and plant protection Outlines the major techniques and applications of both CRISPR and RNAi technologies Assesses the major challenges of escalating these technologies on a mass scale
Author | : Muhammad Sohail |
Publisher | : CRC Press |
Total Pages | : 398 |
Release | : 2004-08-27 |
Genre | : Medical |
ISBN | : 020348925X |
Download Gene Silencing by RNA Interference Book in PDF, ePub and Kindle
Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r
Author | : Susana Araújo |
Publisher | : Frontiers Media SA |
Total Pages | : 103 |
Release | : 2021-07-28 |
Genre | : Science |
ISBN | : 2889711005 |
Download Advances and Challenges of RNAi Based Technologies for Plants Book in PDF, ePub and Kindle
Author | : Aditi Singh |
Publisher | : BoD – Books on Demand |
Total Pages | : 136 |
Release | : 2019-05-29 |
Genre | : Medical |
ISBN | : 1838806962 |
Download Modulating Gene Expression Book in PDF, ePub and Kindle
RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.
Author | : Krishnarao Appasani |
Publisher | : Cambridge University Press |
Total Pages | : 564 |
Release | : 2005-01-17 |
Genre | : Science |
ISBN | : 9781139442657 |
Download RNA Interference Technology Book in PDF, ePub and Kindle
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
Author | : Bruno Mezzetti |
Publisher | : Frontiers Media SA |
Total Pages | : 168 |
Release | : 2022-08-04 |
Genre | : Science |
ISBN | : 2889767175 |
Download Advances and Challenges of RNAi Based Technologies for Plants - Volume 2 Book in PDF, ePub and Kindle