Rna Methylation PDF Download
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Author | : Alexandra Lusser |
Publisher | : Humana Press |
Total Pages | : 304 |
Release | : 2017-03-28 |
Genre | : Medical |
ISBN | : 9781493968053 |
Download RNA Methylation Book in PDF, ePub and Kindle
This volume provides a comprehensive collection of current methods and protocols to study posttranscriptional base modifications in RNA with special focus on methylation. The protocols in this book discuss state-of-the-art methods for investigating aspects of RNA methylation on different types of RNA. The protocols cover topics such as wet-lab techniques for the detection of methylation, instructions for bioinformatics analyses of transcriptome-scale data, and protocols for the functional examination of RNA modifications and enzymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, RNA Methylation: Methods and Protocols is a valuable resource for biochemists and molecular biologists, from various fields, who wish to investigate different types of RNA methylations.
Author | : Anica Dricu |
Publisher | : Inst za onkologiju i radiol |
Total Pages | : 311 |
Release | : 2012-11-28 |
Genre | : Medical |
ISBN | : 9535108816 |
Download Methylation Book in PDF, ePub and Kindle
Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain.
Author | : Emanuele Buratti |
Publisher | : Frontiers Media SA |
Total Pages | : 77 |
Release | : 2020-02-03 |
Genre | : |
ISBN | : 2889633101 |
Download Role of RNA Modification in Disease Book in PDF, ePub and Kindle
Author | : Stefan Jurga |
Publisher | : Springer Nature |
Total Pages | : 624 |
Release | : 2019-08-28 |
Genre | : Medical |
ISBN | : 3030147924 |
Download The DNA, RNA, and Histone Methylomes Book in PDF, ePub and Kindle
This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Author | : |
Publisher | : Academic Press |
Total Pages | : 441 |
Release | : 2015-12-11 |
Genre | : Science |
ISBN | : 0128023317 |
Download RNA Modification Book in PDF, ePub and Kindle
RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today. Dynamic RNA modifications and their roles in biological regulation are the current frontier of life science research This volume of Methods in Enzymology represents up to date knowledge and protocols
Author | : Vincenzo E. A. Russo |
Publisher | : |
Total Pages | : 716 |
Release | : 1996 |
Genre | : Medical |
ISBN | : |
Download Epigenetic Mechanisms of Gene Regulation Book in PDF, ePub and Kindle
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Author | : Giovanni Nigita |
Publisher | : Frontiers Media SA |
Total Pages | : 127 |
Release | : 2019-01-31 |
Genre | : |
ISBN | : 2889457419 |
Download Epitranscriptomics: The Novel RNA Frontier Book in PDF, ePub and Kindle
Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.
Author | : Stefan Jurga |
Publisher | : Springer Nature |
Total Pages | : 632 |
Release | : 2021-07-28 |
Genre | : Science |
ISBN | : 3030716120 |
Download Epitranscriptomics Book in PDF, ePub and Kindle
This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
Author | : M.A. Matzke |
Publisher | : Springer Science & Business Media |
Total Pages | : 297 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9401141835 |
Download Plant Gene Silencing Book in PDF, ePub and Kindle
This book is an up-to-date and comprehensive collection of reviews on various aspects of epigenetic gene silencing in plants. Research on this topic has undergone explosive growth during the past decade and has revealed novel features of gene regulation and plant defense responses that also apply to animals and fungi. Gene silencing is relevant for agricultural biotechnology because stable expression of transgenes is required for the successful commercialization of genetically engineered crops. The reviews have been written by distinguished authors who have made significant contributions to plant gene silencing research. This volume supersedes other books on gene silencing by focussing on plant systems, where many pioneering experiments have been performed, and by including the latest developments from top laboratories. The book is geared toward advanced students of genetics and plant sciences as well as applied and basic research scientists who work with transgenic organisms and epigenetic regulation of gene expression.
Author | : Xiao Han |
Publisher | : Frontiers Media SA |
Total Pages | : 387 |
Release | : 2022-05-05 |
Genre | : Science |
ISBN | : 2889761061 |
Download RNA Modifications and Epitranscriptomics Book in PDF, ePub and Kindle