Rna From Sequence To Structure And Dynamics PDF Download
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Author | : Jienyu Ding |
Publisher | : Springer Nature |
Total Pages | : 256 |
Release | : 2022-10-13 |
Genre | : Science |
ISBN | : 1071626876 |
Download RNA Structure and Dynamics Book in PDF, ePub and Kindle
This volume provides a wide spectrum of multidisciplinary approaches for studying RNA structure and dynamics, including detailed accounts of experimental and computational procedures. Chapters guide readers through cryo-electron microscopy, crystallography, isothermal titration calorimetry, small angle X-ray scattering, single-molecule Förster Energy transfer, X-ray free electron laser, atomic force microscopy, computational simulation, and prediction. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, RNA Structure and Dynamics aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.
Author | : Neocles Leontis |
Publisher | : Springer Science & Business Media |
Total Pages | : 402 |
Release | : 2012-06-05 |
Genre | : Science |
ISBN | : 3642257402 |
Download RNA 3D Structure Analysis and Prediction Book in PDF, ePub and Kindle
With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.
Author | : Neocles Leontis |
Publisher | : Springer Science & Business Media |
Total Pages | : 402 |
Release | : 2012-06-05 |
Genre | : Science |
ISBN | : 3642257402 |
Download RNA 3D Structure Analysis and Prediction Book in PDF, ePub and Kindle
With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.
Author | : |
Publisher | : |
Total Pages | : 352 |
Release | : 1986-10-31 |
Genre | : |
ISBN | : 9781468451740 |
Download Structure and Dynamics of RNA Book in PDF, ePub and Kindle
Author | : P. H. van Knippenberg |
Publisher | : Springer Science & Business Media |
Total Pages | : 335 |
Release | : 2013-03-08 |
Genre | : Technology & Engineering |
ISBN | : 1468451731 |
Download Structure and Dynamics of RNA Book in PDF, ePub and Kindle
This volume contains contributions from the speakers at the NATO Advanced Research Workshop on "3D 5tructure and Dynamics of RNA", which was held in Renesse, The Netherlands, 21 - 24 August, 1985. Two major developments have determined the progress of nucleic acid research during the last decade. First, manipulation of genetic material by recombinant DNA methodology has enabled detailed studies of the function of nucleic acids in vivo. 5econd, the use of powerful physical methods, such as X-ray diffraction and nuclear magnetic resonance spectroscopy, in the study of biomacromolecules has provided information regarding the structure and the dynamics of nucleic acids. Both developments were enabled by the advance of synthetic methods that allow preparation of nucleic acid molecules of required sequence and length. The basic understanding of nucleic acid function will ultimately depend on a close collaboration between molecular biologists and biophy sicists. In the case of RNA, the ground rules for the formation of secondary structure have been derived from physical studies of oligoribonucleotides. Powerfull spectroscopic techniques have revealed more details of ~~A structure including novel conformations (e.g. left-handed Z-RNA). A wealth of information has been obtained by studying the relatively small transfer RNA molecules. A few of these RNAs have been crystallized, enabling determination of their three-dimensional structure. It has become apparent that "non-classical" basepairing between distal nucleotides gives rise to tertiary interactions, determining the overall shape of the molecule.
Author | : Martijn Adriaan Huynen |
Publisher | : |
Total Pages | : 105 |
Release | : 1993 |
Genre | : |
ISBN | : 9789039301586 |
Download Evolutionary dynamics and pattern generation in the sequence and secondary structure of RNA Book in PDF, ePub and Kindle
Author | : Ronny Lorenz |
Publisher | : Springer Nature |
Total Pages | : 407 |
Release | : |
Genre | : |
ISBN | : 1071635190 |
Download RNA Folding Book in PDF, ePub and Kindle
Author | : Marina V. Rodnina |
Publisher | : Springer Science & Business Media |
Total Pages | : 428 |
Release | : 2011-12-10 |
Genre | : Medical |
ISBN | : 3709102154 |
Download Ribosomes Structure, Function, and Dynamics Book in PDF, ePub and Kindle
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
Author | : Philippe Jeanteur |
Publisher | : Springer |
Total Pages | : 161 |
Release | : 2007-11-03 |
Genre | : Science |
ISBN | : 3540742662 |
Download RNA Trafficking and Nuclear Structure Dynamics Book in PDF, ePub and Kindle
This volume explores nuclear structure and trafficking involving or relevant to RNA and RNPs. Topics include advances and current problems in the structural organization of different subnuclear compartments, Cajal bodies and gems, speckles containing splicing factors, and PML bodies characteristic of ProMyelocytic leukemia. The book also describes the dynamic aspects of RNA trafficking and the latest technologies for live cell imaging of mRNA.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 186 |
Release | : 1987-02-01 |
Genre | : Computers |
ISBN | : 0309062284 |
Download Computer Assisted Modeling Book in PDF, ePub and Kindle
In much of biology, the search for understanding the relation between structure and function is now taking place at the macromolecular level. Proteins, nucleic acids, and polysaccharides are macromolecule--polymers formed from families of simpler subunits. Because of their size and complexity, the polymers are capable of both inter- and intramolecular interactions. These interactions confer upon the polymers distinctive three-dimensional shapes. These tertiary configurations, in turn, determine the function of the macromolecule. Computers have become so inextricably involved in empirical studies of three-dimensional macromolecular structure that mathematical modeling, or theory, and experimental approaches are interrelated aspects of a single enterprise.