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| Author | : Lawrence C. Kuo |
| Publisher | : Gulf Professional Publishing |
| Total Pages | : 494 |
| Release | : 1994-09-22 |
| Genre | : Medical |
| ISBN | : 9780121821425 |
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
| Author | : Laurence H. Pearl |
| Publisher | : |
| Total Pages | : 200 |
| Release | : 1990 |
| Genre | : Endopeptidases |
| ISBN | : |
This volume describes the state-of-the-art of our understanding of the structure and function of retroviral proteases, and their substrates, the viral polyproteins, described by the leading workers in the field.
| Author | : Vladimír Kostka |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 220 |
| Release | : 2019-07-22 |
| Genre | : Science |
| ISBN | : 3110862786 |
No detailed description available for "Proteases of Retroviruses".
| Author | : Satya Prakash Gupta |
| Publisher | : Academic Press |
| Total Pages | : 516 |
| Release | : 2017-07-03 |
| Genre | : Science |
| ISBN | : 0128096829 |
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases
| Author | : Hans-Georg Kräusslich |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 354 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642801455 |
Retroviruses arguably belong to the most fascinating of all viruses because of their unusual and highly efficient mode of replication involving reverse transcription and integration of the viral genome and a complex system of transcriptional and post transcriptional regulatory mechanisms. The importance of ret roviruses as human and animal pathogens has also enhanced scientific and medical interest in this diverse group of viruses and has spurred an intensive search for novel and improved antiviral agents. More recently, analysis of retroviral replication and in particular understanding the formation and composition of the virus particle has received additional attention because of the promise of retroviral vectors as vehicles for human somatic gene therapy. Many recent advances have been made in our understanding of the molecular mechanisms governing as sembly and release of infectious retrovirus particles. This book attempts to summarize these recent developments and to provide an overview of our current knowledge on retrovirus particle formation. The individual chapters of the book deal with specific steps in the pathway of retroviral morphogenesis and maturation, starting at the time when the components of the virus have been synthesized within the infected cell and ending once the infectious virion has been released from the cell. An introductory chapter provides a comparative description of the structure and morphology of various retroviruses.
| Author | : Alan J. Barrett |
| Publisher | : Elsevier |
| Total Pages | : 1182 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0080984150 |
Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.
| Author | : Uwe Lendeckel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 139 |
| Release | : 2009-06-19 |
| Genre | : Medical |
| ISBN | : 9048123488 |
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 459 |
| Release | : 1991-01-28 |
| Genre | : Technology & Engineering |
| ISBN | : 9780080865966 |
The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.
| Author | : Matthias Gotte |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2018-02-12 |
| Genre | : Medical |
| ISBN | : 9781493906932 |
While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
| Author | : Klaus, von der Helm |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 427 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642570925 |
With contributions by numerous experts
