Retinoids In Mammalian Reproduction With An Initial Scoping Effort To Identify Regulatory Methods PDF Download
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Author | : Nilsson, Charlotte |
Publisher | : Nordic Council of Ministers |
Total Pages | : 116 |
Release | : 2020-04-19 |
Genre | : Political Science |
ISBN | : 9289365307 |
Download Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods Book in PDF, ePub and Kindle
Available online: https://pub.norden.org/temanord2020-507/ Abstract [en] This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.
Author | : Eleanor Chelimsky |
Publisher | : DIANE Publishing |
Total Pages | : 118 |
Release | : 2000 |
Genre | : |
ISBN | : 9780788186264 |
Download Reproductive and Developmental Toxicants Book in PDF, ePub and Kindle
Evaluates federal regulatory actions on environmental chemicals known to cause adverse reproductive and developmental outcomes. Identifies 30 environmental chemicals found to be of high concern because of the widespread acknowledgment of their reproductive and developmental consequences as toxicants. Determines the extent to which these chemicals are regulated by the federal government. Assesses the degree to which these regulatory actions are based on reproductive and developmental toxicity. Evaluates whether the regulatory protection currently provided to the public against reproductive and developmental disease is sufficient.
Author | : H. DeLuca |
Publisher | : Springer Science & Business Media |
Total Pages | : 297 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461588707 |
Download The Fat-Soluble Vitamins Book in PDF, ePub and Kindle
The first demonstration of the existence of a vitamin and the full recognition of this fact are often attributed to the work of McCollum, who found that a sub stance in butterfat and cod-liver oil was necessary for growth and health of ani mals fed purified diets. It became obvious that an organic substance present in microconcentrations was vital to growth and reproduction of animals. Following the coining of the word vitamine by Funk, McCollum named this fat-soluble sub stance vitamin A. We can, therefore, state that vitamin A was certainly one of the first known vitamins, yet its function and the function of the other fat-soluble vitamins had remained largely unknown until recent years. However, there has been an explosion of investigation and new information in this field, which had remained quiescent for at least two or three decades. It is now obvious that the fat-soluble vitamins function quite differently from their water-soluble counter parts. We have learned that vitamin D functions by virtue of its being converted in the kidney to a hormone that functions to regulate calcium and phosphorus metabolism. This new endocrine system is in the process of being elucidated in detail, and in addition, the medical use of these hormonal forms of vitamin D in the treatment of a variety of metabolic bone diseases has excited the medical com munity.
Author | : Kevin Coward |
Publisher | : Cambridge University Press |
Total Pages | : 408 |
Release | : 2013-10-31 |
Genre | : Medical |
ISBN | : 110727625X |
Download Textbook of Clinical Embryology Book in PDF, ePub and Kindle
The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 348 |
Release | : 2000-12-21 |
Genre | : Nature |
ISBN | : 0309070864 |
Download Scientific Frontiers in Developmental Toxicology and Risk Assessment Book in PDF, ePub and Kindle
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author | : Arnold van Huis |
Publisher | : Bright Sparks |
Total Pages | : 0 |
Release | : 2013 |
Genre | : Conservation of natural resources |
ISBN | : 9789251075951 |
Download Edible Insects Book in PDF, ePub and Kindle
Edible insects have always been a part of human diets, but in some societies there remains a degree of disdain and disgust for their consumption. Although the majority of consumed insects are gathered in forest habitats, mass-rearing systems are being developed in many countries. Insects offer a significant opportunity to merge traditional knowledge and modern science to improve human food security worldwide. This publication describes the contribution of insects to food security and examines future prospects for raising insects at a commercial scale to improve food and feed production, diversify diets, and support livelihoods in both developing and developed countries. It shows the many traditional and potential new uses of insects for direct human consumption and the opportunities for and constraints to farming them for food and feed. It examines the body of research on issues such as insect nutrition and food safety, the use of insects as animal feed, and the processing and preservation of insects and their products. It highlights the need to develop a regulatory framework to govern the use of insects for food security. And it presents case studies and examples from around the world. Edible insects are a promising alternative to the conventional production of meat, either for direct human consumption or for indirect use as feedstock. To fully realise this potential, much work needs to be done by a wide range of stakeholders. This publication will boost awareness of the many valuable roles that insects play in sustaining nature and human life, and it will stimulate debate on the expansion of the use of insects as food and feed.
Author | : |
Publisher | : |
Total Pages | : 32 |
Release | : 2000 |
Genre | : Dental public health |
ISBN | : |
Download Oral Health in America Book in PDF, ePub and Kindle
Author | : C. Bartsch |
Publisher | : Springer Science & Business Media |
Total Pages | : 979 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 364259512X |
Download The Pineal Gland and Cancer Book in PDF, ePub and Kindle
The link between the pineal gland and cancer is a rapidly emerging research field due to promising experimental and clinical trials with melatonin. The pineal gland acts as a transducer of environmental light to regulate rhythmic processes, including reproductive function in seasonally breeding animals and the entrainment of circadian rhythms, such as the sleep-wake cycle, in man. This book elucidates the physiological significance of the pineal gland and surveys phenomena and mechanisms of pineal - tumor interaction at the neuroendocrine, neuroimmune, neural, and molecular levels. Yet unidentified low-molecular-weight pineal substances with tumor-inhibiting capacity, a possible involvement of melatonin in electromagnetic field effects on cancer, and the oncotherapeutic potential of melatonin are also addressed. The encouraging results should incite further research to elucidate the exact nature of the link between the pineal gland and cancer for the benefit of patients.
Author | : European Commission. Scientific Committee on Food |
Publisher | : |
Total Pages | : 478 |
Release | : 2006 |
Genre | : Dietary supplements |
ISBN | : 9789291990146 |
Download Tolerable upper intake levels for vitamins and minerals Book in PDF, ePub and Kindle
Author | : |
Publisher | : Academic Press |
Total Pages | : 612 |
Release | : 2020-04-29 |
Genre | : Science |
ISBN | : 0128201479 |
Download Retinoid Signaling Pathways Book in PDF, ePub and Kindle
Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways