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Drug Repositioning

Drug Repositioning
Author: Michael J. Barratt
Publisher: John Wiley & Sons
Total Pages: 499
Release: 2012-05-29
Genre: Medical
ISBN: 0470878274
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The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

Drug Repositioning

Drug Repositioning
Author: Michael J. Barratt
Publisher: John Wiley & Sons
Total Pages: 499
Release: 2012-04-11
Genre: Medical
ISBN: 1118274393
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Download Drug Repositioning Book in PDF, ePub and Kindle

The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

Drug Repositioning

Drug Repositioning
Author: Joel Dudley
Publisher: CRC Press
Total Pages: 331
Release: 2017-07-14
Genre: Medical
ISBN: 1482220849
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Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

Summary: Repositioning

Summary: Repositioning
Author: BusinessNews Publishing,
Publisher: Primento
Total Pages: 45
Release: 2014-11-12
Genre: Business & Economics
ISBN: 2511021382
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The must-read summary of Jack Trout and Steve Rivkin's book: "Repositioning: Marketing in an Era of Competition, Change and Crisis". This complete summary of the ideas from Jack Trout and Steve Rivkin's book "Repositioning" shows how positioning is all about how you differentiate yourself in the mind of prospective customers – the process of creating mental links so whenever people think about your product category or line of business, your company’s name will spring to mind. Repositioning is all about how you adjust and fine-tune perceptions about your company or your competition in order to make your marketing strategy work. In their book, the authors explain that you need to constantly keep repositioning, or you will be left behind. This summary provides readers with the solution to staying on top of their industries in this era of rapid technological change. Added-value of this summary: • Save time • Understand key concepts • Expand your knowledge To learn more, read "Repositioning" and find out what you can do to face today's market and succeed.

Repositioning Organization Theory

Repositioning Organization Theory
Author: S. Böhm
Publisher: Springer
Total Pages: 241
Release: 2005-11-08
Genre: Business & Economics
ISBN: 0230501419
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Repositioning Organization Theory studies the political positioning of organization theory. The book argues that there are two main projects in organization theory: the hegemonic project of positioning and postmodern project of depositioning. To critique the theoretical and political limits of these two projects, Böhm employs a range of critical and post-structural philosophies. Having conceptualized the need for a 'political event', the book is a passionate call for repositioning and repoliticizing organization theory. This book discusses the impossibilities of, and strategies for, such a project.

Optimizing Liner Shipping Fleet Repositioning Plans

Optimizing Liner Shipping Fleet Repositioning Plans
Author: Kevin Tierney
Publisher: Springer
Total Pages: 188
Release: 2015-06-16
Genre: Business & Economics
ISBN: 331917665X
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This monograph addresses several critical problems to the operations of shipping lines and ports, and provides algorithms and mathematical models for use by shipping lines and port authorities for decision support. One of these problems is the repositioning of container ships in a liner shipping network in order to adjust the network to seasonal shifts in demand or changes in the world economy. We provide the first problem description and mathematical model of repositioning and define the liner shipping fleet repositioning problem (LSFRP). The LSFRP is characterized by chains of interacting activities with a multi-commodity flow over paths defined by the activities chosen. We first model the problem without cargo flows with a variety of well-known optimization techniques, as well as using a novel method called linear temporal optimization planning that combines linear programming with partial-order planning in a branch-and-bound framework. We then model the LSFRP with cargo flows, using several different mathematical models as well as two heuristic approaches. We evaluate our techniques on a real-world dataset that includes a scenario from our industrial collaborator. We show that our approaches scale to the size of problems faced by industry, and are also able to improve the profit on the reference scenario by over US$14 million.

Modelling Empty Container Repositioning Logistics

Modelling Empty Container Repositioning Logistics
Author: Dong-Ping Song
Publisher: Springer Nature
Total Pages: 174
Release: 2022-01-20
Genre: Business & Economics
ISBN: 3030933830
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The book takes the inventory control perspective to tackle empty container repositioning logistics problems in regional transportation systems by explicitly considering the features such as demand imbalance over space, dynamic operations over time, uncertainty in demand and transport, and container leasing phenomenon. The book has the following unique features. First, it provides a discussion of broad empty equipment logistics including empty freight vehicle redistribution, empty passenger vehicle redistribution, empty bike repositioning, empty container chassis repositioning, and empty container repositioning (ECR) problems. The similarity and unique characteristics of ECR compared to other empty equipment repositioning problems are explained. Second, we adopt the stochastic dynamic programming approach to tackle the ECR problems, which offers an algorithmic strategy to characterize the optimal policy and captures the sequential decision-making phenomenon in anticipation of uncertainties over time and space. Third, we are able to establish closed-form solutions and structural properties of the optimal ECR policies in relatively simple transportation systems. Such properties can then be utilized to construct threshold-type ECR policies for more complicated transportation systems. In fact, the threshold-type ECR policies resemble the well-known (s, S) and (s, Q) policies in inventory control theory. These policies have the advantages of being decentralized, easy to understand, easy to operate, quick response to random events, and minimal on-line computation and communication. Fourth, several sophisticated optimization techniques such as approximate dynamic programming, simulation-based meta-heuristics, stochastic approximation, perturbation analysis, and ordinal optimization methods are introduced to solve the complex stochastic optimization problems. The book will be of interest to researchers and professionals in logistics, transport, supply chain, and operations research.

The Global Repositioning of Japanese Religions

The Global Repositioning of Japanese Religions
Author: Ugo Dessi
Publisher: Routledge
Total Pages: 384
Release: 2016-07-01
Genre: Social Science
ISBN: 1317030125
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The Global Repositioning of Japanese Religions: An Integrated Approach explores how Japanese religions respond to the relativizing effects of globalization, thereby repositioning themselves as global players. Organized around concrete case studies focusing on the engagement of Japanese Buddhism, Shinto, and several new religious movements in areas such as ecology, inter-religious dialogue, and politics, this book shows that the globalization of Japanese religions cannot be explained simply in terms of worldwide institutional expansion. Rather, it is a complex phenomenon conditioned by a set of pervasive factors: changes in consciousness, the perception of affinities and resonances at the systemic and cultural levels, processes of decontextualization, and a wide range of power issues including the re-enactment of cultural chauvinism. The author investigates these dynamics systematically with attention to broader theoretical questions, cross-cultural similarities, the definition of religion and the perils of ethnocentrism, in order to develop his Global Repositioning model, which constitutes an integrated approach to the study of Japanese religions under globalization. An empirically-grounded and theoretically-informed study of the effects of global trends on local religions, this book will appeal to scholars and students with interests in globalization, religious studies, Japanese studies, Hawaii, sociology, anthropology, and ecology.

The Strategic Repositioning of Arts, Culture and Heritage in the 21st Century

The Strategic Repositioning of Arts, Culture and Heritage in the 21st Century
Author: George Mugovhani
Publisher: Cambridge Scholars Publishing
Total Pages: 323
Release: 2018-06-11
Genre: Art
ISBN: 1527512916
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The post-millennium world has been experiencing several recognisable historical milestones with regard to arts, culture and heritage. One of these has been the resuscitation and revival of creative elements of the arts, culture and heritage of previously marginalised or disadvantaged communities around the world. Until recently, there had been scant regard and skewed allocation of resources for these, but lately attempts have been made to promote and sustain them in order to enable the socio-economic aspirations of a multicultural society. The contributions brought together here are the product of papers that were presented during a conference on “Strategic Repositioning of Arts, Culture and Heritage in the 21st Century”. They cover a broad spectrum of subjects such as indigeneity, music, song and identity, politics, national reconciliation, education, product development, and national development.

Drug Repositioning: Current Advances and Future Perspectives

Drug Repositioning: Current Advances and Future Perspectives
Author: Yuhei Nishimura
Publisher: Frontiers Media SA
Total Pages: 153
Release: 2019-01-11
Genre:
ISBN: 288945696X
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Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.