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| Author | : Brad Allen Pendell |
| Publisher | : |
| Total Pages | : 92 |
| Release | : 1998 |
| Genre | : |
| ISBN | : |
| Author | : Slobodan Vukicevic |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 349 |
| Release | : 2008-08-15 |
| Genre | : Science |
| ISBN | : 3764385529 |
Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). Chapters are dedicated to the regulation of BMP-signaling pathways; biological actions of BMPs in bone, cartilage, and teeth; clinical applications; and the potential systemic use of BMPs for tissues beyond bone. The authors are all recognized experts in the field of tissue engineering and regeneration.
| Author | : Slobodan Vukicevic |
| Publisher | : Springer |
| Total Pages | : 320 |
| Release | : 2012-11-28 |
| Genre | : Science |
| ISBN | : 3034878575 |
Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica cy of BMPs in almost all crucial developmental events as well as during regenera tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.
| Author | : Slobodan Vukicevic |
| Publisher | : Springer |
| Total Pages | : 335 |
| Release | : 2012-11-28 |
| Genre | : Science |
| ISBN | : 3034881215 |
From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions. This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.
| Author | : Slobodan Vukicevic |
| Publisher | : Springer |
| Total Pages | : 448 |
| Release | : 2017-03-14 |
| Genre | : Medical |
| ISBN | : 331947507X |
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
| Author | : Melissa Helen Little |
| Publisher | : Academic Press |
| Total Pages | : 615 |
| Release | : 2015-08-06 |
| Genre | : Science |
| ISBN | : 012800438X |
Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
| Author | : |
| Publisher | : ScholarlyEditions |
| Total Pages | : 94 |
| Release | : 2012-01-09 |
| Genre | : Medical |
| ISBN | : 1464932417 |
Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Morphogenetic Proteins in a concise format. The editors have built Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
| Author | : Jamie A. Davies |
| Publisher | : Academic Press |
| Total Pages | : 286 |
| Release | : 2018-03-09 |
| Genre | : Science |
| ISBN | : 012812637X |
Organs and Mini-Organs combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved. Collects the best protocols of organoid cultures from diverse tissues Covers a wide range of organs Includes troubleshooting cases for common, but specific problems for each culture conditions Provides an entire section on the application of organoids
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 367 |
| Release | : 2015-08-12 |
| Genre | : Medical |
| ISBN | : 0128025921 |
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on Bone Morphogenic Protein. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels
| Author | : Irving M. Shapiro |
| Publisher | : IOS Press |
| Total Pages | : 312 |
| Release | : 2002 |
| Genre | : Computers |
| ISBN | : 9781586032401 |
Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
