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Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
Author: Daniel Laskowitz
Publisher: CRC Press
Total Pages: 388
Release: 2016-04-21
Genre: Medical
ISBN: 1498766579

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Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme


Cerebral Blood Flow in Acute Head Injury

Cerebral Blood Flow in Acute Head Injury
Author: Georg E. Cold
Publisher: Springer Science & Business Media
Total Pages: 74
Release: 2012-12-06
Genre: Medical
ISBN: 3709191017

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During the last decade a multitude of studies concerning the dynamic changes in cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and intracranial pressure (ICP) in the acute phase after head injury have been published. These studies have been supplemented with studies of cerebral autoregulation, CO2 reactivity and barbiturate reactivity. Other investigations include studies of cerebrospinal fluid pH, bicarbonate, lactate and pyruvate. In this book experimental and clinical studies of the dynamic changes in CBF, CMRO2, CO2 reactivity and barbiturate reactivity are reviewed. The author's own clinical studies of the dynamic changes in CBF and cerebral metabolism are summarized and discussed, and the therapeutical implication as regards the use of artificial hyperventilation, sedation with barbiturate and mannitol treatment are discussed.


Neuroimaging of Traumatic Brain Injury

Neuroimaging of Traumatic Brain Injury
Author: Natalia Zakharova
Publisher: Springer
Total Pages: 170
Release: 2014-07-08
Genre: Medical
ISBN: 3319043552

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The main purpose of this book is to present emerging neuroimaging data in order to define the role of primary and secondary structural and hemodynamic disturbances in different phases of traumatic brain injury (TBI) and to analyze the potential of diffusion tensor MRI, tractography and CT perfusion imaging in evaluating the dynamics of TBI. The authors present a new MRI classification of brain stem and hemispheric cortical/subcortical damage localization that is of significant prognostic value. New data are provided regarding the pathogenesis and dynamics of diffuse and focal brain injuries and qualitative and quantitative changes in the brain white matter tracts. It is shown that diffuse axonal injury can be considered a clinical model of multidimensional “split brain” with commissural, association and projection fiber disorders. The book will be of interest for neuroradiologists, neurosurgeons, neurologists and others with an interest in the subject.


Kids, Sports, and Concussion

Kids, Sports, and Concussion
Author: William Paul Meehan III
Publisher: Bloomsbury Publishing USA
Total Pages: 210
Release: 2018-02-08
Genre: Psychology
ISBN:

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A comprehensive summary of sport-related concussion for parents, coaches, and athletes that considers the physics behind the injury, identifies what can be done to reduce the risk of its occurrence, and describes how to respond to a suspected concussion. Concussion injury among athletes continues to be a subject of great concern. Increasing attention and research is focusing on the most vulnerable of athletes—children. What strategies can be taken to best protect young athletes in sports from grammar school football leagues to high school hockey and soccer teams from concussion? How do we treat youngsters who suffer head injuries in sports? What are the ethical considerations in allowing children to play such sports, given the risks to still-developing brains? In this updated and expanded guide, William Meehan, MD, explains simply and clearly how coaches, parents, and others who work with young athletes can recognize concussion; best help children and youths recover from concussion injuries; and take steps to become proactive to prevent concussion. Readers will learn what causes a sport-related concussion; what happens to brain cells during a concussion; and why concussion, which in the past was dismissed as a trivial injury, is taken so much more seriously now. The book explains how to decrease the risk of concussion; addresses the potential for cumulative effects from multiple concussions, including chronic traumatic encephalopathy; and discusses the ethical dimensions of deciding whether an athlete with multiple concussions should continue to participate in high-risk sports.


Nutrition and Traumatic Brain Injury

Nutrition and Traumatic Brain Injury
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 444
Release: 2011-07-01
Genre: Medical
ISBN: 0309210089

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Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.


Vascular Mechanisms in CNS Trauma

Vascular Mechanisms in CNS Trauma
Author: Eng H. Lo
Publisher: Springer Science & Business Media
Total Pages: 523
Release: 2013-11-04
Genre: Medical
ISBN: 1461486904

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While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.​


Cerebral Blood Flow, Metabolism, and Head Trauma

Cerebral Blood Flow, Metabolism, and Head Trauma
Author: Christian W. Kreipke
Publisher: Springer Science & Business Media
Total Pages: 174
Release: 2012-08-07
Genre: Medical
ISBN: 146144148X

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Written to satisfy a wide audience, from basic scientist to clinical researcher, this volume explores such varied concepts as: the influence of CBF in the pathotrajectory of TBI, modeling TBI as a means to understand underlying pathological states associated with brain injury victims, disrupted vasculature following head trauma and advanced imaging techniques, vasoreactive substances underlying disrupted blood flow, the role of age and sex on injury outcome, and the latest pre-clinical rationale for focusing on CBF and strategies to improve blood flow as a means to improve outcome in patients suffering the effects of TBI.


Neurocritical Care

Neurocritical Care
Author: Werner Hacke
Publisher: Springer Science & Business Media
Total Pages: 1052
Release: 2012-12-06
Genre: Medical
ISBN: 3642876021

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A Quick Reference Text! Easy to read and practical in design, Neurocritical Care is the book specialists will turn to for quick reference. It concentrates on management problems, from diagnostic procedures to therapeutic strategies. Exact descriptions are given for treatment procedures, and it is easy to find the appropriate treatment for a given patient. International Expertise! More than 100 authors from North America have contributed to the book. The different strategies used on either side of the Atlantic have been described, the sections on neuroimaging have been reviewed by a neuroradiologist. Comprehensive in Scope! Both frequent and rare neurological diseases that may require critical care treatment and subjects of more general interest such as monitoring strategies, ethical problems, brain death and neurological disorders in internal medicine have been covered. Pathophysiology is also discussed, insomuch as it is important for understanding the treatment strategies.


Sports-Related Concussions in Youth

Sports-Related Concussions in Youth
Author: National Research Council
Publisher: National Academies Press
Total Pages: 215
Release: 2014-02-04
Genre: Medical
ISBN: 0309288037

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In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions - especially among youth. Despite growing awareness of sports-related concussions and campaigns to educate athletes, coaches, physicians, and parents of young athletes about concussion recognition and management, confusion and controversy persist in many areas. Currently, diagnosis is based primarily on the symptoms reported by the individual rather than on objective diagnostic markers, and there is little empirical evidence for the optimal degree and duration of physical rest needed to promote recovery or the best timing and approach for returning to full physical activity. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture reviews the science of sports-related concussions in youth from elementary school through young adulthood, as well as in military personnel and their dependents. This report recommends actions that can be taken by a range of audiences - including research funding agencies, legislatures, state and school superintendents and athletic directors, military organizations, and equipment manufacturers, as well as youth who participate in sports and their parents - to improve what is known about concussions and to reduce their occurrence. Sports-Related Concussions in Youth finds that while some studies provide useful information, much remains unknown about the extent of concussions in youth; how to diagnose, manage, and prevent concussions; and the short- and long-term consequences of concussions as well as repetitive head impacts that do not result in concussion symptoms. The culture of sports negatively influences athletes' self-reporting of concussion symptoms and their adherence to return-to-play guidance. Athletes, their teammates, and, in some cases, coaches and parents may not fully appreciate the health threats posed by concussions. Similarly, military recruits are immersed in a culture that includes devotion to duty and service before self, and the critical nature of concussions may often go unheeded. According to Sports-Related Concussions in Youth, if the youth sports community can adopt the belief that concussions are serious injuries and emphasize care for players with concussions until they are fully recovered, then the culture in which these athletes perform and compete will become much safer. Improving understanding of the extent, causes, effects, and prevention of sports-related concussions is vitally important for the health and well-being of youth athletes. The findings and recommendations in this report set a direction for research to reach this goal.