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| Author | : Matthew M. Binns |
| Publisher | : CRC Press |
| Total Pages | : 360 |
| Release | : 1992-05-27 |
| Genre | : Science |
| ISBN | : 9780849361791 |
Download Recombinant Poxviruses Book in PDF, ePub and Kindle
Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
| Author | : Stuart N. Isaacs |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 402 |
| Release | : 2008-02-03 |
| Genre | : Science |
| ISBN | : 1592597890 |
Download Vaccinia Virus and Poxvirology Book in PDF, ePub and Kindle
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
| Author | : Richard W. Moyer |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 220 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642756050 |
Download Poxviruses Book in PDF, ePub and Kindle
The purpose of this volume is to highlight some current areas of poxvirus research which are likely to be particularly fruitful in the upcoming few years. The first chapter, by Drs. Condit and Niles, discusses poxvirus genetics. Work in this area has provided mutants, produced practical procedures to simplify the manipulation of viral genes, and generated information about the molecular architecture and organization of genes characteristic of pox viruses. One of the most intensively studied regions of the viral genome is the HindIII D region of vaccinia, in which a combination of classical and molecular genetic analysis of the region has been particularly revealing. Within this region are open reading frames, some of which are expressed early and others late, organized in a fashion which is now known to be typical of these viruses. Other studies, related to temperature sensitive, drug resistant, and drug dependent mutants, are also discussed. Each of the other reviews included in this volume summarizes areas of research which have depended heavily on the genetics of the system. The intracellular site of a poxvirus infection is mostly, if not exclusively, limited to the cytoplasm which dictates several interesting biological ramifications. For example, poxvirus transcription must occur in the cytoplasm, rather than in the nucleus. The virus copes with this situation by incorporating into the virion the enzymatic machinery necessary to initiate transcription from input virus.
| Author | : Samuel Dales |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 202 |
| Release | : 2013-03-08 |
| Genre | : Medical |
| ISBN | : 3709186250 |
Download Biology of Poxviruses Book in PDF, ePub and Kindle
This volume, Biology of Poxviruses, marks our debut as editors of this well known series. We plan to continue the tradition of providing a forum for exten sive, critical reviews of individual virus groups, as exemplified by the present volume. But the pace of discovery is accelerating so rapidly that we feel the need to offer an additional format: volumes that contain collections of shorter, topical reviews on a group of related subjects. Such collections might cut across con ventional boundaries between virus groups, dealing, as an example, with a partic ular aspect of virus-cell interaction. Admittedly, this new format stretches the term "monograph" beyond the accepted definition, but we believe that we should pay that price to maintain the usefulness of the series as a medium of scientific communication. Whenever possible, we will enlist the aid of deputy editors to bring such col lections to fruition. As in the past, the editors and the publisher will welcome suggestions for topics and contributions.
| Author | : Christopher Kulova Ngichabe |
| Publisher | : |
| Total Pages | : 346 |
| Release | : 1992 |
| Genre | : |
| ISBN | : |
Download Recombinant Raccoon Poxvirus-vectored Feline Vaccines Book in PDF, ePub and Kindle
| Author | : Andrew Mercer |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 447 |
| Release | : 2007-02-15 |
| Genre | : Medical |
| ISBN | : 3764375574 |
Download Poxviruses Book in PDF, ePub and Kindle
This monograph provides a comprehensive review of the poxvirus family with a particular emphasis on current developments. It includes the latest insights into poxviral molecular biology, diagnosis, therapy, vaccine development and the beneficial exploitation of these viruses in biomedical research. Each chapter is written by a leader in the field, and the book includes historical perspectives and summaries of recent advances in the field.
| Author | : Elizabeth Gertruida Brand |
| Publisher | : |
| Total Pages | : |
| Release | : 1993 |
| Genre | : |
| ISBN | : |
Download Selectable markers for recombinant poxviruses Book in PDF, ePub and Kindle
| Author | : Liangbiao Hu |
| Publisher | : |
| Total Pages | : 366 |
| Release | : 1995 |
| Genre | : |
| ISBN | : |
Download Development of Raccoon Poxvirus Vectored Feline Recombinant Vaccines Book in PDF, ePub and Kindle
| Author | : Kelly K. Hunt |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 469 |
| Release | : 2007-10-26 |
| Genre | : Medical |
| ISBN | : 159745222X |
Download Gene Therapy for Cancer Book in PDF, ePub and Kindle
The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
| Author | : Committee on the Assessment of Future Scientific Needs for Variola Virus |
| Publisher | : National Academies Press |
| Total Pages | : 126 |
| Release | : 1999-05-14 |
| Genre | : Medical |
| ISBN | : 030959698X |
Download Assessment of Future Scientific Needs for Live Variola Virus Book in PDF, ePub and Kindle
In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.
