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Author | : Ota Fuchs |
Publisher | : BoD – Books on Demand |
Total Pages | : 122 |
Release | : 2019-02-20 |
Genre | : Medical |
ISBN | : 1789854776 |
Download Recent Developments in Myelodysplastic Syndromes Book in PDF, ePub and Kindle
This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.
Author | : Ota Fuchs |
Publisher | : |
Total Pages | : 120 |
Release | : 2019 |
Genre | : Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
ISBN | : 9781789854787 |
Download Recent Developments in Myelodysplastic Syndromes Book in PDF, ePub and Kindle
This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.
Author | : Uwe Platzbecker |
Publisher | : Springer |
Total Pages | : 157 |
Release | : 2018-06-05 |
Genre | : Medical |
ISBN | : 3319768794 |
Download Myelodysplastic Syndromes Book in PDF, ePub and Kindle
This book reviews the standard diagnostic and therapeutic management of patients with myelodysplastic syndromes (MDS) and examines ongoing research developments in the field. The importance of appropriate prognostic stratification, taking into account recent advances in understanding of the molecular pathogenesis of MDS, is explained, and both established and novel treatment approaches are discussed in depth. The coverage includes, for example, the use of erythropoietic stimulating agents, iron chelation therapy, the immunomodulator lenalidomide, hypomethylating agents such as azacitidine, and allogeneic hematopoietic stem cell transplantation. Myelodysplastic syndromes are heterogeneous and complex hematologic disorders ranging from indolent conditions to forms approaching the aggressiveness of acute myeloid leukemia. The diversity of MDS gives rise to challenges in diagnosis and clinical decision making, and the highly variable clinical course necessitates a risk-adapted treatment strategy and the application of disease-specific therapies. Hematologists, oncologists, and other interested clinicians will find this book to be an invaluable source of information on diagnostic and prognostic evaluation and treatment selection.
Author | : |
Publisher | : ScholarlyEditions |
Total Pages | : 92 |
Release | : 2012-01-09 |
Genre | : Medical |
ISBN | : 1464904006 |
Download Myelodysplastic Syndromes: New Insights for the Healthcare Professional: 2011 Edition Book in PDF, ePub and Kindle
Myelodysplastic Syndromes: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Myelodysplastic Syndromes in a concise format. The editors have built Myelodysplastic Syndromes: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Myelodysplastic Syndromes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Myelodysplastic Syndromes: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author | : M. Extermann |
Publisher | : Karger Medical and Scientific Publishers |
Total Pages | : 179 |
Release | : 2013-01-18 |
Genre | : Medical |
ISBN | : 3318023078 |
Download Cancer and Aging Book in PDF, ePub and Kindle
Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
Author | : Peter L. Greenberg |
Publisher | : Cambridge University Press |
Total Pages | : 344 |
Release | : 2011-02-17 |
Genre | : Medical |
ISBN | : 9781139447072 |
Download Myelodysplastic Syndromes Book in PDF, ePub and Kindle
Myelodysplastic Syndromes was first published in 2006, and continues to stand out as the definitive text on the genetics, pathophysiology, and clinical management of this wide range of syndromes. It remains a major reference on all aspects of the clinical classification underlying pathogenetic mechanisms and treatment of the myelodysplastic syndromes. Authored by international experts, the book provides an assessment of the subject's status and a variety of advances in the field. The chapters cover all aspects of the myelodysplastic syndromes, from an in-depth analysis of the multifactorial nature of this disease, including a careful assessment of stromal, immunological and stem cell abnormalities, to a review of recent molecular and cytogenetic discoveries and insights. This book will be a valuable resource to clinicians and researchers who wish to learn more about myelodysplastic syndromes.
Author | : Vinod Pullarkat |
Publisher | : Springer Nature |
Total Pages | : 200 |
Release | : 2021-10-09 |
Genre | : Medical |
ISBN | : 3030783111 |
Download Biology and Treatment of Leukemia and Bone Marrow Neoplasms Book in PDF, ePub and Kindle
This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Author | : Aziz Nazha |
Publisher | : Springer Nature |
Total Pages | : 179 |
Release | : 2020-08-13 |
Genre | : Medical |
ISBN | : 3030518787 |
Download Diagnosis and Management of Myelodysplastic Syndromes Book in PDF, ePub and Kindle
Myelodysplastic syndromes (MDS) are a group of clonal disorders characterized by pancytopenias and the risk of progression to acute myeloid leukemia. The diagnosis of MDS can be challenging, while the outcomes of MDS patients vary widely. This book provides a concise yet comprehensive overview of MDS. The book begins by reviewing the diagnostic workup of MDS, with a specific focus on the 2016 WHO criteria for MDS diagnosis, and the biology and pathophysiology of the disease. The text then presents the molecular landscape of MDS and its impact on disease diagnosis, prognosis, and treatment decisions. The book continues by profiling different prognostic models of MDS and concludes with a thorough review of treatment algorithms for lower and higher-risk MDS, as well as the use of hematopoietic stem cell transplant to combat the disease. Written by experts in the field, Diagnosis and Management of Myelodysplastic Syndromes: A Clinical Guide is a valuable resource for clinicians, practitioners, and researchers who are interested in MDS. The text also features over 100 illustrations, photographs, and tables.
Author | : John Bennett |
Publisher | : CRC Press |
Total Pages | : 556 |
Release | : 2002-05-21 |
Genre | : Medical |
ISBN | : 9780824707828 |
Download The Myelodysplastic Syndromes Book in PDF, ePub and Kindle
This reference provides a comprehensive overview of the latest research detailing the etiology, epidemiology, treatment, and detection of myelodysplastic syndromes (MDS)-identifying effective therapeutic regimens, adverse environmental and genetic factors, and efficient modalities of supportive care that improve patient survival and enhance quality of life. Contains recent amendments to MDS classification criteria by the World Health Organization! The Myelodysplastic Syndromes discusses immunological abnormalities and inflammatory diseases associated with MDS the development of therapy-related MDS auto and allo bone marrow transplantation the formation of apoptotic signals pharmacologic strategies for multidrug resistance in MDS patients the biological mechanisms of childhood MDS Presenting current guidelines to predict disease prognosis, The Myelodysplastic Syndromes is a detailed and timely guide for oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.
Author | : Ronald Hoffman |
Publisher | : |
Total Pages | : 2821 |
Release | : 2005 |
Genre | : Blood |
ISBN | : 9780443066283 |
Download Hematology Book in PDF, ePub and Kindle