Rat Jugular Vein And Carotid Artery Catheterization For Acute Survival Studies PDF Download
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| Author | : Angela Heiser |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 123 |
| Release | : 2007-06-01 |
| Genre | : Science |
| ISBN | : 0387494162 |
Download Rat Jugular Vein and Carotid Artery Catheterization for Acute Survival Studies Book in PDF, ePub and Kindle
Jugular vein and carotid artery cannulations are among the most widely used surgeries in research labs around the world. This book features two cannulation procedures detailed in a format of materials, instruction, and pictorial for each step. In addition, it also details procedures for anesthesia, pre- and post- operatives, anatomy, bleeding techniques using catheters implanted, and rat biodata compiled from numerous sources.
| Author | : Angela Heiser |
| Publisher | : Springer |
| Total Pages | : 116 |
| Release | : 2007-03-21 |
| Genre | : Science |
| ISBN | : 9780387494142 |
Download Rat Jugular Vein and Carotid Artery Catheterization for Acute Survival Studies Book in PDF, ePub and Kindle
Jugular vein and carotid artery cannulations are among the most widely used surgeries in research labs around the world. This book features two cannulation procedures detailed in a format of materials, instruction, and pictorial for each step. In addition, it also details procedures for anesthesia, pre- and post- operatives, anatomy, bleeding techniques using catheters implanted, and rat biodata compiled from numerous sources.
| Author | : Whitney Kayla Petrie |
| Publisher | : CRC Press |
| Total Pages | : 286 |
| Release | : 2015-03-24 |
| Genre | : Medical |
| ISBN | : 1040072518 |
Download The Care and Feeding of an IACUC Book in PDF, ePub and Kindle
Maintaining its user-friendly approach, this new edition of a bestseller summarizes information necessary for the effective and efficient operation of an IACUC. The book covers training programs and discusses professional certifications for IACUC administrative and animal care staff. It provides pointers to principal investigators, discusses interactions between IACUCs and other compliance panels, and addresses occupational health and safety programs and the role they play in the overall animal care and use program. It also delves deeply into bioethics to explore how IACUCs can ensure that each proposal to use animals in research includes an ethical review.
| Author | : Mark H. Tuszynski |
| Publisher | : Springer |
| Total Pages | : 584 |
| Release | : 2016-03-08 |
| Genre | : Medical |
| ISBN | : 148997654X |
Download Translational Neuroscience Book in PDF, ePub and Kindle
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.
| Author | : Xiaoling Li |
| Publisher | : John Wiley & Sons |
| Total Pages | : 875 |
| Release | : 2011-08-04 |
| Genre | : Medical |
| ISBN | : 1118067584 |
Download Oral Bioavailability Book in PDF, ePub and Kindle
Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches Caco-2 cell culture model, MDCK, and other related cell culture models which are used to study the science of oral bioavailability.
| Author | : Ming Hu |
| Publisher | : John Wiley & Sons |
| Total Pages | : 932 |
| Release | : 2024-01-09 |
| Genre | : Medical |
| ISBN | : 1119660688 |
Download Oral Bioavailability and Drug Delivery Book in PDF, ePub and Kindle
ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development. Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research. Oral Bioavailability and Drug Delivery readers will also find: Discussion questions in many chapters to facilitate comprehension Detailed discussion of topics including dissolution, absorption, metabolism, and more Real-world examples of methods in actions throughout Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.
| Author | : Mark Gray |
| Publisher | : Frontiers Media SA |
| Total Pages | : 161 |
| Release | : 2023-03-30 |
| Genre | : Medical |
| ISBN | : 2832519326 |
Download The use of large animal models to improve pre-clinical translational research Book in PDF, ePub and Kindle
| Author | : Andreas Pohlmann |
| Publisher | : Humana |
| Total Pages | : 725 |
| Release | : 2021-01-22 |
| Genre | : Science |
| ISBN | : 9781071609774 |
Download Preclinical MRI of the Kidney Book in PDF, ePub and Kindle
This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and improve the reproducibility of renal imaging research. Chapters provide guidance for exploring, using and developing small animal renal MRI in your laboratory as a unique tool for advanced in vivo phenotyping, diagnostic imaging, and research into potential new therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Preclinical MRI of the Kidney: Methods and Protocols is a valuable resource and will be of importance to anyone interested in the preclinical aspect of renal and cardiorenal diseases in the fields of physiology, nephrology, radiology, and cardiology. This publication is based upon work from COST Action PARENCHIMA, supported by European Cooperation in Science and Technology (COST). COST (www.cost.eu) is a funding agency for research and innovation networks. COST Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility and standardization of renal MRI biomarkers.
| Author | : Nancy L. Moureau |
| Publisher | : Springer |
| Total Pages | : 303 |
| Release | : 2019-06-10 |
| Genre | : Medical |
| ISBN | : 3030031497 |
Download Vessel Health and Preservation: The Right Approach for Vascular Access Book in PDF, ePub and Kindle
This Open access book offers updated and revised information on vessel health and preservation (VHP), a model concept first published in poster form in 2008 and in JVA in 2012, which has received a great deal of attention, especially in the US, UK and Australia. The book presents a model and a new way of thinking applied to vascular access and administration of intravenous treatment, and shows how establishing and maintaining a route of access to the bloodstream is essential for patients in acute care today. Until now, little thought has been given to an intentional process to guide selection, insertion and management of vascular access devices (VADs) and by default actions are based on crisis management when a quickly selected VAD fails. The book details how VHP establishes a framework or pathway model for each step of the patient experience, intentionally guiding, improving and eliminating risk when possible. The evidence points to the fact that reducing fragmentation, establishing a pathway, and teaching the process to all stakeholders reduces complications with intravenous therapy, improves efficiency and diminishes cost. As such this book appeals to bedside nurses, physicians and other health professionals.
| Author | : Hans Vogel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 2118 |
| Release | : 2007-10-30 |
| Genre | : Medical |
| ISBN | : 3540714200 |
Download Drug Discovery and Evaluation: Pharmacological Assays Book in PDF, ePub and Kindle
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
