Ras Family Gtpases PDF Download
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Author | : Channing Der |
Publisher | : Springer Science & Business Media |
Total Pages | : 403 |
Release | : 2007-04-29 |
Genre | : Medical |
ISBN | : 1402047088 |
Download RAS Family GTPases Book in PDF, ePub and Kindle
Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Author | : |
Publisher | : Elsevier |
Total Pages | : 824 |
Release | : 2006-06-07 |
Genre | : Science |
ISBN | : 0080463592 |
Download Regulators and Effectors of Small GTPases: Ras Family Book in PDF, ePub and Kindle
The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors. Since the last Methods in Enzymology volume on this topic in 2000, the study of Ras Family GTPases has witnessed a plethora of new directions and trends. With regards to the founding member of the Ras superfamily, the study of Ras in oncogenesis has seen the development and application of more advanced model cell culture and animal systems. The discovery of mutationally activated B-Raf in human cancers has injected renewed interest in this classical effector pathway of Ras. Includes a database for Ras family proteins and their effectors and regulators Complimentary to volume 406 coverage of the Rho family Over 150 international contributors
Author | : Alfred Wittinghofer |
Publisher | : Springer |
Total Pages | : 447 |
Release | : 2014-09-22 |
Genre | : Science |
ISBN | : 3709118069 |
Download Ras Superfamily Small G Proteins: Biology and Mechanisms 1 Book in PDF, ePub and Kindle
This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Author | : Ed Manser |
Publisher | : Springer Science & Business Media |
Total Pages | : 259 |
Release | : 2008-02-03 |
Genre | : Science |
ISBN | : 1592592813 |
Download GTPase Protocols Book in PDF, ePub and Kindle
In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a variety of novel te- niques and methodologies has been developed. These now enable investi- tors to move easily within a diversity of fields ranging from structural studies to real-time in vivo analysis of a GTPase. In recognition of the need for access to key background methodologies, GTPase Protocols: The Ras Superfamily is devoted to techniques that are pr- ently widely used and that will continue to be the standard for researchers worldwide. Each chapter is aimed at supplying detailed methodologies to allow reproduction in any laboratory, while also providing the general pr- ciples on which the methods are based. Some of the techniques grouped in the first section apply broadly to small GTPases, whereas others in Part II are more applicable within each GTPase subfamily.
Author | : |
Publisher | : Elsevier |
Total Pages | : 437 |
Release | : 2001-06-05 |
Genre | : Science |
ISBN | : 0080522564 |
Download Regulators and Effectors of Small GTPases, Part G: Ras Family II Book in PDF, ePub and Kindle
The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325, 329, and 332) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in the above-mentioned aspects of cell biology at the molecular level.
Author | : Alfred Wittinghofer |
Publisher | : Springer |
Total Pages | : 299 |
Release | : 2014-09-26 |
Genre | : Science |
ISBN | : 3319077619 |
Download Ras Superfamily Small G Proteins: Biology and Mechanisms 2 Book in PDF, ePub and Kindle
This second of two volumes discusses subfamily proteins which function in molecular and vesicular transport mechanisms inside the cell. In this volume the focus lies on the Rab, Ran and Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 this book provides an comprehensive state-of-the-art work on small G-proteins (GTPases). It is written for Graduates and Professors in Biochemistry and Cell Biology interested in the mechanism and function of small G-proteins but are extremely valuable for those who want to move into the field.
Author | : Manfred Schwab |
Publisher | : Springer Science & Business Media |
Total Pages | : 1017 |
Release | : 2001-10-15 |
Genre | : Medical |
ISBN | : 3540665277 |
Download Encyclopedic Reference of Cancer Book in PDF, ePub and Kindle
This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
Author | : |
Publisher | : Academic Press |
Total Pages | : 364 |
Release | : 2013-09-10 |
Genre | : Science |
ISBN | : 9780124167490 |
Download Inhibitors of the Ras Superfamily G-proteins, Part A Book in PDF, ePub and Kindle
This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field
Author | : |
Publisher | : Elsevier |
Total Pages | : 527 |
Release | : 2001-04-17 |
Genre | : Science |
ISBN | : 0080522556 |
Download Regulators and Effectors of Small GTPases, Part F: Ras Family I Book in PDF, ePub and Kindle
The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today, truly an essential publication for researchers in all fields of life sciences. This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325 and 329) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.
Author | : Richard A. Kahn |
Publisher | : Springer Science & Business Media |
Total Pages | : 368 |
Release | : 2004-02-29 |
Genre | : Science |
ISBN | : 1402017197 |
Download ARF Family GTPases Book in PDF, ePub and Kindle
For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.