Radiolabeled Monoclonal Antibodies PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Radiolabeled Monoclonal Antibodies PDF full book. Access full book title Radiolabeled Monoclonal Antibodies.

Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Radiolabeled Monoclonal Antibodies for Imaging and Therapy
Author: Suresh C. Srivastava
Publisher: Springer Science & Business Media
Total Pages: 851
Release: 2013-03-14
Genre: Medical
ISBN: 1468455389

Download Radiolabeled Monoclonal Antibodies for Imaging and Therapy Book in PDF, ePub and Kindle

The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.


Cancer Imaging with Radiolabeled Antibodies

Cancer Imaging with Radiolabeled Antibodies
Author: David M. Goldenberg
Publisher: Springer Science & Business Media
Total Pages: 469
Release: 2012-12-06
Genre: Medical
ISBN: 1461314976

Download Cancer Imaging with Radiolabeled Antibodies Book in PDF, ePub and Kindle

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.


Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Radiolabeled Monoclonal Antibodies for Imaging and Therapy
Author:
Publisher:
Total Pages:
Release: 1986
Genre:
ISBN:

Download Radiolabeled Monoclonal Antibodies for Imaging and Therapy Book in PDF, ePub and Kindle

This meeting focused on areas of research on radiolabeled monoclonal antibodies. Topics covered included the production, purification, and fragmentation of monoclonal antibodies and immunochemistry of hybridomas; the production and the chemistry of radionuclides; the radiohalogenation and radiometal labeling techniques; the in-vivo pharmacokinetics of radiolabeled antibodies; the considerations of immunoreactivity of radiolabeled preparations; the instrumentation and imaging techniques as applied to radioimmunodetection; the radiation dosimetry in diagnostic and therapeutic use of labeled antibodies; the radioimmunoscintigraphy and radioimmunotherapy studies; and perspectives and directions for future research. Tutorial as well as scientific lectures describing the latest research data on the above topics were presented. Three workshop panels were convened on ''Methods for Determining Immunoreactivity of Radiolabeled Monoclonal Antibodies - Problems and Pitfalls, '' Radiobiological and Dosimetric Considerations for Immunotherapy with Labeled Antibodies, '' and ''The Human Anti-Mouse Antibody Response in Patients.''


Cancer Therapy with Radiolabeled Antibodies

Cancer Therapy with Radiolabeled Antibodies
Author: David M. Goldenberg
Publisher: CRC Press
Total Pages: 405
Release: 2018-01-18
Genre: Law
ISBN: 1351087304

Download Cancer Therapy with Radiolabeled Antibodies Book in PDF, ePub and Kindle

Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.


Systemic Radiotherapy with Monoclonal Antibodies

Systemic Radiotherapy with Monoclonal Antibodies
Author: Marie-Luise Sautter-Bihl
Publisher: Springer Science & Business Media
Total Pages: 200
Release: 2012-12-06
Genre: Medical
ISBN: 3642799523

Download Systemic Radiotherapy with Monoclonal Antibodies Book in PDF, ePub and Kindle

Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.


Production of Radiolabeled Monoclonal Antibody Conjugates by Photoaffinity Labeling

Production of Radiolabeled Monoclonal Antibody Conjugates by Photoaffinity Labeling
Author:
Publisher:
Total Pages: 9
Release: 1990
Genre:
ISBN:

Download Production of Radiolabeled Monoclonal Antibody Conjugates by Photoaffinity Labeling Book in PDF, ePub and Kindle

This report discusses activities and progress that has occurred since initiation of this project on September 1, 1989. We have synthesized ethyl N, N(prime)-bis(benzoylmercaptoacetyl)-2,3-diaminopropanoate, a ligand to be used as a bifunctional chelating agent (BFCA), to form 186Re or 188Re (186Re/188Re) complexes. 186Re/188Re, in reducing media, reacts with this ligand to form 186Re/188Re-CO2DADS chelates that will be used to formulate new radiolabeled photoaffinity labels (RPALs). Initial steps have been taken to synthesize R-As-dithiol compounds. This approach will be used to produce 77As-RPALs or covalently link 77As directly to monoclonal antibodies (MAbs). The R group will contain a group that can be used for conjugation reactions. Spectral and photochemical properties of various types of photoaffinity labels (PALs) have been studied. Acrylo-azido compounds and 9-azido acridine have been studied as well as several other photoprobes. The binding characteristics of the azido-based PALs to HSA have been studied and progress has been made on developing techniques for efficiently separating of non-covalently sound PALs. The Nd-YAG laser was purchased and arrived in 1990. It has been assembled and tested and is now operational.