Radiation and the lymphatic system
Author | : John E. Ballou |
Publisher | : |
Total Pages | : 0 |
Release | : |
Genre | : |
ISBN | : |
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Author | : John E. Ballou |
Publisher | : |
Total Pages | : 0 |
Release | : |
Genre | : |
ISBN | : |
Author | : John E. Ballou |
Publisher | : |
Total Pages | : 268 |
Release | : 1976 |
Genre | : Medical |
ISBN | : |
Author | : John L. Meyer |
Publisher | : S. Karger AG (Switzerland) |
Total Pages | : 262 |
Release | : 1994 |
Genre | : Medical |
ISBN | : |
We are entering a new era of understanding the lymphatic system brought about by important insights from experimental investigations and clinical trials.
Author | : Giampiero Ausili Cefaro |
Publisher | : Springer Science & Business Media |
Total Pages | : 176 |
Release | : 2008-08-26 |
Genre | : Medical |
ISBN | : 3540770445 |
This book will facilitate the understanding of cross-sectional anatomy details and assist radiation oncologists in the difficult task of a detailed delineation of lymph node targets in multiple anatomical locations.
Author | : |
Publisher | : |
Total Pages | : 258 |
Release | : 1976 |
Genre | : |
ISBN | : |
Author | : Leonard Weiss |
Publisher | : |
Total Pages | : 576 |
Release | : 1980 |
Genre | : Medical |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : 53 |
Release | : 2007 |
Genre | : |
ISBN | : |
Lymphedema is a common complication of primary breast cancer therapy. It is a chronic insidiously progressive and potentially devastating condition. Radiation increases patients lymphedema risk as conventional fields encompass functioning lymphatics. Fusion imaging technologies that combine anatomical and physiological data may identify these lymphatics and allow tailoring of radiation fields to minimize radiation exposure while preserving regional tumor control. This study uses SPECT scanning to localize lymphatics critical for arm drainage after surgical removal of axillary lymph nodes. The study has established the feasibility of using SPECT images to identify critical lymph nodes on high resolution CT scans used in radiation simulation. Furthermore the study has demonstrated that this technique allows precise quantification of radiation dosimetry delivered to lymph nodes critical for arm drainage. The study will test the hypothesis that increased arm volume correlates with high levels of radiation dosimetry delivered to critical lymph nodes. The fact that higher doses of radiation and larger radiation ports are associated with an increased incidence of lymphedema (volume up arrow> = 150ml.) particularly severe lymphedema (volume arrow up> = 400ml.) supports this hypothesis. The proposed study realizes the BCRP goals by elucidating a novel means of refining breast cancer treatment to minimize patients risk of developing the most prevalent and dreaded complication of conventional therapy lymphedema.
Author | : S. T. Cantril |
Publisher | : |
Total Pages | : 36 |
Release | : 1947 |
Genre | : Blood platelets |
ISBN | : |
Author | : Giampiero Ausili Cefaro |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2010-10-19 |
Genre | : Medical |
ISBN | : 9783642095764 |
This book will facilitate the understanding of cross-sectional anatomy details and assist radiation oncologists in the difficult task of a detailed delineation of lymph node targets in multiple anatomical locations.
Author | : Katalin Lumniczky |
Publisher | : Frontiers Media SA |
Total Pages | : 283 |
Release | : 2018-05-03 |
Genre | : |
ISBN | : 2889454746 |
For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in the tumor microenvironment, and at systemic level. These observations paved the way for studies exploring optimal combinations of radiotherapy and immunotherapy in order to achieve a synergistic effect to eradicate tumors. However, not all interactions between radiation and the immune system are beneficial, as it was recognized that many of radiation-induced late side effects are also of immune and inflammatory nature. Currently perhaps the most studied field of research in radiation biology is focused around the biological effects of low doses, where many of the observed pathophysiological endpoints are due to mechanisms other than direct radiation-induced cell killing and are immune-related. Finally, it must not be forgotten that the interactions between the ionizing radiations and the immune system are bi-directional, and activation of the immune system also influences the outcome of radiation exposure. This Research Topic brings together 23 articles and aims to give an overview of the complex and very often contradictory nature of the interactions between ionizing radiation and the immune system. Due to its increasing penetrance in the population both through medical diagnostic or environmental sources or during cosmic travel low dose ionizing radiation exposure is becoming a major epidemiological concern world-wide. Several of the articles within the Research Topic specifically address potential long-term health consequences and the underlying mechanisms of low dose radiation exposure. A major intention of the Editors was also to draw the attention of the non-radiobiological scientific community on the fact that ionizing radiation is by far more than purely an immune suppressing agent.