Purinergic System PDF Download
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Author | : Geoffrey Burnstock |
Publisher | : Springer Science & Business Media |
Total Pages | : 724 |
Release | : 2012-06-05 |
Genre | : Medical |
ISBN | : 3642288634 |
Download Purinergic Signalling and the Nervous System Book in PDF, ePub and Kindle
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Author | : Margarete Dulce Bagatini |
Publisher | : Biochemistry |
Total Pages | : 0 |
Release | : 2022-09 |
Genre | : Science |
ISBN | : 9781803557830 |
Download Purinergic System Book in PDF, ePub and Kindle
Characterized as a common signaling pathway between cells, the purinergic system is capable of modulating physiological and biochemical processes. Composed of signaling molecules, regulatory enzymes, and specific receptors, this organization can modulate several basal pathways of the organism. It is understood that purinergic signaling is present in all aspects of immunity and inflammation and studies show that extracellular ATP and its adenosine metabolite are the main mediators of response. These occur since most immune cells express P2 and P1 receptors, which are sensitive to the ATP and adenosine molecules, respectively. This book describes the purinergic system and its correlation with the health and disease process.
Author | : Yong Tang |
Publisher | : Frontiers Media SA |
Total Pages | : 139 |
Release | : 2024-01-26 |
Genre | : Science |
ISBN | : 2832543561 |
Download Purinergic Signalling in the Central Nervous System and its pharmacological importance in neurological and psychiatric illnesses. Book in PDF, ePub and Kindle
This Research Topic aims to honour the 80th birthday of Professor Peter Illes, who is a member of the European Academy of Sciences, the founder/first president of the German Purine Club, and Honorary President of the Chinese Purine Club. He established a worldwide co-operation network on purinergic signalling and is an internationally recognized leader in the field. We aim to collect research articles and reviews from friends, colleagues and co-operation partners of Dr. Illes to showcase, build on and develop research being achieved related to the physiological/pathophysiological roles of purines in the central nervous system (CNS). Adenosine Triphosphate (ATP) is an intracellular energy-storing molecule, but may also reach the extracellular space, where it participates in cell-to-cell signalling. For this purpose, ATP utilises a range of purinergic receptors activated either by ATP itself (P2X receptors; seven subtypes) or by ATP/ADP and UTP/UDP (P2Y receptors; 8 subtypes) and finally via its enzymatic degradation product, adenosine (P1/A receptors; 4 subtypes). Purine nucleotides and nucleosides together with the whole plethora of receptors and degrading enzymes constitute the purinome. This fascinating and extensive network exists both in the animal kingdom and in humans and is essential in regulating important physiological functions. Disturbances in the network can lead to a variety of illnesses clinically associated with both neurological or psychiatric traits. In recent years, hope has arisen that pharmacological chemistry together with various newly developed methods, will enable researchers to discover and design efficient drugs for treating these neurodegenerative and affective diseases.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2001 |
Genre | : Purines |
ISBN | : |
Download Purinergic and Pyrimidinergic Signalling Book in PDF, ePub and Kindle
Author | : Maria P. Abracchio |
Publisher | : Springer Science & Business Media |
Total Pages | : 814 |
Release | : 2001-02-12 |
Genre | : Medical |
ISBN | : 9783540678496 |
Download Purinergic and Pyrimidinergic Signalling Book in PDF, ePub and Kindle
Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Author | : George J. Siegel |
Publisher | : Lippincott Raven |
Total Pages | : 1216 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Download Basic Neurochemistry Book in PDF, ePub and Kindle
Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Author | : Francisco Ciruela |
Publisher | : Frontiers Media SA |
Total Pages | : 852 |
Release | : 2019-08-16 |
Genre | : |
ISBN | : 2889459470 |
Download Purinergic Pharmacology Book in PDF, ePub and Kindle
Author | : Geoffrey Burnstock |
Publisher | : Springer |
Total Pages | : 715 |
Release | : 2012-06-05 |
Genre | : Medical |
ISBN | : 9783642288647 |
Download Purinergic Signalling and the Nervous System Book in PDF, ePub and Kindle
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Author | : Margarete Dulce Bagatini |
Publisher | : |
Total Pages | : 0 |
Release | : 2022 |
Genre | : Cell Biology |
ISBN | : 9781803557847 |
Download Purinergic System Book in PDF, ePub and Kindle
Characterized as a common signaling pathway between cells, the purinergic system is capable of modulating physiological and biochemical processes. Composed of signaling molecules, regulatory enzymes, and specific receptors, this organization can modulate several basal pathways of the organism. It is understood that purinergic signaling is present in all aspects of immunity and inflammation and studies show that extracellular ATP and its adenosine metabolite are the main mediators of response. These occur since most immune cells express P2 and P1 receptors, which are sensitive to the ATP and adenosine molecules, respectively. This book describes the purinergic system and its correlation with the health and disease process.
Author | : Robson Faria |
Publisher | : BoD – Books on Demand |
Total Pages | : 112 |
Release | : 2020-03-11 |
Genre | : Medical |
ISBN | : 1789845343 |
Download Receptors P1 and P2 as Targets for Drug Therapy in Humans Book in PDF, ePub and Kindle
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.