Purinergic Signaling in Health and Disease
| Author | : Eric Boué-Grabot |
| Publisher | : Frontiers Media SA |
| Total Pages | : 330 |
| Release | : 2020-03-13 |
| Genre | : |
| ISBN | : 2889635562 |
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Glutathione System and Oxidative Stress in Health and Disease
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 140 |
| Release | : 2020-08-26 |
| Genre | : Science |
| ISBN | : 1838801251 |
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The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.
Purinergic Signaling
| Author | : Pablo Pelegrín |
| Publisher | : |
| Total Pages | : 360 |
| Release | : 2019 |
| Genre | : Cytology |
| ISBN | : 9781493997176 |
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This volume aims to cover all major methodological aspects of research into purinergic signaling and to provide a foundation for studying them at molecular, biochemical, pharmacological, and physiological levels. Chapters guide readers through current knock-out and knock-in mouse models, in silico modeling, knock down purinoceptor expression, bioluminiscence resonance energy transfer, enzyme-based biosensors, recording P2X receptor electrophysiology, controlling P2X receptors by optogenetics, inflammasome activation, leukocyte migration, and cell adhesion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Purinergic Signaling: Methods and Protocols will provide a sound basis for molecular, cellular, and physiological research into purinergic signaling in health and disease and will spark interest in this fascinating signaling process among researchers in many different and unrelated disciplines.
Purinergic Signaling
| Author | : Pablo Pelegrín |
| Publisher | : |
| Total Pages | : 360 |
| Release | : 2020 |
| Genre | : Cytology |
| ISBN | : 9781493997183 |
Download Purinergic Signaling Book in PDF, ePub and Kindle
This volume aims to cover all major methodological aspects of research into purinergic signaling and to provide a foundation for studying them at molecular, biochemical, pharmacological, and physiological levels. Chapters guide readers through current knock-out and knock-in mouse models, in silico modeling, knock down purinoceptor expression, bioluminiscence resonance energy transfer, enzyme-based biosensors, recording P2X receptor electrophysiology, controlling P2X receptors by optogenetics, inflammasome activation, leukocyte migration, and cell adhesion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Purinergic Signaling: Methods and Protocols will provide a sound basis for molecular, cellular, and physiological research into purinergic signaling in health and disease and will spark interest in this fascinating signaling process among researchers in many different and unrelated disciplines.
Adenosine Triphosphate in Health and Disease
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 86 |
| Release | : 2019-04-24 |
| Genre | : Science |
| ISBN | : 1838802037 |
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This book covers a very important research field; specifically, it tries to decrease the gap between theoretical and clinical research. The tendency of world research is to gain a detailed insight into the living organs of animals and humans. However, we must not lose sight of the problems that these organs can present; for example, we need to understand their molecular and biochemical mechanisms, as well as new drug productions to counteract diseases. Very deep mechanisms can offer new therapeutic pathways in hematology and oncology, among other fields. However, at least 8-l0 years of further clinical studies are necessary to make a final decision regarding the real clinical importance of basic research. Ideally, an interdisciplinary efforts among basic and clinical researchers are necessary in common research fields. At the same time, genetic research is increasing dramatically (e.g. enzyme mutations). The primary aim of this book is to demonstrate how such research can be used in both fields. This book gathers knowledge from experts in basic and clinical science, biochemistry, pharmacology, molecular pharmacology, genetics, and other fields.
Purinergic System
| Author | : Margarete Dulce Bagatini |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2022 |
| Genre | : Cell Biology |
| ISBN | : 9781803557847 |
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Characterized as a common signaling pathway between cells, the purinergic system is capable of modulating physiological and biochemical processes. Composed of signaling molecules, regulatory enzymes, and specific receptors, this organization can modulate several basal pathways of the organism. It is understood that purinergic signaling is present in all aspects of immunity and inflammation and studies show that extracellular ATP and its adenosine metabolite are the main mediators of response. These occur since most immune cells express P2 and P1 receptors, which are sensitive to the ATP and adenosine molecules, respectively. This book describes the purinergic system and its correlation with the health and disease process.
Receptors P1 and P2 as Targets for Drug Therapy in Humans
| Author | : Robson Faria |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 112 |
| Release | : 2020-03-11 |
| Genre | : Medical |
| ISBN | : 1789845343 |
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This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Purinergic Signaling and Inflammation
| Author | : Davide Ferrari |
| Publisher | : Frontiers Media SA |
| Total Pages | : 97 |
| Release | : 2021-07-14 |
| Genre | : Medical |
| ISBN | : 2889710424 |
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Creatine Kinase and Brain Energy Metabolism
| Author | : Téa Kekelidze |
| Publisher | : IOS Press |
| Total Pages | : 204 |
| Release | : 2003 |
| Genre | : |
| ISBN | : 9781586032333 |
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Purinergic Signaling
| Author | : Pablo Pelegrín |
| Publisher | : Humana |
| Total Pages | : 360 |
| Release | : 2020-11-07 |
| Genre | : Science |
| ISBN | : 9781493997190 |
Download Purinergic Signaling Book in PDF, ePub and Kindle
This volume aims to cover all major methodological aspects of research into purinergic signaling and to provide a foundation for studying them at molecular, biochemical, pharmacological, and physiological levels. Chapters guide readers through current knock-out and knock-in mouse models, in silico modeling, knock down purinoceptor expression, bioluminiscence resonance energy transfer, enzyme-based biosensors, recording P2X receptor electrophysiology, controlling P2X receptors by optogenetics, inflammasome activation, leukocyte migration, and cell adhesion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Purinergic Signaling: Methods and Protocols will provide a sound basis for molecular, cellular, and physiological research into purinergic signaling in health and disease and will spark interest in this fascinating signaling process among researchers in many different and unrelated disciplines.
