Purinergic Signaling PDF Download
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Author | : Geoffrey Burnstock |
Publisher | : Springer Science & Business Media |
Total Pages | : 724 |
Release | : 2012-06-05 |
Genre | : Medical |
ISBN | : 3642288634 |
Download Purinergic Signalling and the Nervous System Book in PDF, ePub and Kindle
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
Author | : Rosa Gomez-Villafuertes |
Publisher | : Frontiers Media SA |
Total Pages | : 126 |
Release | : 2020-08-27 |
Genre | : |
ISBN | : 2889639649 |
Download Emerging Mechanisms in Purinergic Signaling: from Cell Biology to Therapeutic Perspectives Book in PDF, ePub and Kindle
Author | : Eric Boué-Grabot |
Publisher | : Frontiers Media SA |
Total Pages | : 330 |
Release | : 2020-03-13 |
Genre | : |
ISBN | : 2889635562 |
Download Purinergic Signaling in Health and Disease Book in PDF, ePub and Kindle
Author | : Davide Ferrari |
Publisher | : Frontiers Media SA |
Total Pages | : 97 |
Release | : 2021-07-14 |
Genre | : Medical |
ISBN | : 2889710424 |
Download Purinergic Signaling and Inflammation Book in PDF, ePub and Kindle
Author | : Francesco Caciagli |
Publisher | : Frontiers Media SA |
Total Pages | : 287 |
Release | : 2021-10-29 |
Genre | : Science |
ISBN | : 2889715701 |
Download Purinergic Signaling 2020: the State-of-The-Art Commented by the Members of the Italian Purine Club Book in PDF, ePub and Kindle
Author | : Pablo Pelegrín |
Publisher | : Humana |
Total Pages | : 360 |
Release | : 2020-11-07 |
Genre | : Science |
ISBN | : 9781493997190 |
Download Purinergic Signaling Book in PDF, ePub and Kindle
This volume aims to cover all major methodological aspects of research into purinergic signaling and to provide a foundation for studying them at molecular, biochemical, pharmacological, and physiological levels. Chapters guide readers through current knock-out and knock-in mouse models, in silico modeling, knock down purinoceptor expression, bioluminiscence resonance energy transfer, enzyme-based biosensors, recording P2X receptor electrophysiology, controlling P2X receptors by optogenetics, inflammasome activation, leukocyte migration, and cell adhesion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Purinergic Signaling: Methods and Protocols will provide a sound basis for molecular, cellular, and physiological research into purinergic signaling in health and disease and will spark interest in this fascinating signaling process among researchers in many different and unrelated disciplines.
Author | : Henning Ulrich |
Publisher | : Springer Nature |
Total Pages | : 381 |
Release | : 2023-07-16 |
Genre | : Medical |
ISBN | : 3031269454 |
Download Purinergic Signaling in Neurodevelopment, Neuroinflammation and Neurodegeneration Book in PDF, ePub and Kindle
This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
Author | : Jonathan Soboloff |
Publisher | : CRC Press |
Total Pages | : 258 |
Release | : 2017-03-27 |
Genre | : Medical |
ISBN | : 149870509X |
Download Signaling Mechanisms Regulating T Cell Diversity and Function Book in PDF, ePub and Kindle
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author | : Robson Faria |
Publisher | : BoD – Books on Demand |
Total Pages | : 112 |
Release | : 2020-03-11 |
Genre | : Medical |
ISBN | : 1789845343 |
Download Receptors P1 and P2 as Targets for Drug Therapy in Humans Book in PDF, ePub and Kindle
This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Author | : Francisco Ciruela |
Publisher | : Frontiers Media SA |
Total Pages | : 852 |
Release | : 2019-08-16 |
Genre | : |
ISBN | : 2889459470 |
Download Purinergic Pharmacology Book in PDF, ePub and Kindle