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Proteins in Solution and at Interfaces

Proteins in Solution and at Interfaces
Author: Juan M. Ruso
Publisher: John Wiley & Sons
Total Pages: 823
Release: 2013-01-31
Genre: Science
ISBN: 1118523172

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Explores new applications emerging from our latest understanding of proteins in solution and at interfaces Proteins in solution and at interfaces increasingly serve as the starting point for exciting new applications, from biomimetic materials to nanoparticle patterning. This book surveys the state of the science in the field, offering investigators a current understanding of the characteristics of proteins in solution and at interfaces as well as the techniques used to study these characteristics. Moreover, the authors explore many of the new and emerging applications that have resulted from the most recent studies. Topics include protein and protein aggregate structure; computational and experimental techniques to study protein structure, aggregation, and adsorption; proteins in non-standard conditions; and applications in biotechnology. Proteins in Solution and at Interfaces is divided into two parts: Part One introduces concepts as well as theoretical and experimental techniques that are used to study protein systems, including X-ray crystallography, nuclear magnetic resonance, small angle scattering, and spectroscopic methods Part Two examines current and emerging applications, including nanomaterials, natural fibrous proteins, and biomolecular thermodynamics The book's twenty-three chapters have been contributed by leading experts in the field. These contributions are based on a thorough review of the latest peer-reviewed findings as well as the authors' own research experience. Chapters begin with a discussion of core concepts and then gradually build in complexity, concluding with a forecast of future developments. Readers will not only gain a current understanding of proteins in solution and at interfaces, but also will discover how theoretical and technical developments in the field can be translated into new applications in material design, genetic engineering, personalized medicine, drug delivery, biosensors, and biotechnology.


Proteins at Liquid Interfaces

Proteins at Liquid Interfaces
Author: D. Möbius
Publisher: Elsevier
Total Pages: 497
Release: 1998-04-24
Genre: Science
ISBN: 9780080540009

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The interfacial behaviour of surfactants and proteins, and their mixtures, is of importance in a wide range of areas such as food technology, detergency, cosmetics, coating processes, biomedicine, pharmacy and biotechnology. Methods such as surface and interfacial tension measurements and interfacial dilation and shear rheology characterise the relationships between these interfacial properties and the complex behaviour of foams and emulsions is established. Recently-developed experimental techniques, such as FRAP which enable the measurement of molecular mobility in adsorption layers, are covered in this volume. The development of theories to describe the thermodynamic surface state or the exchange of matter for proteins and protein/surfactant mixtures is also described. Features of this book: • Reflects the state-of-the-art research and application of protein interfacial layers rather than a snapshot of only some recent developments. • Emphasis is placed on experimental details as well as recent theoretical developments. • New experimental techniques applied to protein interfacial layers are described, such as FRAP or ADSA, or rheological methods to determine the mechanical behaviour of protein-modified interfaces. • A large number of practical applications, ranging from emulsions relevant in food technology for medical problems such as lung surfactants, to the characterisation of foams intrinsic to beer and champagne production. The book will be of interest to research and university institutes dedicated to interfacial studies in chemistry, biology, pharmacy, medicine and food engineering. Industrial departments for research and technology in food industry, pharmacy, medicine and brewery research will also find this volume of value.


Surfactants in Solution

Surfactants in Solution
Author: K.L. Mittal
Publisher: Springer Science & Business Media
Total Pages: 581
Release: 2013-03-09
Genre: Science
ISBN: 1461579813

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This and its companion Volumes 4 and 6 document the proceedings of the 5th International Symposium on Surfactants in Solution held in Bordeaux, France, July 9-13, 1984. This symposium was the continuation of the series of symposia initiated in 1976 in Albany, New York under the title "Micellization, Solubilization and Microemulsions". The next two symposia were labelled "Solution Chemistry of Surfactants" and "Solution Behavior of Surfactants: Theoretical and Applied Aspects" held in Knoxville, TN in 1978 and Potsdam, N. Y. in 1980, respectively. In 1982 at the time of the 4th Symposium in this series, it became amply evident that there was a definite need to have more a generic title to describe these biennial events, and after much deliberation it was decided that an appropriate title would be "Surfactants in Solution" as both the aggregation and adsorption aspects of surfactants were addressed. So the 4th Symposium was held in 1982 in Lund, Sweden, under this new rubric, and it was decided to continue these symposia in the future under this appellation. Naturally, the Bordeaux Symposium was dubbed as the 5th International Symposium on Surfactants in Solution, and our logo became SIS which is very apropos and appealing. It was in Bordeaux that the decision was made to hold the 6th SIS Symposium in New Delhi and it is scheduled for August 18-22, 1986 in the capital of India.


Molecular Biology of The Cell

Molecular Biology of The Cell
Author: Bruce Alberts
Publisher:
Total Pages: 0
Release: 2002
Genre: Cytology
ISBN: 9780815332183

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Protein Conformation

Protein Conformation
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
Total Pages: 282
Release: 2008-04-30
Genre: Science
ISBN: 0470514159

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How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.


ProteinProtein Interaction Regulators

ProteinProtein Interaction Regulators
Author: Siddhartha Roy
Publisher: Royal Society of Chemistry
Total Pages: 399
Release: 2020-12-14
Genre: Science
ISBN: 1839160500

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New genomic information has revealed the crucial role that protein–protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein–Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.


Protein Instability at Interfaces During Drug Product Development

Protein Instability at Interfaces During Drug Product Development
Author: Jinjiang Li
Publisher: Springer Nature
Total Pages: 338
Release: 2021-02-12
Genre: Medical
ISBN: 3030571777

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Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.