Protein Tyrosine Kinases PDF Download
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| Author | : Doriano Fabbro |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 599 |
| Release | : 2007-11-13 |
| Genre | : Science |
| ISBN | : 1592599621 |
Download Protein Tyrosine Kinases Book in PDF, ePub and Kindle
Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.
| Author | : Deric L. Wheeler |
| Publisher | : Springer |
| Total Pages | : 888 |
| Release | : 2015-07-31 |
| Genre | : Science |
| ISBN | : 3319118889 |
Download Receptor Tyrosine Kinases: Family and Subfamilies Book in PDF, ePub and Kindle
This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.
| Author | : Deric L. Wheeler |
| Publisher | : Springer |
| Total Pages | : 452 |
| Release | : 2014-11-26 |
| Genre | : Science |
| ISBN | : 1493920537 |
Download Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease Book in PDF, ePub and Kindle
Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.
| Author | : Joseph Schlessinger |
| Publisher | : |
| Total Pages | : 478 |
| Release | : 2013 |
| Genre | : Science |
| ISBN | : 9781936113330 |
Download Signaling by Receptor Tyrosine Kinases Book in PDF, ePub and Kindle
Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF), and molecules involved in neuronal guidance. Ligand binding stimulates the tyrosine kinase activity of the receptors, leading to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation, differentiation, and numerous other biological processes. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the mechanisms underlying receptor tyrosine kinase signaling, including ligand processing, receptor dimerization, receptor trafficking, and the roles of adapters. The contributors also survey the specific functions of the different subfamilies of receptors and examine their many roles in development and normal physiology. In addition, the authors review the important roles of these proteins in insulin resistance and cancer. This volume is thus a vital reference for cell and developmental biologists as well as those working on cancer biology, diabetes, and obesity.
| Author | : Jeremy Copp |
| Publisher | : |
| Total Pages | : 346 |
| Release | : 2003 |
| Genre | : |
| ISBN | : |
Download Normal and Pathological Activation of Receptor Protein-tyrosine Kinases Book in PDF, ePub and Kindle
| Author | : Grahame Hardie |
| Publisher | : Academic Press |
| Total Pages | : 260 |
| Release | : 1995-06-19 |
| Genre | : Medical |
| ISBN | : |
Download The Protein Kinase Factsbook, Two-Volume Set Book in PDF, ePub and Kindle
Volume 1: How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 65 entries on members of the family from vertebrates, Drosophila, slime moulds and other organisms. Entries provide information on: * Subunit structure and isoforms * Genetics * Sequence database accession numbers * Domain structures * Amino acid sequences * Homologues in other species * Patterns of expression * Physiological substrates and specificity determinants * Assays * Enzyme activators and inhibitors * References Volume 2: How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 130 entries on members of the family from vertebrates, Drosophila, higher plants, yeasts, nematodes, slime moulds and other organisms. Entries provide information on: * Subunit structure and isoforms * Genetics * Sequence database accession numbers * Domain structures * Amino acid sequences * Homologues in other species * Patterns of expression * Physiological substrates and specificity determinants * Assays * Enzyme activators and inhibitors * References
| Author | : Girdhar K. Pandey |
| Publisher | : John Wiley & Sons |
| Total Pages | : 560 |
| Release | : 2020-12-03 |
| Genre | : Science |
| ISBN | : 1119541565 |
Download Protein Kinases and Stress Signaling in Plants Book in PDF, ePub and Kindle
A comprehensive review of stress signaling in plants using genomics and functional genomic approaches Improving agricultural production and meeting the needs of a rapidly growing global population requires crop systems capable of overcoming environmental stresses. Understanding the role of different signaling components in plant stress regulation is vital to developing crops which can withstand abiotic and biotic stresses without loss of crop yield and productivity. Emphasizing genomics and functional genomic approaches, Protein Kinases and Stress Signaling in Plants is a comprehensive review of cutting-edge research on stress perception, signal transduction, and stress response generation. Detailed chapters cover a broad range of topics central to improving agricultural production developing crop systems capable of overcoming environmental stresses to meet the needs of a rapidly growing global population. This book describes the field of protein kinases and stress signaling with a special emphasis on functional genomics. It presents a highly valuable contribution in the field of stress perception, signal transduction and generation of responses against one or multiple stress signals. This timely resource: Summarizes the role of various kinases involved in stress management Enumerates the role of TOR, GSK3-like kinase, SnRK kinases in different physiological conditions Examines mitogen-activated protein kinases (MAPKs) in different stresses Describes the different aspects of calcium signaling under different stress conditions Examines photo-activated kinases (PAPKs) in varying light conditions Briefs the presence of tyrosine kinases in plants Highlights the cellular functions of receptor ]like protein kinases (RLKs) Possible implication of these kinases in developing stress tolerant crops Protein Kinases and Stress Signaling in Plants: Functional Genomic Perspective is an essential resource for researchers and students in the fields of plant molecular biology and signal transduction, plant responses to stress, plant cell signaling, plant protein kinases, plant biotechnology, transgenic plants and stress biology.
| Author | : |
| Publisher | : ScholarlyEditions |
| Total Pages | : 192 |
| Release | : 2012-01-09 |
| Genre | : Medical |
| ISBN | : 1464925151 |
Download Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition Book in PDF, ePub and Kindle
Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein-Tyrosine Kinases. The editors have built Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein-Tyrosine Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
| Author | : |
| Publisher | : ScholarlyEditions |
| Total Pages | : 138 |
| Release | : 2012-12-26 |
| Genre | : Medical |
| ISBN | : 1481601253 |
Download Protein-Tyrosine Kinases—Advances in Research and Application: 2012 Edition Book in PDF, ePub and Kindle
Protein-Tyrosine Kinases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Protein-Tyrosine Kinases. The editors have built Protein-Tyrosine Kinases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein-Tyrosine Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protein-Tyrosine Kinases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
| Author | : |
| Publisher | : ScholarlyEditions |
| Total Pages | : 205 |
| Release | : 2012-01-09 |
| Genre | : Medical |
| ISBN | : 1464924872 |
Download Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition Book in PDF, ePub and Kindle
Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Receptor Protein-Tyrosine Kinases. The editors have built Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Receptor Protein-Tyrosine Kinases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Receptor Protein-Tyrosine Kinases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
