Protein Surface Recognition PDF Download
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Author | : Ernest Giralt |
Publisher | : John Wiley & Sons |
Total Pages | : 296 |
Release | : 2011-07-07 |
Genre | : Science |
ISBN | : 1119957214 |
Download Protein Surface Recognition Book in PDF, ePub and Kindle
A new perspective on the design of molecular therapeutics is emerging. This new strategy emphasizes the rational complementation of functionality along extended patches of a protein surface with the aim of inhibiting protein/protein interactions. The successful development of compounds able to inhibit these interactions offers a unique chance to selectively intervene in a large number of key cellular processes related to human disease. Protein Surface Recognition presents a detailed treatment of this strategy, with topics including: an extended survey of protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective the fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces examples of protein surface-small molecule interactions, including treatments of protein-natural product interactions, protein-interface peptides, and rational approaches to protein surface recognition from model to biological systems a survey of techniques that will be integral to the discovery of new small molecule protein surface binders, from high throughput synthesis and screening techniques to in silico and in vitro methods for the discovery of novel protein ligands. Protein Surface Recognition provides an intellectual “tool-kit” for investigators in medicinal and bioorganic chemistry looking to exploit this emerging paradigm in drug discovery.
Author | : Wei Sun |
Publisher | : |
Total Pages | : 0 |
Release | : 2009 |
Genre | : |
ISBN | : |
Download Protein Surface Recognition by Polymers Book in PDF, ePub and Kindle
Author | : Lun Kelvin Tsou |
Publisher | : |
Total Pages | : 440 |
Release | : 2007 |
Genre | : |
ISBN | : |
Download Protein Surface Recognition by Functional Synthetic Macrocyclic Receptors for Modulation of Protein-protein Interactions Book in PDF, ePub and Kindle
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Download Molecular Biology of The Cell Book in PDF, ePub and Kindle
Author | : James Muldoon |
Publisher | : |
Total Pages | : 0 |
Release | : 2009 |
Genre | : |
ISBN | : |
Download Protein Surface Recognition by Designed Metal Complexes Book in PDF, ePub and Kindle
Author | : Rishi K. Jain |
Publisher | : |
Total Pages | : 404 |
Release | : 2002 |
Genre | : |
ISBN | : |
Download Protein Surface Recognition by Synthetic Receptors Based on Macrocylic Scaffolds Book in PDF, ePub and Kindle
Author | : Xavier Salvatella i Giralt |
Publisher | : |
Total Pages | : 144 |
Release | : 2002 |
Genre | : |
ISBN | : |
Download Peptide and protein surface recognition by tetraguanidinium compounds Book in PDF, ePub and Kindle
Author | : Colin Kleanthous |
Publisher | : Frontiers in Molecular Biology |
Total Pages | : 370 |
Release | : 2000 |
Genre | : Carrier proteins |
ISBN | : 9780199637607 |
Download Protein-protein Recognition Book in PDF, ePub and Kindle
The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.
Author | : Julian Mintseris |
Publisher | : |
Total Pages | : 242 |
Release | : 2006 |
Genre | : |
ISBN | : |
Download Structure-driven Approaches to Protein-protein Recognition Book in PDF, ePub and Kindle
Abstract: Much of our understanding of protein function arises from the cellular context in which the protein operates. While two proteins may be functionally linked in a variety of ways, the most direct way for them to interact is through physical recognition of the protein surface followed by a binding event. If the function of a single protein can be understood in terms of its interactions, then the function of a biological system as a whole can be viewed through the network of protein interactions. I use structure-driven approaches to gain additional insight into the organization of protein interaction networks by showing distinct differences between transient and obligate protein interactions. This important distinction can be detected on a purely structural level by comparing the pair-wise contact frequencies between different types of atoms at the protein complex interface. On the functional level, the distinction can be made by looking at the curated ontology annotations. Proteins involved in transient and obligate interactions have been subject to different levels of evolutionary pressure and traces of these differences can be detected by considering their evolutionary histories. Residues in the interfaces of obligate complexes tend to evolve at a relatively slower rate, allowing them to co-evolve with their interacting partners. In contrast, the plasticity inherent in transient interactions leads to an increased rate of substitution for the interface residues and leaves little or no evidence of correlated mutations. Recent advances in high-throughput proteomic technologies combined with computational approaches have identified large numbers of putative novel interactions. However both experimental and computational approaches tend to do better identifying components of large obligate complexes, while fleeting interactions crucial in systems such as signaling cascades and immune response are harder to predict. To this end, I developed new representations of protein structure and derived empirical potentials for protein-protein docking, improving on our ability to predict the complex structures of transient complexes from individually crystallized components.
Author | : Mehdi Khodaei |
Publisher | : |
Total Pages | : 132 |
Release | : 2020-07 |
Genre | : |
ISBN | : 1838805974 |
Download Superhydrophobic Surfaces Book in PDF, ePub and Kindle