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Author | : Gerhard Zbinden |
Publisher | : Springer-Verlag |
Total Pages | : 124 |
Release | : 2013-03-07 |
Genre | : Science |
ISBN | : 3642662927 |
Download Progress in Toxicology Book in PDF, ePub and Kindle
THE STATE OF THE ART The recent seventies have not been good times for toxicologists. Public confidence in us is shaken, mostly as a consequence of an unhappy sequence of spectacular failures: we have been surprised by a tragic transplacental carcinogenic effect of diethylstilbestrol, an old and widely prescribed synthetic estrogen. We are confronted with a small epidemic of an unusual liver tumor, angiosarcoma, induced by a simple chemical, vinylchloride, whose insiduous toxic potential we failed to "recognize for years. Our clinical colleagues had to tell us about the ulcerogenic effect of as simple a substance as potassium chloride. We also just learned of an unusual toxic reaction, pseudolupus, developing in people taking a popular fixed-combination drug, venocuran~ Admit tedly, we could not have predicted this syndrome, even if we had con sidered the possibility. We are still unable (to continue this self-flagellation) to explain the relationship between the appetite suppressant arninorex and the sud denly increased occurrence of a lung disease posing as primary pulmonary hypertension. And worse yet, we have no way to evaluate a new deriva tive of this class, and to predict whether or not it, too, will produce the deadly condition. We still, to my knowledge, have no plausible ex planation why and how thalidomide caused phocomelia. Of course, we do diligently a set of teratological experiments with each new drug; we follow a protocol which has the blessing of all governmental regulatory agencies.
Author | : Gerhard Zbinden |
Publisher | : Springer |
Total Pages | : 104 |
Release | : 1973 |
Genre | : Medical |
ISBN | : |
Download Progress in Toxicology: Special Topics Book in PDF, ePub and Kindle
Author | : Gerhard Zbinden |
Publisher | : |
Total Pages | : |
Release | : 1973 |
Genre | : |
ISBN | : |
Download Progress in toxicology Book in PDF, ePub and Kindle
Author | : Gerhard Zbinden |
Publisher | : Springer-Verlag |
Total Pages | : 93 |
Release | : 2013-03-07 |
Genre | : Science |
ISBN | : 3642930220 |
Download Progress in Toxicology Book in PDF, ePub and Kindle
SPECIAL TOPICS I was then Director of Biological Research of a pharmaceutical company just west of the Hackensack River swamps when my collabora tors presented me with an impressive book. Its gold-embossed title read: "WHAT I KNOW ABOUT BIOLOGICAL RESEARCH by GERHARD ZBINDEN, M.D. ". Those acquainted with the subtleties of American humor will have guessed the book's content: about 700 empty pages. But I liked the idea enough to write down what I knew about my branch of biologi Ical research, drug toxicology. With gentle prodding by Dr. Parkhurst IShore of Dallas, Texas, I assembled a review on those experimental and clinical aspects of drug toxicology with which I, as an industrial toxicologist, had been most concerned with. It turned out to be a modest paper, considerably less than 700 pages, but it seemed to fill a need for others who were laboring on similar problems (Zbinden 1963). Drug toxicology has changed much since 1963 when the review ap peared. Its problems have certainly not become smaller. Scientists of many biological specialties have become interested in questions of harmful drug effects. Their input has greatly enriched the knowledge of the basic processes underlying certain forms of toxic drug reac tions. With this surge of interest and effort, extreme specialization has occurred which sometimes tended to dominate the toxicological scene.
Author | : Gerhard Zbinden |
Publisher | : |
Total Pages | : |
Release | : 1973 |
Genre | : |
ISBN | : |
Download Progress in Toxicology Book in PDF, ePub and Kindle
Author | : G. Zbinden |
Publisher | : |
Total Pages | : |
Release | : 1976 |
Genre | : |
ISBN | : |
Download Progress in Toxicology; Special Topics Book in PDF, ePub and Kindle
Author | : Abraham Stolman |
Publisher | : Elsevier |
Total Pages | : 449 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483219224 |
Download Progress in Chemical Toxicology Book in PDF, ePub and Kindle
Progress in Chemical Toxicology, Volume 1 covers the developments in toxicology, including the usefulness of the developed techniques and methods with necessary modifications for toxicological studies. The book describes the isolation and separation techniques for the identification of poisons; the application of gas chromatograph to toxicology; and the pharmacological and toxicological effects aliphatic alcohols. The text also discusses the isolation, purification, identication, and the toxicology of acidic and neutral poisons, ataraxics and nonbarbiturate sedatives. The determination of antiarthritics, antihistamines, and thymoleptics; the physicochemical properties for the identification of narcotics and related bases; and the toxicity of air pollutants are also considered. The book further tackles the analytical methods for air pollutants; the occurrence, symptoms, and treatment of mushroom poisoning; and the toxic components of poisonous seeds and fruits poisonous seeds and fruits. Toxicologists, chemists, and scientists in forensic science laboratories will find the text invaluable.
Author | : Abraham Stolman |
Publisher | : Elsevier |
Total Pages | : 431 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483224910 |
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Progress in Chemical Toxicology, Volume 3 explores the developments in methods and instrumentation for toxicological analyses. This book is composed of eight chapters, and begins with a description of the pharmacologic and physiologic effects of aliphatic alcohols. The succeeding chapter deals with the methods of analysis of various volatile poisons, such as halogenated aliphatic compounds, aromatic hydrocarbons, and acid compounds. A chapter focuses on the methods of determination and classic procedures for carbon monoxide analysis in breath and blood. These topics are followed by discussions on the development of spectrochemical methods chemical and radiochemical methods of determination of radionuclides in human bones and tissues; and the toxic effects of combined drug action. The last chapter examines the poison residue occurrence in human tissues. This book is of great value to toxicologists and public health workers and researchers.
Author | : Society of Toxicology (India). Conference |
Publisher | : |
Total Pages | : 440 |
Release | : 1988 |
Genre | : Environmental health |
ISBN | : |
Download Advances in Toxicology and Environmental Health Book in PDF, ePub and Kindle
Author | : National Library of Medicine (U.S.) |
Publisher | : |
Total Pages | : 1584 |
Release | : 1984 |
Genre | : Medicine |
ISBN | : |
Download Index of NLM Serial Titles Book in PDF, ePub and Kindle
A keyword listing of serial titles currently received by the National Library of Medicine.