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Author | : A. D. Kinghorn |
Publisher | : Springer |
Total Pages | : 258 |
Release | : 2014-08-11 |
Genre | : Science |
ISBN | : 3319049003 |
Download Progress in the Chemistry of Organic Natural Products 99 Book in PDF, ePub and Kindle
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author | : A. Douglas Kinghorn |
Publisher | : |
Total Pages | : 260 |
Release | : 2014-08-31 |
Genre | : |
ISBN | : 9783319049014 |
Download Progress in the Chemistry of Organic Natural Products 99 Book in PDF, ePub and Kindle
Author | : A. Douglas Kinghorn |
Publisher | : Springer Nature |
Total Pages | : 271 |
Release | : 2019-10-16 |
Genre | : Science |
ISBN | : 3030146324 |
Download Progress in the Chemistry of Organic Natural Products 110 Book in PDF, ePub and Kindle
The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
Author | : A. D. Kinghorn |
Publisher | : |
Total Pages | : 258 |
Release | : 2014 |
Genre | : Biochemistry |
ISBN | : 9788875487065 |
Download Progress in the Chemistry of Organic Natural Products 99 Book in PDF, ePub and Kindle
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author | : A. D. Kinghorn |
Publisher | : Springer |
Total Pages | : 602 |
Release | : 2014-11-17 |
Genre | : Science |
ISBN | : 3319052756 |
Download Progress in the Chemistry of Organic Natural Products 100 Book in PDF, ePub and Kindle
The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author | : A. Douglas Kinghorn |
Publisher | : Springer Nature |
Total Pages | : 239 |
Release | : |
Genre | : |
ISBN | : 303159567X |
Download Progress in the Chemistry of Organic Natural Products 124 Book in PDF, ePub and Kindle
Author | : P. R. Ashurst |
Publisher | : Springer Science & Business Media |
Total Pages | : 362 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 370918164X |
Download Progress in the Chemistry of Organic Natural Products / Fortschritte der Chemie Organischer Naturstoffe / Progrès dans la Chimie des Substances Organiques Naturelles Book in PDF, ePub and Kindle
Mit Beiträgen zahlreicher Fachwissenschaftler
Author | : A. Douglas Kinghorn |
Publisher | : Springer Science & Business Media |
Total Pages | : 269 |
Release | : 2011-08-12 |
Genre | : Science |
ISBN | : 3709107482 |
Download Progress in the Chemistry of Organic Natural Products Vol. 94 Book in PDF, ePub and Kindle
The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.
Author | : A. Douglas Kinghorn |
Publisher | : Springer Nature |
Total Pages | : 212 |
Release | : 2020-12-11 |
Genre | : Science |
ISBN | : 3030529665 |
Download Progress in the Chemistry of Organic Natural Products 112 Book in PDF, ePub and Kindle
The first chapter describes the oldest method of communication between living systems in Nature, the chemical language. Plants, due to their lack of mobility, have developed the most sophisticated way of chemical communication. Despite that many examples involve this chemical communication process - allelopathy, there is still a lack of information about specific allelochemicals released into the environment, their purpose, as well as in-depth studies on the chemistry underground. These findings are critical to gain a better understanding of the role of these compounds and open up a wide range of possibilities and applications, especially in agriculture and phytomedicine. The most relevant aspects regarding the chemical language of plants, namely, kind of allelochemicals have been investigated, as well as their releasing mechanisms and their purpose, are described in this chapter. The second chapter is focused on the natural products obtained from Hypericum L., a genus of the family Hypericaceae within the dicotyledones. Hypericum has been valued for its important biological and chemical properties and its use in the treatment of depression and as an antibacterial has been well documented in primary literature and ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents and biological effects of this genus. A comprehensive account of the chemical constituents including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects. The third chapter addresses microtubule stabilizers, which are a mainstay in the treatment of many solid cancers and are often used in combination with molecularly targeted anticancer agents and immunotherapeutics. The taccalonolides are a unique class of such microtubule stabilizers isolated from plants of Tacca species that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule stabilizing activity of the taccalonolides is independent of direct tubulin binding, additional studies have found that potent C-22,23 epoxidated taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule stabilizing activity. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction and the opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.
Author | : A. Douglas Kinghorn |
Publisher | : Springer Nature |
Total Pages | : 265 |
Release | : 2021-10-26 |
Genre | : Science |
ISBN | : 3030805603 |
Download Progress in the Chemistry of Organic Natural Products 116 Book in PDF, ePub and Kindle
This volume describes several highly diverse subjects: Chapter 1 explores marine biodiscovery of the North-eastern Atlantic off the coast of Ireland as a model for best practice in research. The second chapter investigates Brazilian Chemical Ecology and examples of insect-plant communication studies that are mediated by natural products demonstrate the beautiful interconnectedness of species in a biome. Our third chapter comprises the advances in the science of the sesquiterpene quinone, perezone, which in 1852 was the first natural product isolated in crystalline form in the New World. The last two chapters are from a Vietnamese group and the first of these follows the phytochemistry, pharmacology, and ethnomedical uses of the genus Xanthium, which produces interesting sulfur and nitrogen containing natural products. Finally, the genus Desmos is discussed, where an overview of its constituent natural products and their in vitro pharmacological potential is described.