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Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology
Author: Moiz Mumtaz
Publisher: John Wiley & Sons
Total Pages: 625
Release: 2011-05-23
Genre: Science
ISBN: 3527632115

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This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in industry or healthcare institutions with little time for academic study.


Human Toxicology of Chemical Mixtures

Human Toxicology of Chemical Mixtures
Author: Harold Zeliger
Publisher: William Andrew
Total Pages: 575
Release: 2011-06-24
Genre: Medical
ISBN: 1437734642

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In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author’s focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body’s methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations – far too many to comprehensively catalog) A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures


Toxicology of Chemical Mixtures

Toxicology of Chemical Mixtures
Author: Raymond S.H. Yang
Publisher: Elsevier
Total Pages: 745
Release: 2013-10-22
Genre: Science
ISBN: 1483289400

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Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure. Some of the issues addressed include Target organ toxicities in response to chemical mixture exposures Risk assessment and experimental approaches Case studies and special pollution problems Special pollution problems


Principles of Toxicology

Principles of Toxicology
Author: Phillip L. Williams
Publisher: John Wiley & Sons
Total Pages: 625
Release: 2003-10-10
Genre: Science
ISBN: 0471459232

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A fully updated and expanded edition of the bestselling guide on toxicology and its practical application The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features: Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems Coverage of occupational medicine and epidemiological issues The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins Special emphasis on the evaluation and control of toxic hazards Specific case histories on applying risk assessment methods in the modern workplace Ample figures, references, and a comprehensive glossary of toxicological terms


Mixture Toxicity

Mixture Toxicity
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
Total Pages: 312
Release: 2016-04-19
Genre: Medical
ISBN: 1439830096

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In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an


Human Toxicology of Chemical Mixtures

Human Toxicology of Chemical Mixtures
Author: Harold Zeliger
Publisher: William Andrew
Total Pages: 627
Release: 2008-07-25
Genre: Technology & Engineering
ISBN: 0815519842

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This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals. Addresses chemical mixtures, while most literature only deals with single chemicals exposure Explains why certain toxicological effects are observed Discusses diagnosis and treatment of injuries resulting from exposure Explores consequences of effects on product formulation, use, handling and required warnings Provides guidelines for safer development of personal care, cosmetic, industrial and consumer use products


Toxicology

Toxicology
Author: M A SUBRAMANIAN
Publisher: MJP Publisher
Total Pages: 350
Release: 2019-06-06
Genre: Medical
ISBN:

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The study of toxicants—their route of entry, theirabsorption, distribution, elimination and transformation,and their dynamics within organisms and theenvironment—have been clearly dealt with in this book. Itprovides a concise, well-balanced and technicalintroduction to toxicology with focus on the basic principlesand concepts. It would prove to be a complete study unit fornew entrants to this field. The chapter “Impact of pollutantson aquatic organisms” has been written exclusively basedon the author’s laboratory observations.


Toxicological Risk Assessment of Chemicals

Toxicological Risk Assessment of Chemicals
Author: Elsa Nielsen
Publisher: CRC Press
Total Pages: 450
Release: 2008-02-21
Genre: Medical
ISBN: 1420006940

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Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk


The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors

The Toxicology of Chemical Mixtures Risk Assessment for Human and Ecological Receptors
Author:
Publisher:
Total Pages: 101
Release: 2005
Genre:
ISBN:

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Mixtures of chemicals represent a concern in all areas of toxicology and a challenge to risk assessors as most sites with environmental contamination, including Department of Defense sites, involve simultaneous or sequential exposures of multiple chemicals to human or ecological receptors. A major concern with mixtures is that they may lead to outcomes (health effects) or increased toxicity (synergism) not expected from the risk characterization of individual chemicals at the site. The focus of this literature review is 0 examine the principles used to determine toxicity in chemical mixtures risk assessment for human and ecological receptors at hazardous waste sites. This review provides an overview of current practices useful to a remedial project manager or risk assessor prior to their first chemical mixtures risk assessment.


Principles of Toxicology

Principles of Toxicology
Author: Stephen M. Roberts
Publisher: John Wiley & Sons
Total Pages: 496
Release: 2014-12-08
Genre: Science
ISBN: 1118982517

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A fully updated and expanded edition of the bestselling guide on toxicology and its practical application • Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards • New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology • Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems • Includes case histories and examples from industry demonstrate the application of toxicological principles • Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms