Prevention And Control Of Human T Lymphotropic Viruses 1 And 2 Htlv 1 2 PDF Download

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Human T-lymphotropic virus type 1

Human T-lymphotropic virus type 1
Author:
Publisher: World Health Organization
Total Pages: 78
Release: 2021-02-19
Genre: Medical
ISBN: 9240020225

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Human T‐cell lymphotropic virus‐1 (HTLV‐1), is a retrovirus which causes lifelong infection in humans. Infection is sometimes asymptomatic, but chronic infection causes a spectrum of various clinical syndromes, the severe ones being an aggressive malignancy known as adult T-cell leukaemia/lymphoma (ATL) and a progressive neurological condition known as HTLV-1-associated myelopathy. This Technical report on HTLV-1 captures the epidemiological status and management approaches for HTLV-1 virus infection and the diseases it causes. It presents best practice approaches and research evidence on how countries have addressed HTLV-1 so far. Prior to this report the WHO undertook consultations with member states and partners. Few public health measures have been implemented on a global scale to prevent infection with HTLV-1 or its consequences, or to manage ATL and HAM/TSP. Current evidence from countries suggests that more concerted global public health actions in containing this infectious disease can be implemented via integrated approach in the existing country programmes of STIs and HIV prevention and control. These include ongoing monitoring and surveillance of the virus. Blood testing at transfusion clinics, cessation of breast feeding, and partner testing and condom promotion are useful prevention strategies. Testing and treatment methods need new innovations with better technology to improve performance and efficacy. This report is a tool towards improving HTLV-1 prevention and control and reducing morbidity and mortality due to the virus.


Viral and Immunological Malignancies

Viral and Immunological Malignancies
Author: Paul Volberding
Publisher: PMPH-USA
Total Pages: 440
Release: 2006
Genre: AIDS (Disease)
ISBN: 9781550092561

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The precise relationship between viral infection and malignancy remains an epidemiologic association and the subject of active investigation. Nonmalignant hematologic disorders have a similarly complex relationship with cancer-associated viruses and may offer insight into the pathogenesis of oncogenesis. This book explores the relationships between viral infections, immune impairments and the hematologic and malignant diseases, particularly against the backdrop of the HIV epidemic. By extending the scope to all of viral oncology the editors provide an invaluable resource on tumors related to other viruses other than HIV, particularly carcinomas of the cervix and anus with HPV and tumors of the liver with the various hepatitis viruses.


Screening Donated Blood for Transfusion-transmissible Infections

Screening Donated Blood for Transfusion-transmissible Infections
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 73
Release: 2010
Genre: Medical
ISBN: 924154788X

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"Blood transfusion is a life-saving intervention that has an essential role in patient management within health care systems. All Member States of the World Health Organization (WHO) endorsed World Health Assembly resolutions WHA28.72 (1) in 1975 and WHA58.13 (2) in 2005. These commit them to the provision of adequate supplies of safe blood and blood products that are accessible to all patients who require transfusion either to save their lives or promote their continuing or improving health." --Preface.


Pathology and Pathogenesis of Human Viral Disease

Pathology and Pathogenesis of Human Viral Disease
Author: John E. Craighead
Publisher: Academic Press
Total Pages: 466
Release: 2000-03-15
Genre: Medical
ISBN: 0080538487

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Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection. Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians. Provides a comprehensive, worldwide perspective of viral disease pathology Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology Addresses topics from the perspective of the clinical pathologist Illustrates unique, viral induced pathological lesions Considers common and uncommon complications of infection


Human Retroviruses

Human Retroviruses
Author: Bryan Cullen
Publisher: Oxford University Press
Total Pages: 220
Release: 1993
Genre: Gene Expression Regulation.
ISBN: 9780199633821

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The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.


Human Retroviruses

Human Retroviruses
Author: Elisa Vicenzi
Publisher: Humana
Total Pages: 0
Release: 2016-08-23
Genre: Medical
ISBN: 9781493962587

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Human Retroviruses: Methods and Protocols collects key experimental protocols that have provided the basis of the major discoveries of the field. Split into five sections, this detailed volume covers mapping of the HIV life cycle, isolation, co-receptor use, and cell tropism of HIV-1, in vivo quantification of HIV-1, biological aspects of HIV-1, as well as HTLVs. Some articles explore “assay and function of accessory genes”, largely involving the interface between retroviral and host factors, the extracellular role of Tat and Tax, resembling the function of cytokines, and the biotechnological exploitation of HIV as lentiviral vector to carry foreign genes with therapeutic value. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Human Retroviruses: Methods and Protocols provides state-of-art methodological protocols from world leaders in human retrovirology, essential for any lab working this vital field.


Cytokine Storm Syndrome

Cytokine Storm Syndrome
Author: Randy Q. Cron
Publisher: Springer Nature
Total Pages: 607
Release: 2019-09-09
Genre: Medical
ISBN: 303022094X

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Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.


Persistent Viral Infections

Persistent Viral Infections
Author: R. Ahmed
Publisher: Wiley-Blackwell
Total Pages: 754
Release: 1999
Genre: Medical
ISBN:

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Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.


Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation
Author: Hillard M. Lazarus
Publisher: Springer Science & Business Media
Total Pages: 885
Release: 2010-03-02
Genre: Medical
ISBN: 1597454788

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Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.