Precision Molecular Pathology Of Breast Cancer PDF Download
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| Author | : Ashraf Khan |
| Publisher | : Springer |
| Total Pages | : 336 |
| Release | : 2015-08-12 |
| Genre | : Medical |
| ISBN | : 1493928864 |
Download Precision Molecular Pathology of Breast Cancer Book in PDF, ePub and Kindle
This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.
| Author | : Sunil Badve |
| Publisher | : Springer |
| Total Pages | : 427 |
| Release | : 2016-11-26 |
| Genre | : Medical |
| ISBN | : 3319417614 |
Download Molecular Pathology of Breast Cancer Book in PDF, ePub and Kindle
The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.
| Author | : Mehmet Gunduz |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 236 |
| Release | : 2015-03-25 |
| Genre | : Medical |
| ISBN | : 9535120301 |
Download A Concise Review of Molecular Pathology of Breast Cancer Book in PDF, ePub and Kindle
Cancer is one of the leading causes of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed gene expression and DNA abnormalities including methylation in breast cancer. A recent important topic, roles of miRNAs and their potential use in cancer therapy have been discussed in this cancer type as well. Bioinformatics is very important part of recent human genome developments and data mining and thus this topic has also been added for the readers. It is hoped that this book will contribute to development of novel diagnostic as well as therapeutic approaches, which lead to cure of breast cancer.
| Author | : Stuart J. Schnitt |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 276 |
| Release | : 2012-10-02 |
| Genre | : Medical |
| ISBN | : 1455739421 |
Download Breast Pathology: Diagnosis and Insights, An Issue of Surgical Pathology Clinics Book in PDF, ePub and Kindle
Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular lesions of the breast; Combined epithelial-myoepithelial lesion; Immunhistochemical pitfalls in the diagnosis of breast lesions; Pathology considerations in patients treated with neoadjuvant chemotherapy; Molecular classification of breast cancer: Jorge Reis-Filho; Prognostic factors for patients with breast cancer: Traditional and New
| Author | : Michael T. Deavers |
| Publisher | : Springer |
| Total Pages | : 286 |
| Release | : 2017-10-28 |
| Genre | : Medical |
| ISBN | : 3319579851 |
Download Precision Molecular Pathology of Uterine Cancer Book in PDF, ePub and Kindle
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
| Author | : Brian D. Robinson |
| Publisher | : Springer |
| Total Pages | : 570 |
| Release | : 2018-02-13 |
| Genre | : Medical |
| ISBN | : 3319640968 |
Download Precision Molecular Pathology of Prostate Cancer Book in PDF, ePub and Kindle
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
| Author | : Alexandra Louise Hubbard |
| Publisher | : |
| Total Pages | : |
| Release | : 1996 |
| Genre | : |
| ISBN | : |
Download Some Aspects of the Molecular Pathology of Breast Cancer Book in PDF, ePub and Kindle
| Author | : Yi Ding |
| Publisher | : Springer Nature |
| Total Pages | : 449 |
| Release | : 2021-07-10 |
| Genre | : Medical |
| ISBN | : 3030732274 |
Download Practical Oncologic Molecular Pathology Book in PDF, ePub and Kindle
This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.
| Author | : Donna E. Hansel |
| Publisher | : Springer |
| Total Pages | : 243 |
| Release | : 2018-01-05 |
| Genre | : Medical |
| ISBN | : 3319647695 |
Download Precision Molecular Pathology of Bladder Cancer Book in PDF, ePub and Kindle
This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.
| Author | : |
| Publisher | : |
| Total Pages | : 268 |
| Release | : 2002 |
| Genre | : |
| ISBN | : |
Download Resources for Precision Analysis of Human Breast Cancer Book in PDF, ePub and Kindle
The past decade has seen dramatic progress in our understanding of the basic cell and molecular biology of breast cancer. However, the translation of this basic science knowledge and ideas has been impeded by the limited numbers of clinician-scientists with skills to effectively collaborate with basic scientists and to accurately interpret tissue pathology, quality and the cellular composition of heterogeneous tissue samples subjected to molecular study. Beyond this there is the problem of access to appropriate human tissue samples. The Pi's overall goal is the improvement in our current ability to predict individual risk of development of invasive disease and to predict further progression of invasive disease in terms of resistance to therapies. The specific aims of the PI are (1) continue to advance the two general avenues of research that are currently ongoing in the laboratory and which have direct relevance to important clinical problems in the management of early pre-invasive disease and the therapy of later advanced disease, (2) continue to direct the Manitoba Breast Tumor Bank and offer clinical pathology expertise and advice to many investigators who seek access to appropriate tissues to test their ideas, and (3) to work with others to develop and analyze new tissue resources such as those based on collection of pre-invasive lesions and tissue samples and collection of tumor samples associated with clinical trials.
