Point Of Care And High Density Array Electrochemical Biosensors PDF Download
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Author | : Alexander Chuan Sun |
Publisher | : |
Total Pages | : 119 |
Release | : 2018 |
Genre | : |
ISBN | : |
Download Point-of-Care and High-Density Array Electrochemical Biosensors Book in PDF, ePub and Kindle
As a result of numerous advances towards miniaturization in several diverse fields including chemistry, nanofabrication, microfluidics, and electronics, point-of-care (PoC) biosensors have become a promising tool to combat the most life-threatening and expensive health issues affecting the world today. PoC technology helps solve these problems by allowing for diagnostic tools typically restricted to centralized facilities to be brought closer to the point of diagnosis for faster and more frequent testing in both clinical and remote settings. While many biosensor types exist, electrochemical-based detection has the advantage that it is inherently compatible with circuits, requiring only electrodes for transduction, allowing it fully to benefit from both Moore's Law scaling and the well-established semiconductor manufacturing industry to produce miniaturized, cost-effective, and portable devices. However, there has been a lack of successful PoC electrochemical platforms capable of running multiple diagnostic tests or multi-analyte assays due to the difficultly of balancing power and area constraints of the circuitry with maintaining the required sensitivity. Therefore, in this dissertation, the circuit and system design of two electrochemical biosensor platforms are presented that explore the challenges of implementing both multi-technique and multi-analyte biosensors at the PoC. The first is a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone technologies to enable personal health monitoring. By repurposing components from one mode to the next, the biosensor is able to efficiently reconfigure itself into three different measurement modes allowing it to run a variety of assays. Each distinct mode is able to match the performance of state-of-the-art single technique biosensors, while all being integrated onto a single device at a fraction of the size. The 3.9x1.65 cm2 module was used with a modular smartphone for a variety of real-world point-of-care applications. Scaling the sensors further for high-density multi-analyte testing, a 4,096-pixel electrochemical biosensor array in 180 nm CMOS is presented. It uses a coulostatic discharge sensing technique and interdigitated electrode (IDE) geometry design to reduce the size of the readout circuitry. Each biopixel contains an IDE with a 13 aA low-leakage readout circuit directly underneath. Compared to standard electrodes, the implemented IDEs along with their inherent 3-D trenches achieve an amplification factor of 10.5x from redox cycling. The array's sensor density is comparable to state-of-the-art arrays, all without augmenting the sensors with complex post-processing. The simultaneous detection of anti-Rubella and anti-Mumps antibodies in human serum is demonstrated.
Author | : Serge Cosnier |
Publisher | : CRC Press |
Total Pages | : 405 |
Release | : 2015-01-26 |
Genre | : Science |
ISBN | : 9814411477 |
Download Electrochemical Biosensors Book in PDF, ePub and Kindle
Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
Author | : Sushma Dave |
Publisher | : John Wiley & Sons |
Total Pages | : 309 |
Release | : 2023-06-26 |
Genre | : Science |
ISBN | : 3527350454 |
Download Point-of-Care Biosensors for Infectious Diseases Book in PDF, ePub and Kindle
Point-of-Care Biosensors for Infectious Diseases Comprehensive resource covering key developments in biosensor-based diagnostics for infectious diseases With its overview of currently available technologies, Point-of-Care Biosensors for Infectious Diseases serves as a starting point for the successful development and application of pathogen biosensors in a point-of-care setting. Here, expert authors review current challenges in pathogen detection and the selection of suitable biomarkers, detail currently available biosensor platforms including electrochemical, piezoelectric, magnetic, and optical sensors, and cover technology development for point-of-care biosensors for viral, bacterial, and parasitic infections. Point-of-Care Biosensors for Infectious Diseases covers key topics such as: Fundamentals of biosensor detection, with a focus on optical and electrochemical techniques Organic and inorganic based nanomaterials for healthcare diagnostics Strategies for miniaturizing biosensor devices, and state-of-the-art integrated sensing platforms Latest trends in point-of-care biosensing systems to detect, diagnose, and monitor infectious diseases Providing comprehensive coverage of the subject, Point-of-Care Biosensors for Infectious Diseases is an excellent reference for all developers, researchers, and technology managers in the areas of molecular diagnosis, infectious diseases, biosensors, and related fields.
Author | : Gorachand Dutta |
Publisher | : Springer Nature |
Total Pages | : 252 |
Release | : 2022-12-02 |
Genre | : Science |
ISBN | : 9811971307 |
Download Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics Book in PDF, ePub and Kindle
This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare.
Author | : JuKyung Lee |
Publisher | : |
Total Pages | : 147 |
Release | : 2016 |
Genre | : Antigens |
ISBN | : |
Download Hypersensitive Electrochemical Biosensors Based on Nanowell Array Structures for Point of Care Technology Book in PDF, ePub and Kindle
Biomarkers are sensitive indicators of pathogenic processes and pharmaceutical responses. Most of these biomarkers are present in the body with extremely low concentration and should be accurately and continually monitored to evaluate the dynamic physiological responses upon exposure to pathogens or drugs. However, conventional assays such as Enzyme linked immuno-sorbent assay (ELISA) and mass spectrometry can only take static and one time measurements, the process is long, expensive, and requires specialist equipment. Therefore, there is need for an advanced sensing system that is cost-effective, portable, and capable of simultaneously detecting very low levels of specific biomarkers with stable and reusable point of care technology (POCT). The goal of this thesis is to develop hyper sensitive biosensors based on electrochemical detection to recognize analytes a using nanowell array (NWA) electrode technology. NWA electrodes have been shown to enable faster detection of biomolecules with reproducibility much better than other approaches. In this thesis, I used fabricated a NWA on a 6-inch Si wafer by krypton-fluoride (KrF) stepper semiconductor process in order to develop NWA sensor through a combination of low cost and high throughput nano-pattern. Finally 57 uniform and homogeneous NWA electrodes were obtained on a 6-inch wafer. Second, to validate this NWA as a biosensor, several biomarkers were detected and monitored. In this part, first, NWA as immunosensor, antibody was immobilized on the NWA, and alkaline phosphatase (ALP) for bone monitoring and stress induced protein 1 (STIP-1) as ovarian cancer monitoring were used as antigen. Specific current and impedance were measured to quantify these analytes binding to the electrode. The Limit of detection (LOD) and the sensitivity & selectivity is highly increased compared with conventional micro-sized electrodes with reducing non-specific binding. Finally, these results suggest that wafer-scale NWA biosensor is useful for sensing application field for point of care technology because their structure provides for an advantage for detecting molecular binding events.
Author | : Fan Xia |
Publisher | : Springer Nature |
Total Pages | : 269 |
Release | : 2023-10-02 |
Genre | : Technology & Engineering |
ISBN | : 9819956447 |
Download Electrochemical Biosensors for Whole Blood Analysis Book in PDF, ePub and Kindle
This book illustrates recent advances in developing sensitive and selective electrochemical biosensors for their whole blood application. Known to be a cutting-edge and fast-growing technology, electrochemical biosensors demonstrate their potential in laboratories, industries, and healthcare to achieve specific and direct target detection in complex media, and have become an emerging technology for guiding personalized medicine. The book first demonstrates methods and models to cover the detection of a variety of target molecules in whole blood, including ions, small molecules, nucleic acids, proteins, cells, etc. Then, it provides comments on various detection strategies employed to improve sensors' sensitivity, specificity, selectivity, and reproducibility as well as presenting the laws and principles. In addition, it summarizes achievements and challenges from recent years. Finally, it provides future perspectives and opportunities in electrochemical biosensors including point of care detection, molecular diagnostics and the integration of this sensor platform with multidisciplinary technologies, towards the ultimate goal of personalized medicine. The book integrates abundant viewpoints from multiple sciences and is helpful and valuable to a wide readership in the various fields of biochemistry, biophysics, bioengineering, and pharmaceutics.
Author | : Roger Narayan |
Publisher | : Woodhead Publishing |
Total Pages | : 318 |
Release | : 2016-08-21 |
Genre | : Medical |
ISBN | : 0081000782 |
Download Medical Biosensors for Point of Care (POC) Applications Book in PDF, ePub and Kindle
Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications Includes contributions from leading international researchers with extensive experience in developing medical biosensors Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care
Author | : Xueji Zhang |
Publisher | : Academic Press |
Total Pages | : 625 |
Release | : 2011-04-28 |
Genre | : Science |
ISBN | : 008055489X |
Download Electrochemical Sensors, Biosensors and their Biomedical Applications Book in PDF, ePub and Kindle
This book broadly reviews the modem techniques and significant applications of chemical sensors and biosensors. Chapters are written by experts in the field – including Professor Joseph Wang, the most cited scientist in the world and renowned expert on sensor science who is also co-editor. Each chapter provides technical details beyond the level found in typical journal articles, and explores the application of chemical sensors and biosensors to a significant problem in biomedical science, also providing a prospectus for the future.This book compiles the expert knowledge of many specialists in the construction and use of chemical sensors and biosensors including nitric oxide sensors, glucose sensors, DNA sensors, hydrogen sulfide sensors, oxygen sensors, superoxide sensors, immuno sensors, lab on chip, implatable microsensors, et al. Emphasis is laid on practical problems, ranging from chemical application to biomedical monitoring and from in vitro to in vivo, from single cell to animal to human measurement. This provides the unique opportunity of exchanging and combining the expertise of otherwise apparently unrelated disciplines of chemistry, biological engineering, and electronic engineering, medical, physiological. Provides user-oriented guidelines for the proper choice and application of new chemical sensors and biosensors Details new methodological advancements related to and correlated with the measurement of interested species in biomedical samples Contains many case studies to illustrate the range of application and importance of the chemical sensors and biosensors
Author | : Zvi Liron |
Publisher | : Springer Science & Business Media |
Total Pages | : 322 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 146151231X |
Download Novel Approaches in Biosensors and Rapid Diagnostic Assays Book in PDF, ePub and Kindle
In the medical, food, and environmental fields there is a continuous demand for inexpensive and sensitive analytical devices that are reliable, rapid, capable of high-throughput screening, and have low cost per test unit. Small and portable biosensor devices are designed to fulfill most of these requirements, and can be used in laboratory and on-site field testing. This volume discusses major issues in optical, acoustic and electrochemical-based biosensors, biochips, sensing recognition elements, and biosensors for medical and environmental applications. The papers presented at the conference represent basic and applied research studies in the fields of diagnostic assays and biosensor development. Novel technologies, such as arrays of sensors using high-density fiber optics to sense labeled or unlabeled oligonucleotides, and patterned arrays of recognition elements, demonstrated the capability of biosensors to analyze multiple analytes.
Author | : Vijay Singh Rathore |
Publisher | : Springer Nature |
Total Pages | : 473 |
Release | : |
Genre | : |
ISBN | : 9819739918 |
Download Emerging Trends in Expert Applications and Security Book in PDF, ePub and Kindle