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PNH and the GPI-Linked Proteins

PNH and the GPI-Linked Proteins
Author: Neal S. Young
Publisher: Elsevier
Total Pages: 279
Release: 2000-04-28
Genre: Medical
ISBN: 9780080492094

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Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mechanism of hemolysis, the biochemistry of glycosylphosphoinositol anchors, and the chemistry and biophysics of GPI-anchored proteins. This unique and timely volume will have a wide audience, including hematologists and oncologists with a clinical interest in this disease, as well as basic biochemists, immunologists, and cell biologists studying this class of proteins. Outlines the chemical features of PNH Explains the mechanism of hemolysis Includes work on the biochemistry of glycophosphoinositol anchors Contains descriptions of the chemistry and biophysics of GPI-anchored proteins


Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria
Author: Yuzuru Kanakura
Publisher: Springer
Total Pages: 358
Release: 2017-01-16
Genre: Medical
ISBN: 4431560033

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This volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. Although the PIGA gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. This book, Paroxysmal Nocturnal Hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. It serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting GPI-anchored proteins and complements, and hematologists specializing in bone marrow failure.


Congenital and Acquired Bone Marrow Failure

Congenital and Acquired Bone Marrow Failure
Author: Mahmoud Deeb Aljurf
Publisher: Elsevier
Total Pages: 274
Release: 2016-12-23
Genre: Science
ISBN: 0128041757

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Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine. Provides an overview of all congenital and acquired bone marrow failure syndromes Focuses on the molecular pathogenesis, clinical manifestation and diagnosis, laboratory features, and treatment of each disease within the syndromes Features the area of supportive care which is a topic of great interest to infectious disease physicians and those involved in transfusion services


Paroxysmal Nocturnal Hemoglobinuria and Related Disorders

Paroxysmal Nocturnal Hemoglobinuria and Related Disorders
Author: M. Omine
Publisher: Springer Science & Business Media
Total Pages: 376
Release: 2012-12-06
Genre: Medical
ISBN: 4431678670

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Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.


Clinical Cytometry

Clinical Cytometry
Author: Michael Andreeff
Publisher:
Total Pages: 424
Release: 1986
Genre: Science
ISBN:

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Aplastic Anemia

Aplastic Anemia
Author: Hubert Schrezenmeier
Publisher: Cambridge University Press
Total Pages: 410
Release: 2000
Genre: Medical
ISBN: 9780521641012

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Comprehensive and up-to-date clinical reference, with an emphasis on treatment.


Diagnosis of Blood and Bone Marrow Disorders

Diagnosis of Blood and Bone Marrow Disorders
Author: Sa A. Wang
Publisher: Springer
Total Pages: 412
Release: 2018-06-04
Genre: Medical
ISBN: 3319202790

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This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasms for all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.


Human Blood Groups

Human Blood Groups
Author: Geoff Daniels
Publisher: John Wiley & Sons
Total Pages: 950
Release: 2013-01-16
Genre: Medical
ISBN: 1118493540

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Human Blood Groups is a comprehensive and fully referenced text covering both the scientific and clinical aspects of red cell surface antigens, including: serology, inheritance, biochemistry, molecular genetics, biological functions and clinical significance in transfusion medicine. Since the last edition, seven new blood group systems and over 60 new blood group antigens have been identified. All of the genes representing those systems have now been cloned and sequenced. This essential new information has made the launch of a third edition of Human Blood Groups, now in four colour, particularly timely. This book continues to be an essential reference source for all those who require clinical information on blood groups and antibodies in transfusion medicine and blood banking.


The Saint-Chopra Guide to Inpatient Medicine

The Saint-Chopra Guide to Inpatient Medicine
Author: Sanjay Saint
Publisher: Oxford University Press, USA
Total Pages: 609
Release: 2018
Genre: Medical
ISBN: 0190862807

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Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.


Benign Hematologic Disorders in Children

Benign Hematologic Disorders in Children
Author: Deepak M. Kamat
Publisher: Springer Nature
Total Pages: 512
Release: 2020-08-18
Genre: Medical
ISBN: 3030499804

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This book provides a comprehensive overview of benign hematologic disorders in children. Divided into nine sections, the text reviews common hematologic disorders or conditions that affect children, while providing state-of-the-art information on pathophysiology, diagnosis, treatment, and management strategies. The text begins with a section on hematopoiesis, and the next section covers red blood cell disorders. The following sections provide overviews of platelet disorders, white blood cell disorders, and coagulation disorders. The sixth and seventh sections discuss neonatal hematology and bone marrow failure syndrome. The eighth section reviews supportive care, while the final section covers miscellaneous subjects including pediatric vascular anomalies and complement dysregulation syndromes. Written by experts in the field, Benign Hematologic Disorders in Children: A Clinical Guide is a valuable resource for clinicians and practitioners who treat children afflicted with these disorders.