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Plant-Derived Anticancer Drugs in the OMICS Era

Plant-Derived Anticancer Drugs in the OMICS Era
Author: Deepu Pandita
Publisher: CRC Press
Total Pages: 323
Release: 2023-10-27
Genre: Science
ISBN: 1000852172

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The current anti-cancer synthetic medicines are deemed inefficient and unsafe, state the editors of this new book. Plant-based lead molecules, however, such as taxol, camptothecin, podophyllotoxins, vinblastine, vincristine, homoharringtonine, and numerous other anticancer compounds from nature’s arsenal, are potentially safe and can be powerful alternatives that effectively fight against cancer. The volume looks at a variety of medicinal plants and approaches that have shown beneficial results against cancer. Topics in the book include Unani approaches of anticancer plants, genetic engineering and CRISPR/CAS-mediated editing to enhance a plant’s anticancer potential, computational approaches used in anticancer plants, and more. The volume also examines the metabolomics of plants that give them anti-cancer properties.


Plant-derived Anticancer Drugs in the Omics Era

Plant-derived Anticancer Drugs in the Omics Era
Author: Deepu Pandita
Publisher:
Total Pages: 0
Release: 2023
Genre:
ISBN: 9781774912669

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"The current anti-cancer synthetic medicines are inefficient and unsafe. The plants-based lead molecules such as taxol, camptothecin, podophyllotoxins, vinblastine, vincristine, homoharringtonine and numerous other anticancer compounds from Nature's arsenal are potentially safe and powerful alternative means that effectively fight against cancer. The volume looks at a variety of medicinal plants and approaches that have beneficial results against cancer. Topics include Unani approaches of anticancer plants, genetic engineering and CRISPR/CAS-mediated editing to enhance anticancer potential, computational approaches used in anticancer plants, and more. The volume also examines the metabolomics of plants that give them anti-cancer properties. This volume, Plant-Derived Anticancer Drugs in the OMICS Era: Biosynthesis, Function, and Applications, will be valuable to cancer researchers and drug developers among others"--


Cancer Genetics and Therapeutics

Cancer Genetics and Therapeutics
Author: Madhumita Roy
Publisher: Springer Nature
Total Pages: 227
Release: 2019-09-16
Genre: Medical
ISBN: 9811394717

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The book discusses cancer and the potential use of phytochemicals as cancer therapeutics. It begins with the basics of cancer, including the definition, types, etiology and molecular mechanisms involved, before discussing the fundamentals of diagnosis, treatment and associated problems as well as remedial measures. Since cancer is not a single disease, and the mechanisms of carcinogenesis are different for different cancers, it examines the genes and proteins involved in carcinogenesis, and signal transduction pathways for each individual cancer type. Further, the book reviews the latest research on phytochemicals for cancer treatment, highlighting their anti-cancer properties, sources, structure, active biomolecules and probable mechanisms of action, and describing their biochemical properties in the context of cancer prevention and treatment.


Industrial Crop Plants

Industrial Crop Plants
Author: Nitish Kumar
Publisher: Springer Nature
Total Pages: 423
Release:
Genre:
ISBN: 9819710030

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Functional Foods in Cancer Prevention and Therapy

Functional Foods in Cancer Prevention and Therapy
Author: Yearul Kabir
Publisher: Academic Press
Total Pages: 522
Release: 2020-04-07
Genre: Health & Fitness
ISBN: 0128161515

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Functional Foods in Cancer Prevention and Therapy presents the wide range of functional foods associated with the prevention and treatment of cancer. In recent decades, researchers have made progress in our understanding of the association between functional food and cancer, especially as it relates to cancer treatment and prevention. Specifically, substantial evidence from epidemiological, clinical and laboratory studies show that various food components may alter cancer risk, the prognosis after cancer onset, and the quality of life after cancer treatment. The book documents the therapeutic roles of well-known functional foods and explains their role in cancer therapy. The book presents complex cancer patterns and evidence of the effective ways to control cancers with the use of functional foods. This book will serve as informative reference for researchers focused on the role of food in cancer prevention and physicians and clinicians involved in cancer treatment. Discusses the role of functional foods in cancer therapy Presents research-based evidence of the role of herbs and bioactive foods in cancer treatment and prevention Provides the most current, concise, scientific information regarding the efficacy of functional foods in preventing cancer and improving the quality of life Explores antioxidants, phytochemicals, nutraceuticals, herbal medicine and supplements in relation to cancer prevention and treatment Contains a clinical approach to the use of functional foods to prevent and treat cancer Emphasizes the role and mechanism of functional foods, including the characterization of active compounds on cancer prevention and treatment


Antidiabetic Potential of Plants in the Era of Omics

Antidiabetic Potential of Plants in the Era of Omics
Author: Deepu Pandita
Publisher: CRC Press
Total Pages: 443
Release: 2022-12-30
Genre: Medical
ISBN: 1000574997

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Here is an informative overview of diabetes mellitus in conjunction with plant-based treatments. It discusses available methods for studying the antidiabetic activities of scientifically developed plant products, mechanisms of action, their therapeutic superiority, and current genome editing research perspectives and biotechnological approaches. The book begins with an introduction to diabetes, giving a brief overview of the history, diagnosis, classification, pathophysiology, and risk factors. It goes on to review traditional uses of plants for diabetes along with ethnobotanical information. The results of scientific studies on the various modes of action of antidiabetic plants are discussed, such as the molecular aspects of active plantbased antidiabetic drug molecules. A section featuring recent biotechnological advancements of antidiabetic plants and plant-based antidiabetic drugs covers advances in molecular breeding and application of molecular markers, biotechnologically engineered transgenic medicinal plants, and advances in genomic editing tools and techniques.


Plant-derived Natural Products

Plant-derived Natural Products
Author: Anne E. Osbourn
Publisher: Springer Science & Business Media
Total Pages: 588
Release: 2009-07-07
Genre: Science
ISBN: 0387854983

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Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.


Ethnopharmacology of Medicinal Plants

Ethnopharmacology of Medicinal Plants
Author: Christophe Wiart
Publisher: Springer Science & Business Media
Total Pages: 236
Release: 2007-11-04
Genre: Medical
ISBN: 1597451606

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In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.


Industrial Biotechnology

Industrial Biotechnology
Author: Christoph Wittmann
Publisher: John Wiley & Sons
Total Pages: 642
Release: 2017-03-06
Genre: Science
ISBN: 3527341811

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The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.


Biotechnology and Production of Anti-Cancer Compounds

Biotechnology and Production of Anti-Cancer Compounds
Author: Sonia Malik
Publisher: Springer
Total Pages: 334
Release: 2017-04-21
Genre: Science
ISBN: 3319538802

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This book discusses cancers and the resurgence of public interest in plant-based and herbal drugs. It also describes ways of obtaining anti-cancer drugs from plants and improving their production using biotechnological techniques. It presents methods such as cell culture, shoot and root culture, hairy root culture, purification of plant raw materials, genetic engineering, optimization of culture conditions as well as metabolic engineering with examples of successes like taxol, shikonin, ingenol mebutate and podophylotoxin. In addition, it describes the applications and limitations of large-scale production of anti-cancer compounds using biotechnological means. Lastly, it discusses future economical and eco-friendly strategies for obtaining anti-cancer compounds using biotechnology.