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Placebos and Nocebos in Headaches

Placebos and Nocebos in Headaches
Author: Dimos D. Mitsikostas
Publisher: Springer
Total Pages: 142
Release: 2019-02-11
Genre: Medical
ISBN: 303002976X

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This book discusses the role of placebos and nocebos in the treatment of headache disorders. These disorders are usually treatable, but safety and tolerability issues mean that available preventive treatments have often limited success, even in the right hands – one in five patients treated with a migraine preventive pharmaceutical agent discontinues treatment for those reasons. The nocebo effect plays a role here, with patients’ negative expectation and previous unpleasant treatment experiences creating negative belief in the treatment’s benefits and safety, which in turn limits treatment outcomes and adherence significantly. In RCTs on migraine prevention, one in 20 patients treated with a placebo discontinued treatment because of adverse events, indicating a considerable nocebo effect; the fewer potential adverse events described in the consent form, the smaller the nocebo effect. As such, physicians treating headache sufferers should acknowledge nocebo as a significant cofactor for treatment adherence and failure, and plan techniques to limit the effects, such as patient education and close follow-up. This highly informative and painstakingly presented book provides scientific insights for professionals and scholars with an interest in internal medicine, neurology and pain medicine.


Placebos and Nocebos in Headaches

Placebos and Nocebos in Headaches
Author: Dimos D. Mitsikostas
Publisher:
Total Pages: 142
Release: 2019
Genre: Electronic books
ISBN: 9783030029777

Download Placebos and Nocebos in Headaches Book in PDF, ePub and Kindle

This book discusses the role of placebos and nocebos in the treatment of headache disorders. These disorders are usually treatable, but safety and tolerability issues mean that available preventive treatments have often limited success, even in the right hands – one in five patients treated with a migraine preventive pharmaceutical agent discontinues treatment for those reasons. The nocebo effect plays a role here, with patients’ negative expectation and previous unpleasant treatment experiences creating negative belief in the treatment’s benefits and safety, which in turn limits treatment outcomes and adherence significantly. In RCTs on migraine prevention, one in 20 patients treated with a placebo discontinued treatment because of adverse events, indicating a considerable nocebo effect; the fewer potential adverse events described in the consent form, the smaller the nocebo effect. As such, physicians treating headache sufferers should acknowledge nocebo as a significant cofactor for treatment adherence and failure, and plan techniques to limit the effects, such as patient education and close follow-up. This highly informative and painstakingly presented book provides scientific insights for professionals and scholars with an interest in internal medicine, neurology and pain medicine. .


Placebo and Pain

Placebo and Pain
Author: Luana Colloca
Publisher: Academic Press
Total Pages: 321
Release: 2013-08-28
Genre: Medical
ISBN: 0123979315

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The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain:“This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues. --Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School Contains historical aspects of the placebo effect Discusses biological and psychological mechanisms of placebo analgesic responses Reviews implications of the placebo effect for clinical research and pain management Includes methodological and ethical aspects of the placebo effect


Talking Cures and Placebo Effects

Talking Cures and Placebo Effects
Author: David A. Jopling
Publisher: Oxford University Press, USA
Total Pages: 333
Release: 2008-05-29
Genre: Medical
ISBN: 0199239509

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Psychodynamic psychotherapy and psychoanalysis have had to defend themselves from a barrage of criticisms throughout their history. In this book David Jopling argues that the changes achieved through therapy are really just functions of placebos that rally the mind's native healing powers. It is a bold new work that delivers yet another blow to Freud and his followers.


The Patient's Brain

The Patient's Brain
Author: Fabrizio Benedetti
Publisher: Oxford University Press
Total Pages: 303
Release: 2011
Genre: Medical
ISBN: 0199579512

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Due to advances within neuroscience, we are now in a much better position to be able to describe and discuss the biological mechanisms that underlie the doctor-patient relationship. Using this knowlege, this book describes and demonstrates the power that the doctor's behaviour has on a patient's behaviour and capacity for recovery from illness.


Essentials of Clinical Research

Essentials of Clinical Research
Author: Stephen P. Glasser
Publisher: Springer
Total Pages: 462
Release: 2014-06-02
Genre: Medical
ISBN: 3319054708

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In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.


Suggestible You

Suggestible You
Author: Erik Vance
Publisher: National Geographic Books
Total Pages: 290
Release: 2016
Genre: Medical
ISBN: 1426217897

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National Geographic's riveting narrative explores the world of placebos, hypnosis, false memories, and neurology to reveal the groundbreaking science of our suggestible minds. Could the secrets to personal health lie within our own brains? Journalist Erik Vance explores the surprising ways our expectations and beliefs influence our bodily responses to pain, disease, and everyday events. Drawing on centuries of research and interviews with leading experts in the field, Vance takes us on a fascinating adventure from Harvard's research labs to a witch doctor's office in Catemaco, Mexico, to an alternative medicine school near Beijing (often called "China's Hogwarts"). Vance's firsthand dispatches will change the way you think--and feel. Expectations, beliefs, and self-deception can actively change our bodies and minds. Vance builds a case for our "internal pharmacy"--the very real chemical reactions our brains produce when we think we are experiencing pain or healing, actual or perceived. Supporting this idea is centuries of placebo research in a range of forms, from sugar pills to shock waves; studies of alternative medicine techniques heralded and condemned in different parts of the world (think crystals and chakras); and most recently, major advances in brain mapping technology. Thanks to this technology, we're learning how we might leverage our suggestibility (or lack thereof) for personalized medicine, and Vance brings us to the front lines of such study.


Placebo Effects: The Meaning of Care in Medicine

Placebo Effects: The Meaning of Care in Medicine
Author: Pekka Louhiala
Publisher: Springer Nature
Total Pages: 141
Release: 2020-03-24
Genre: Philosophy
ISBN: 3030273296

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This book provides a perspective on the concepts placebo and placebo effects, which has been missing so far: a detailed analysis of the history of the terms, their current use, suggested alternatives and the implications of the conceptual confusion. Everybody knows something about placebos and placebo effects. If, however, people are asked to define the concepts, the spectrum becomes wide. Does 'placebo' refer to an inert treatment or does it cover all elements of the patient-physician-interaction except for pharmacological or other physiological mechanisms? Furthermore, if, by definition, a placebo has no effect, what sense does it make to talk about a 'placebo effect'? Even in scientific literature the concepts ‘placebo’ and ‘placebo effect’ are used in many senses and often in a confusing way. While this book discusses many issues which keep puzzling physicians, it also covers the historical developments of the concepts of placebo and placebo effect as well as the conceptual confusion in the definitions. This book is intended for physicians, philosophers, psychologists and any other people interested in placebos, placebo effects and the physician-patient relationship.


How Expectancies Shape Experience

How Expectancies Shape Experience
Author: Irving Kirsch
Publisher: Amer Psychological Assn
Total Pages: 431
Release: 1999-01-01
Genre: Psychology
ISBN: 9781557985866

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In this volume the editor brings together prominent scientists who have studied response expectancies--people's beliefs about their own emotional and physical reactions--in human function and dysfunction over the past decade and leading practitioners who have applied these findings to enhance the effectiveness of pharmacological and psychological treatments. In this book, they extend the understanding of how response expectancies account for symptom maintenance, motivation, and change in such diverse areas as asthma, substance abuse, sexual dysfunction, and smoking; they explain both positive and negative mood states and coping. Their surprising findings point to expectancy modification as a key to enhancing effectiveness of treatment and prevention across settings and theoretical orientations. (PsycINFO Database Record (c) 2004 APA, all rights reserved).


Pharmacological Management of Headaches

Pharmacological Management of Headaches
Author: Dimos D. Mitsikostas
Publisher: Springer
Total Pages: 253
Release: 2015-08-26
Genre: Medical
ISBN: 3319199110

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In this book, headache experts summarize all the currently available therapies for primary headaches and most importantly, describe the ‘tricks’ that can ensure the success of headache pharmacotherapy. Prevention and acute treatment of migraine and cluster headache receive particular attention and individual chapters are devoted to the treatment of primary headaches in special groups, i.e. children, pregnant women and the elderly. Further chapters focus on selected secondary headache disorders and cranial neuralgias for which pharmacotherapy is available. The book is designed to meet the daily practice needs of general physicians, general neurologists, neurologists in training and medical students. Headache remains a leading reason for people to seek medical consultation, and migraine and other primary headache disorders are classified by the WHO as among the most disabling medical conditions in the general population, often affecting individuals during their most productive years. Unfortunately, under treatment and mismanagement are the fate of many headache patients and this book provides a sound basis for optimizing treatment.